Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts

Nature Medicine - Tập 12 Số 4 - Trang 452-458 - 2006
Wolfram‐Hubertus Zimmermann1, Ivan Melnychenko1, Gerald Wasmeier2, Michael Didié1, Hiroshi Naito1, Uwe Nixdorff2, Andreas Heß3, Luboš Budinský3, Kay Brune3, Bjela Michaelis4, Stefan Dhein4, Alexander Peter Schwoerer5, Heimo Ehmke5, Thomas Eschenhagen1
1Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg, 20246, Germany
2Medical Clinic II, Friedrich-Alexander-University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen, 91054, Germany
3Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University of Erlangen-Nuremberg, Fahrstraße 17, Erlangen, 91054, Germany
4Department of Cardiac Surgery, Heart Center, University of Leipzig, Strümpellstraße 39, Leipzig, 04289, Germany
5Institute of Vegetative Physiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg, 20246, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

Murry, C.E., Field, L.J. & Menasche, P. Cell-based cardiac repair: reflections at the 10-year point. Circulation 112, 3174–3183 (2005).

Eschenhagen, T. & Zimmermann, W.H. Engineering myocardial tissue. Circ. Res. 97, 1220–1231 (2005).

Reinecke, H., Zhang, M., Bartosek, T. & Murry, C.E. Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts. Circulation 100, 193–202 (1999).

Condorelli, G. et al. Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration. Proc. Natl. Acad. Sci. USA 98, 10733–10738 (2001).

Muller-Ehmsen, J. et al. Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation 105, 1720–1726 (2002).

Li, R.K. et al. Natural history of fetal rat cardiomyocytes transplanted into adult rat myocardial scar tissue. Circulation 96 Suppl., II-179–86; discussion 186–7 (1997).

Taylor, D.A. et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat. Med. 4, 929–933 (1998).

Soonpaa, M.H., Koh, G.Y., Klug, M.G. & Field, L.J. Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. Science 264, 98–101 (1994).

Assmus, B. et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 106, 3009–3017 (2002).

Orlic, D. et al. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701–705 (2001).

Stamm, C. et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361, 45–46 (2003).

Strauer, B.E. et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106, 1913–1918 (2002).

Beltrami, A.P. et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114, 763–776 (2003).

Oh, H. et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl. Acad. Sci. USA 100, 12313–12318 (2003).

Balsam, L.B. et al. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428, 668–673 (2004).

Murry, C.E. et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428, 664–668 (2004).

Nygren, J.M. et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat. Med. 10, 494–501 (2004).

Kehat, I. et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J. Clin. Invest. 108, 407–414 (2001).

Laugwitz, K.L. et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433, 647–653 (2005).

Messina, E. et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ. Res. 95, 911–921 (2004).

Eschenhagen, T. et al. Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system. FASEB J. 11, 683–694 (1997).

Zimmermann, W.H. et al. Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. Biotechnol. Bioeng. 68, 106–114 (2000).

Zimmermann, W.H. et al. Tissue engineering of a differentiated cardiac muscle construct. Circ. Res. 90, 223–230 (2002).

Carrier, R.L. et al. Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization. Biotechnol. Bioeng. 64, 580–589 (1999).

Leor, J. et al. Bioengineered cardiac grafts: A new approach to repair the infarcted myocardium? Circulation 102 Suppl. 3, III56–III61 (2000).

Li, R.K. et al. Survival and function of bioengineered cardiac grafts. Circulation 100 Suppl., II63–II69 (1999).

Zimmermann, W.H. et al. Cardiac grafting of engineered heart tissue in syngenic rats. Circulation 106, I151–I157 (2002).

Dhein, S., Muller, A., Gerwin, R. & Klaus, W. Comparative study on the proarrhythmic effects of some antiarrhythmic agents. Circulation 87, 617–630 (1993).

Menasche, P. et al. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J. Am. Coll. Cardiol. 41, 1078–1083 (2003).

Jackson, K.A. et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. 107, 1395–1402 (2001).