Long-Term Habituation of a Defensive Withdrawal Reflex in <i>Aplysia</i>

American Association for the Advancement of Science (AAAS) - Tập 175 Số 4020 - Trang 451-454 - 1972
Thomas Carew1, Harold M. Pinsker1, Eric R. Kandel1
1Departments of Physiology and Psychiatry, New York University School of Medicine, and Department of Neurobiology and Behavior, Public Health Research Institute of the City of New York, New York 10016

Tóm tắt

A tactile stimulus to the siphon of Aplysia produces a defensive withdrawal reflex consisting of contraction of the siphon, the gill, and the mantle shelf. We studied long-term habituation of this reflex using two types of preparations, one focusing on the siphon component and the other on the gill component of the reflex. Siphon withdrawal, studied in unrestrained animals, showed marked habituation within a single ten-trial training session. Five daily training sessions produced habituaton that built up across days and lasted for at least 3 weeks. Furthermore, spaced training produced significantly longer lasting habituation than massed training. Gill withdrawal, studied in a restrained animal, also showed long-term retention of habituation. Since the neural circuitry of gill withdrawal is relatively well understood, it may be possible to study the cellular mechanisms underlying a long-term behavioral modification.

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Tài liệu tham khảo

10.3109/00207457109146995

10.1126/science.167.3926.1745

KANDEL, E.R., ANNU REV PHYSIOL 32: 193 (1970).

KANDEL, E.R., CELLULAR NEUROPHYSIOLOGICAL APPROACHES IN STUDY OF LEARNING, PHYSIOLOGICAL REVIEWS 48: 65 (1968).

KUPFERMANN, I, COMMUNICATIONS IN BEHAVIORAL BIOLOGY: PART A 2: 13 (1968).

10.1126/science.164.3881.847

10.1126/science.167.3926.1743

LICKEY, M.E., LEARNED BEHAVIOR IN APLYSIA VACCARIA, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 66: 712 (1968).

10.1126/science.167.3926.1740

WOODWORTH, R.S., EXPT PSYCHOL: 786 (1964).

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 175 Số 4020

451-454

Thông tin tác giả