Single HCC between 2 and 5 cm: the grey zone
Tóm tắt
Long term survival of single nodular hepatocellular carcinoma (HCC) measuring 2–5 cm in size treated with radiofrequency ablation (RFA) was compared between 157 HCCs treated with RFA and 89 HCCs treated by operation. The 5 year survival rate was not significantly different between RFA and operation. In addition, the 17th nationwide survey of the Liver Cancer Study Group of Japan clearly showed that 5 year survival rate in 858 HCCs measuring 2–5 cm in size treated with RFA was similar to that in 6,574 HCCs measuring 2–5 cm in size treated by operation. In conclusion, RFA achieves outcomes similar to those of operation for Child-Pugh A patients with HCCs measuring 2–5 cm in size.
Tài liệu tham khảo
Bruix J, Sherman M, Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma. Hepatology. 2005;42:1208–36.
Bruix J, Sherman M, Llovet JM, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL Conference. J Hepatol. 2001;35:421–30.
Makuuchi M. Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan. Hepatol Res. 2008;38:37–51.
Kudo M, Okanoue T, Japan Society of Hepatology. Management of hepatocellular carcinoma in Japan: consensus-based clinical practice manual proposed by the Japan Society of Hepatology. Oncology. 2007;72:S2–15.
Ikai I, Arii S, Okazaki M, Okita K, Omata M, Kojiro M, et al. Report of the 17th Nationwide Follow-up Survey of Primary Liver Cancer in Japan. Hepatol Res. 2007;37:676–91.
Takahashi S, Kudo M, Chung H, Inoue T, Nagashima M, Kitai S, et al. Outcomes of nontransplant potentially curative therapy for early-stage hepatocellular carcinoma in Child-Pugh Stage A cirrhosis is comparable with liver transplantation. Dig Dis. 2007;25:303–9.
Eguchi S, Kanematsu T, Arii S, Okazaki K, Omata M, Ikai I, et al. Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey. Surgery. 2008;143:469–75.
Poon RT. Liver transplantation for solitary hepatocellular carcinoma less than 3 cm in diameter in Child A cirrhosis. Dig Dis. 2007;25:334–40.