Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL

Blood - Tập 132 Số 8 - Trang 804-814 - 2018
John M. Rossi1, Patrick Paczkowski2, Yueh-wei Shen1, Kevin Morse2, Brianna Flynn2, Alaina Kaiser2, Colin Ng2, Kyle Gallatin2, Tom Cain2, Rong Fan3, Sean Mackay2, James R. Heath4, Steven A. Rosenberg5, James N. Kochenderfer6, Jing Zhou2, Adrian Bot1
1Kite, A Gilead Company, Santa Monica, CA
2Isoplexis, Branford, CT
3Department of Biomedical Engineering, Yale School of Engineering and Applied Science, Yale University, New Haven, CT;
4Divison of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA; and
5Surgery Branch, and
6Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD

Tóm tắt

Key Points The PSI of manufactured CAR T cells was associated with clinical response and toxicities. Monitoring CAR T-cell polyfunctionality as a key product attribute may complement other characteristics including T-cell proliferation.

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Tài liệu tham khảo

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