Homeobox genes in mammary gland development and neoplasia

Breast Cancer Research - Tập 2 Số 3 - 2000
Michael T. Lewis1
1Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Room 3802, Box C240, Denver, CO, 80262, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Daniel CW, Silberstein GB: Developmental biology of the mammary gland. The Mammary Gland. 1987, 3-36.

Sakakura T: Mammary embryogenesis. The Mammary Gland. 1987, 37-66.

Russo J, Russo IH: Development of the human mammary gland. The Mammary Gland. 1987, 67-93.

Manak JR, Scott MP: A class act: conservation of homeodomain protein functions. Dev Suppl. 1994, 61-77.

Thesleff I, Vaahtokari A, Partanen AM: Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs. Int J Dev Biol. 1995, 39: 35-50.

Capecchi MR: Hox genes and mammalian development. Cold Spring Harb Symp Quant Biol. 1997, 62: 273-281.

Mark M, Rijli FM, Chambon P: Homeobox genes in embryogenesis and pathogenesis. Pediatr Res. 1997, 42: 421-429.

Burglin TR: Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucl Acids Res. 1997, 25: 4173-4180. 10.1093/nar/25.21.4173.

Scott MP, Tamkun JW, Hartzell GWd: The structure and function of the homeodomain. Biochim Biophys Acta. 1989, 989: 25-48. 10.1016/0304-419X(89)90033-4.

Stein S, Fritsch R, Lemaire L, Kessel M: Checklist: vertebrate homeobox genes. Mech Dev. 1996, 55: 91-108. 10.1016/0925-4773(95)00494-7.

Mannervik M: Target genes of homeodomain proteins. Bioessays. 1999, 21: 267-270. 10.1002/(SICI)1521-1878(199904)21:4<267::AID-BIES1>3.0.CO;2-C.

Schumacher A, Magnuson T: Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet. 1997, 13: 167-170. 10.1016/S0168-9525(97)01133-5.

Kennison JA, Tamkun JW: Trans-regulation of homeotic genes in Drosophila. New Biol. 1992, 4: 91-96.

Kennison JA: The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet. 1995, 29: 289-303. 10.1146/annurev.ge.29.120195.001445.

Hanson RD, Hess JL, Yu BD, et al: Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci USA. 1999, 96: 14372-14377. 10.1073/pnas.96.25.14372.

Tabin CJ: Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs. Development. 1992, 116: 289-296.

Zakany J, Fromental-Ramain C, Warot X, Duboule D: Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications. Proc Natl Acad Sci USA. 1997, 94: 13695-13700. 10.1073/pnas.94.25.13695.

Chang CP, Jacobs Y, Nakamura T, Jenkins NA, Copeland NG, Cleary ML: Meis proteins are major in vivo DNA binding partners for wildtype but not chimeric Pbx proteins. Mol Cell Biol. 1997, 17: 5679-5687.

Phelan ML, Rambaldi I, Featherstone MS: Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol Cell Biol. 1995, 15: 3989-3997.

Mann RS: The specificity of homeotic gene function. Bioessays. 1995, 17: 855-863.

Stuart ET, Yokota Y, Gruss P: PAX and HOX in neoplasia. Adv Genet. 1995, 33: 255-274.

Ford HL: Homeobox genes: a link between development, cell cycle, and cancer?. Cell Biol Int. 1998, 22: 397-400. 10.1006/cbir.1998.0329.

Cillo C, Faiella A, Cantile M, Boncinelli E: Homeobox genes and cancer. Exp Cell Res. 1999, 248: 1-9. 10.1006/excr.1999.4451.

Deschamps J, Meijlink F: Mammalian homeobox genes in normal development and neoplasia. Crit Rev Oncog. 1992, 3: 117-173.

van Genderen C, Okamura RM, Farinas I, et al: Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 1994, 8: 2691-2703.

Dunbar ME, Wysolmerski JJ: Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development. J Mammary Gland Biol Neoplasia. 1999, 4: 21-34. 10.1023/A:1018700502518.

Dunbar ME, Dann PR, Robinson GW, Hennighausen L, Zhang JP, Wysolmerski JJ: Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development. 1999, 126: 3485-3493.

Chepko G, Smith GH: Mammary epithelial stem cells: our current understanding. J Mammary Gland Biol Neoplasia. 1999, 4: 35-52. 10.1023/A:1018752519356.

Wewer UM, Mercurio AM, Chung SY, Albrechtsen R: Deoxyribonucleic-binding homeobox proteins are augmented in human cancer. Lab Invest. 1990, 63: 447-454.

Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M: Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. Biochem Pharmacol. 1994, 47: 137-143. 10.1016/0006-2952(94)90447-2.

Friedmann Y, Daniel CA, Strickland P, Daniel CW: Hox genes in normal and neoplastic mouse mammary gland. Cancer Res. 1994, 54: 5981-5985. This is the first substantive demonstration of homeobox gene expression in the intact mouse mammary gland and of altered expression on neoplastic progression.

Friedmann Y: Expression and developmental role of homeobox containing genes during mouse mammary gland morphogenesis. In Biology. 1995

Srebrow A, Friedmann Y, Ravanpay A, Daniel CW, Bissell MJ: Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem. 1998, 69: 377-391. 10.1002/(SICI)1097-4644(19980615)69:4<377::AID-JCB1>3.0.CO;2-K.

Robinson GW, Karpf AB, Kratochwil K: Regulation of mammary gland development by tissue interaction. J Mammary Gland Biol Neoplasia. 1999, 4: 9-19. 10.1023/A:1018748418447.

Rosen JM, Wyszomierski SL, Hadsell D: Regulation of milk protein gene expression. Annu Rev Nutr. 1999, 19: 407-436. 10.1146/annurev.nutr.19.1.407.

