Early postoperative evaluation of pylorus-preserving gastrectomy for gastric cancer

World Journal of Surgery - Tập 19 - Trang 456-460 - 1995
Masashi Kodama, Kenji Koyama1, Teisao Chida1, Akira Arakawa1, Gennady Tur1
1Department of Surgery, Akita University School of Medicine, Akita, Japan

Tóm tắt

Early postoperative evaluation was prospectively performed in 35 gastric cancer patients after pylorus-preserving gastrectomy (PPG) between 1989 and 1991, comparing the results with those of 29 patients who underwent conventional distal gastrectomy (CDG). Surgical stress, including the duration of operation (149.0±4.3 minutes) and the total volume of bleeding at operation (97.0±11.2 g), was significantly less in the PPG patients. Early postoperative complications were seen in 31% after PPG and in 35% after CDG. The most frequent complication in PPG patients was remnant gastric stasis (23%). Endoscopy showed redness or erosion (or both) of the gastric remnant in 17% after PPG and in 81% after CDG. Bile regurgitation was demonstrated in 11% after PPG and in 62% after CDG. In PPG patients, the pyloric ring opened and closed during the examination. Gastric pH was 4.2±0.4 in PPG patients but was significantly lower in CDG patients. The resting gallbladder area, examined by ultrasonography, demonstrated no changes after PPG but was significantly enlarged after CDG (from 11.3±1.2 cm2 to 15.8±1.5 cm2 at 2 weeks). The percentage of the original resting gallbladder area at 20 minutes after injection of cerulein increased slightly in PPG patients but recovered thereafter, whereas in CDG patients it increased significantly (from 39.4±8.3% to 66.7±9.1% at 2 weeks). No gallstone formation was detected throughout the observation period after PPG, whereas after CDG it was detected in two patients at 1 year. These results indicated that PPG for gastric cancer has advantages over CDG in terms of surgical stress, the condition of the gastric remnant, and gallbladder function.

Tài liệu tham khảo

Maki, T., Shiratori, T., Harafuku T., Sugawara, K.: Pylorus-preserving gastrectomy as an improved operation for gastric ulcer. Surgery 61:838, 1967 Sekine, T., Sato, T., Maki, T., Shiratori, T.: Pylorus-preserving gastrectomy for gastric ulcer: one to nine year follow-up study. Surgery 77:92, 1975 Sugiyama, Y., Sohma, H., Ozawa, M., et al.: Regurgitant bile acids and mucosal injury of the gastric remnant after partial gastrectomy. Am. J. Surg. 153:399, 1987 Langhans, P., Hegar, R.A., Hohenstein, J., Schlake, W., Bunte, H.: Operation-sequel carcinoma of the stomach: experimental studies of surgical techniques with or without resection. World J. Surg. 5:595, 1981 Kodama, M., Koyama, K.: Indication for pylorus preserving gastrectomy for early gastric cancer located in the middle third of the stomach. World J. Surg. 15:628, 1991 Ohnishi, A.: Electrophysiolosical studies on the motility of the preserved pylorus after pylorus preserving gastrectomy in dog. J. Kyoto Prefectural Univ. Med. 87:197, 1978 Suzuki, E.: Interdigestive contractile characteristics of canine pylorus and gastroduodenal regions. J. Smooth Muscle Res. 27:139, 1991 Braasch, J., Rossi, R., Watkins, E., Jr., Desiel, D., Winter, P.: Pylorus and gastric preserving pancreatic resection: experience with 87 patients. Ann. Surg. 204:411, 1986 Chen, D., Onda, M., Moriyama, Y., Nakajima, Y.: Immunohistochemical studies on damage of intestinal nerve plexuses in ischemic state. Jpn. J. Gstroenterol. Surg. 25:2732, 1992 Horwitz, A., Kirson, S.M.: Cholecystitis and cholelithiasis as a sequel to gastric surgery: a clinical impression. Am. J. Surg. 109:760, 1965 Tompkins, R.K., Kraft, A.R., Zimmerman, E., Lichtenstein, J.E., Zollinger, R.M.: Clinical and biochemical evidence of increased gallstone formation after complete vagotomy. Surgery 71:196, 1972 Cox, H.T., Doherty, J.F., Kerr, D.F.: Changes in the gallbladder after elective gastric surgery. Lancet 1:764, 1958 Fletcher, D.M., Clark, C.G.: Gallstones and gastric surgery: a review. Br. J. Surg. 55:895, 1968 Pitt, H.A., King, W., III, Mann, L.L.: Increased risk of cholecystolithiasis with prolonged parenteral nutrition. Am. J. Surg. 145:106, 1983 Johnson, F.E., Boyden, E.A.: The effect of double vagotomy on the motor activity of the human gallbladder. Surgery 32:591, 1952 Inoue, K., Fuchigami, A., Higashide, S., et al.: Gallbladder sludge and stone formation in relation to contractile function after gastrectomy: a prospective study. Ann. Surg. 215:19, 1992 Kodama, M., Koyama, H., Sone, S., Sakusabe, M., Narisawa, T., Koyama, K.: Quality of life after resection of stomach by questionnaire. J. Jpn. Soc. Clin. Surg. 51:466, 1990