Mating Stimuli Influence Endogenous Variations in the Neurosteroids 3α,5α‐THP and 3α‐Diol

Journal of Neuroendocrinology - Tập 11 Số 11 - Trang 839-847 - 1999
C A Frye1, Bayon2
1Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
2Dept. of Psychology, The University at Albany, SUNY, Albany, NY, USA

Tóm tắt

Progesterone facilitates and 5α‐dihydrotestosterone (DHT) inhibits female sexual behaviour in rodents; their metabolites, 5α‐pregnan‐3α‐ol‐20‐one (3α,5α‐THP) and 5α‐androstane‐3α‐17β‐Diol (3α‐Diol), may influence the onset and termination of lordosis. Changes in these and related steroids in hormonal states associated with differences in receptivity were investigated. Rats were assigned to oestrus, metoestrus, dioestrus, pro‐oestrus, mated, gestational days 5–7, 12–14, 18–20, or post‐partum conditions; rats 9+ months of age were considered older. Pro‐oestrus rats were exposed to the mating arena, sight and smell of a male with no tactile contact, artificial vaginocervical stimulation, standard mating, or no mating. Progesterone, 5α‐pregnane‐3,20‐dione, 3α,5α‐THP, oestradiol, testosterone, DHT, 3α‐Diol, dehydroepiandrosterone, and corticosterone were measured in plasma and whole brain, midbrain, hypothalamus, cortex, amygdala, hippocampus. 3α,5α‐THP and 3α‐Diol changed with reproductive state and mating stimuli. Plasma and whole brain 3α,5α‐THP and 3α‐Diol were significantly increased in pro‐oestrus versus dioestrus rats; plasma 3α,5α‐THP was decreased and 3α‐Diol increased in mated versus pro‐oestrus rats. The midbrain and hypothalamus had the most evident changes in 3α,5α‐THP and 3α‐Diol between dioestrus versus pro‐oestrus and pro‐oestrus versus mated rats. 3α,5α‐THP and 3α‐Diol were altered differently in response to mating stimuli. 3α,5α‐THP was greater in the midbrain of mated versus pro‐oestrus rats; other mating‐relevant stimuli decreased 3α,5α‐THP. Midbrain 3α‐Diol was increased with exposure to a male <VCS< mating. 3α,5α‐THP was increased and 3α‐Diol was decreased in the hypothalamus of mated versus pro‐oestrus rats; exposure to the various mating stimuli decreased 3α,5α‐THP and 3α‐Diol. The neurosteroids, 3α,5α‐THP and 3α‐Diol, vary with mating in the hypothalamus and midbrain of rats.

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Journal of Neuroendocrinology

Tập 11 Số 11

839-847

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