Streuli CH, Gilmore AP: Adhesion-mediated signaling in the regulation of mammary epithelial cell survival. J Mammary Gland Biol Neoplasia. 1999, 4: 183-191. 10.1023/A:1018729308878.

Weaver VM, Bissell MJ: Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia. 1999, 4: 193-201. 10.1023/A:1018781325716.

Chen F, Capecchi MR: Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci USA. 1999, 96: 541-546. 10.1073/pnas.96.2.541. This is the first demonstrated role of homeobox genes in control of mammary function

Carpenter EM, Goddard JM, Davis AP, Nguyen TP, Capecchi MR: Targeted disruption of Hoxd-10 affects mouse hindlimb development. Development. 1997, 124: 4505-4514.

Friedmann Y, Daniel CW: Regulated expression of homeobox genes Msx-1 and Msx-2 in mouse mammary gland development suggests a role in hormone action and epithelial-stromal interactions. Dev Biol. 1996, 177: 347-355. 10.1006/dbio.1996.0168. Implication of homeobox genes in hormone responses

Phippard DJ, Weber-Hall SJ, Sharpe PT, et al: Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development. 1996, 122: 2729-2737. Implication of homeobox genes in hormone responses

Brisken C, Park S, Vass T, Lydon JP, O'Malley BW, Weinberg RA: A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci USA. 1998, 95: 5076-5081. 10.1073/pnas.95.9.5076.

Lewis MT, Ross S, Strickland PA, et al: Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1 (Ptc-1). Development. 1999, 126: 5181-5193.

Wiesen JF, Young P, Werb Z, Cunha GR: Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development. 1999, 126: 335-344.

Hudson R, Taniguchi-Sidle A, Boras K, Wiggan O, Hamel PA: Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions. Dev Dyn. 1998, 213: 159-169. 10.1002/(SICI)1097-0177(199810)213:2<159::AID-AJA1>3.0.CO;2-F.

Qu S, Niswender KD, Ji Q, et al: Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development. 1997, 124: 3999-4008.

Qu S., Tucker SC, Ehrlich JS, et al: Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly. Development. 1998, 125: 2711-2721.

Lewis MT, Ross S, Strickland PA, Snyder CJ, Daniel CW: Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. Cell Tissue Res. 1999, 296: 549-554. 10.1007/s004410051316. This is the first demonstration of developmentally regulated homeobox gene expression in the intact human mammary gland.

Joyner AL, Herrup K, Auerbach BA, Davis CA, Rossant J: Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science. 1991, 251: 1239-1243.

Hanks M, Wurst W, Anson-Cartwright L, Auerbach AB, Joyner AL: Rescue of the En-1 mutant phenotype by replacement of En-1 with en-2. Science. 1995, 269: 679-682.

Loomis CA, Harris E, Michaud J, Wurst W, Hanks M, Joyner AL: The mouse Engrailed-1 gene and ventral limb patterning. Nature. 1996, 382: 360-363. 10.1038/382360a0.

Futreal PA, Cochran C, Rosenthal J, et al: Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. Hum Mol Genet. 1994, 3: 1359-1364.

Jehn B, Chicaiza G, Martin F, Jaggi R: Isolation of three novel POU-domain containing cDNA clones from lactating mouse mammary gland. Biochem Biophys Res Commun. 1994, 200: 156-162. 10.1006/bbrc.1994.1428.

Jin T, Branch DR, Zhang X, Qi S, Youngson B, Goss PE: Examination of POU homeobox gene expression in human breast cancer cells. Int J Cancer. 1999, 81: 104-112. 10.1002/(SICI)1097-0215(19990331)81:1<104::AID-IJC18>3.3.CO;2-H.

Labosky PA, Winnier GE, Jetton TL, et al: The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. Development. 1997, 124: 1263-1274.

Wehr R, Mansouri A, de Maeyer T, Gruss P: Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body. Development. 1997, 124: 4447-4456.

Care A, Silvani A, Meccia E, Mattia G, Peschle C., Colombo MP: Transduction of the SkBr3 breast carcinoma cell line with the HOXB7 gene induces bFGF expression, increases cell proliferation and reduces growth factor dependence. Oncogene. 1998, 16: 3285-3289. 10.1038/sj/onc/1201875.

Ford HL, Kabingu EN, Bump EA, Mutter GL, Pardee AB: Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIXI: a possible mechanism of breast carcinogenesis. Proc Natl Acad Sci USA. 1998, 95: 12608-12613. 10.1073/pnas.95.21.12608. This is the first indication of homeobox gene function in regulation of the cell cycle in mammary epithelial cells.

Chen X, Lowe M, Keyomarsi K: UCN-01-mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent. Oncogene. 1999, 18: 5691-5702. 10.1038/sj/onc/1202948.

Jones JM, Cui XS, Medina D, Donehower LA: Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model. Cell Growth Diff. 1999, 10: 213-222.

Larson JS, Tonkinson JL, Lai MT: A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells. Cancer Res. 1997, 57: 3351-3355.

Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB: Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA. 1992, 89: 7491-7495.

Chariot A, Moreau L, Senterre G, Sobel ME, Castronovo V: Retinoic acid induces three newly cloned HOXA1 transcripts in MCF7 breast cancer cells. Biochem Biophys Res Commun. 1995, 215: 713-720. 10.1006/bbrc.1995.2522.

Rots NY, Liu M, Anderson EC, Freedman LP: A differential screen for ligand-regulated genes: identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells. Mol Cell Biol. 1998, 18: 1911-1918.

Chariot A, Castronovo V, Le P, Gillet C, Sobel ME, Gielen J: Cloning and expression of a new HOXC6 transcript encoding a repressing protein. Biochem J. 1996, 319: 91-97.