The Challenge of Finding a Cure for HIV Infection

American Association for the Advancement of Science (AAAS) - Tập 323 Số 5919 - Trang 1304-1307 - 2009
Douglas D. Richman1,2,3,4,5, David M. Margolis1,2,3,4,5, Martin Delaney1,2,3,4,5, Warner C. Greene1,2,3,4,5, Daria J. Hazuda1,2,3,4,5, Roger J. Pomerantz1,2,3,4,5
1Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
2Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, and University of California at San Francisco, San Francisco, CA 94143, USA.
3Merck and Co., West Point, PA 19486, USA.
4Project Inform, 1375 Mission Street, San Francisco, CA 94103, USA.
5San Diego VA Healthcare System and University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0679, USA.

Tóm tắt

Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent infection in reservoirs such as latently infected CD4 + lymphocytes and cells of the macrophage-monocyte lineage. Despite its success, chronic suppressive therapy is limited by its cost, the requirement of lifelong adherence, and the unknown effects of long-term treatment. This review discusses our current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure.

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We acknowledge the encouragement and support of C. Dieffenbach of the Division of AIDS National Institute of Allergy and Infectious Diseases NIH and V. Miller and the Forum for Collaborative HIV Research. We also thank J. C. W. Carroll from the J. David Gladstone Institutes for graphic artwork. This article is dedicated to the memory of our friend and colleague Martin Delaney.

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American Association for the Advancement of Science (AAAS)

Tập 323 Số 5919

1304-1307

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