Delivery Room Management of the Apparently Vigorous Meconium-stained Neonate: Results of the Multicenter, International Collaborative Trial

American Academy of Pediatrics (AAP) - Tập 105 Số 1 - Trang 1-7 - 2000
Thomas E. Wiswell1, Catherine M. Gannon1, Jack Jacob2, Leonard S. Goldsmith3, Edgardo Szyld4, Kerry Weiss5, David L. Schutzman6, Gerard M Cleary1, Panayot Filipov7, Isabel Kurlat8, Carlos L. Caballero9, Soraya Abassi10, Daniel Sprague11, Charles Oltorf12, Michael Padula1
1From the Neonatology services at Thomas Jefferson University, Philadelphia, Pennsylvania;
2Providence Alaska Medical Center, Anchorage, Alaska
3West Jersey Hospital, Voorhees, New Jersey;
4Diego Paroissien Hospital, Buenos Aires, Argentina
5Mercer Medical Center, Trenton, New Jersey;
6Fitzgerald Mercy Hospital, Darby, Pennsylvania;
7Flushing Hospital, Flushing, New York;
8University Hospital, Buenos Aires, Argentina;
9Clinicas Hospital, Asúncion, Paraguay;
10Pennsylvania Hospital, Philadelphia, Pennsylvania
11Desert Samaritan Medical Center, Phoenix, Arizona; and
12Scott and White Memorial Hospital, Temple Texas

Tóm tắt

Objective. Disagreement exists concerning the appropriate delivery room management of the airway of vigorous meconium-stained infants. Some suggest a universal approach to intubation and suctioning of the airway in all such neonates, whereas others advocate a selective approach. We performed this investigation: 1) to assess whether intubation and suctioning of apparently vigorous, meconium-stained neonates would reduce the incidence of meconium aspiration syndrome (MAS); and 2) to determine the frequency of complications from delivery room intubation and suctioning of such infants.Methods. Inclusion criteria included: 1) gestational age ≥37 weeks; 2) birth through meconium-stained amniotic fluid of any consistency; and 3) apparent vigor immediately after birth. Subjects were randomized to be intubated and suctioned (INT) or to expectant management (EXP). Primary outcome measures included: 1) the incidence of respiratory distress, including MAS, and 2) the incidence of complications from intubation.Results. A total of 2094 neonates were enrolled from 12 participating centers (1051 INT and 1043 EXP). Meconium-stained amniotic fluid consistency was similar in both groups. Of the 149 (7.1%) infants that subsequently demonstrated respiratory distress, 62 (3.0%) had MAS and 87 (4.2%) had findings attributed to other disorders. There were no significant differences between groups in the occurrence of MAS (INT = 3.2%; EXP = 2.7%) or in the development of other respiratory disorders (INT = 3.8%; EXP = 4.5%). Of 1098 successfully intubated infants, 42 (3.8%) had a total of 51 complications of the procedure. In all cases, the complications were mild and transient in nature.Conclusions. Compared with expectant management, intubation and suctioning of the apparently vigorous meconium-stained infant does not result in a decreased incidence of MAS or other respiratory disorders. Complications of intubation are infrequent and short-lived.

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American Academy of Pediatrics (AAP)

Tập 105 Số 1

1-7

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