B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity

American Association for the Advancement of Science (AAAS) - Tập 336 Số 6085 - Trang 1178-1181 - 2012
Ashraf M. Khalil1, John C. Cambier2, Mark J. Shlomchik3,1
1Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
2Integrated Department of Immunology, National Jewish Health and University of Colorado Health Sciences Center, Denver, CO 80206, USA.
3Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA

Tóm tắt

So Selective The key elements for long-lived antibody-mediated immunity—memory B cells and plasmablasts—are generated in germinal centers, where B cells expressing high-affinity antigen receptors are selected for survival and proliferation in a process called affinity maturation. Unexpectedly, Khalil et al. (p. 1178 , published online 3 May; see the Perspective by Bannard and Cyster ) found that, in contrast to naïve B cells and B cells outside the germinal center, proximal signaling events are impaired downstream of the antigen receptor in mouse germinal center B cells.

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American Association for the Advancement of Science (AAAS)

Tập 336 Số 6085

1178-1181

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