Selenium: Biochemical Role as a Component of Glutathione Peroxidase

American Association for the Advancement of Science (AAAS) - Tập 179 Số 4073 - Trang 588-590 - 1973
John T. Rotruck1, A. L. Pope2, Howard E. Ganther3, Anne Swanson4, Dean G. Hafeman4, W. G. Hoekstra5
1Departments of Biochemistry and Meat and Animal Science, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
2Department of Meat and Animal Science
3Department of Nutritional Sciences
4Department of Biochemistry
5Departments of Biochemistry and Nutritional Sciences

Tóm tắt

When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H 2 O 2 , added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the 75 Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.

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Tài liệu tham khảo

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American Association for the Advancement of Science (AAAS)

Tập 179 Số 4073

588-590

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