Molecular definitions of autophagy and related processes

EMBO Journal - Tập 36 Số 13 - Trang 1811-1836 - 2017
Lorenzo Galluzzi1,2, Eric H. Baehrecke3, Andrea Ballabio4,5,6,7, Patricia Boya8, José Manuel Bravo‐San Pedro9,10,11,2, Francesco Cecconi12,13,14, Augustine M.K. Choi15, Charleen T. Chu16, Patrice Codogno17,18,19,2, María Isabel Colombo20,21, Ana María Cuervo22, Jayanta Debnath23, Vojo Deretić24, Ivan D̵ikić25,26,27, Eeva‐Liisa Eskelinen28, Gian María Fimia29, Simone Fulda30,31,32, David A. Gewirtz33,34, Douglas R. Green35, Malene Hansen36, J. Wade Harper37, Marja Jäättelä38, Terje Johansen39, Gábor Juhász40,41, Alec Kimmelman42, Claudine Kraft43, Nicholas T. Ktistakis44, Sharad Kumar45, Beth Levine46,47, Carlos López‐Otín48,49, Frank Madeo50,51, Sascha Martens43, Jennifer Martinez52, Alicia Meléndez53,54, Noboru Mizushima55, Christian Münz56, Leon O. Murphy57, Josef Penninger58, Mauro Piacentini12,59, Fulvio Reggiori60, David C. Rubinsztein61, Kevin M. Ryan62, Laura Santambrogio63, Luca Scorrano64,65, Anna Katharina Simon66,67, Hans‐Uwe Simon68, Anne Simonsen69, Nektarios Tavernarakis70,71, Sharon A. Tooze72, Tamotsu Yoshimori73,74, Junying Yuan37,75, Zhenyu Yue76, Qing Zhong46, Guido Kroemer77,9,10,11,2
1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA
2Université Paris Descartes/Paris V, Paris, France
3Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
4Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA;
5Jan and Dan Duncan Neurological Research Institute Texas Children’s Hospital Houston TX USA
6Medical Genetics, Department of Pediatrics, Federico II University, Naples, Italy
7Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy
8Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain
9Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
10INSERM U1138, Paris, France
11Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France
12Department of Biology, University of Tor Vergata, Rome, Italy
13Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy
14Unit of Cell Stress and Survival, Danish Cancer Society Research Center, Copenhagen, Denmark
15Division of Pulmonary and Critical Care Medicine Joan and Sanford I. Weill Department of Medicine Weill Cornell Medical College New York NY USA
16Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pa.USA
17CNRS, UMR8253, Paris, France
18INSERM, U1151, Paris, France
19Institut Necker-Enfants Malades (INEM), Paris, France
20Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina
21Laboratorio de Biología Celular y Molecular Instituto de Histología y Embriología (IHEM)‐CONICET Mendoza Argentina
22Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA
23Department of Pathology University of California San Francisco San Francisco CA USA
24Department of Molecular Genetics and Microbiology University of New Mexico Health Sciences Center Albuquerque NM USA
25Buchmann Institute for Molecular Life Sciences Goethe University Frankfurt Frankfurt Main Germany
26Department of Immunology and Medical Genetics University of Split School of Medicine Split Croatia
27Institute of Biochemistry II School of Medicine Goethe University Frankfurt Frankfurt Germany
28Department of Biosciences, University of Helsinki, Helsinki, Finland
29Department of Biological and Environmental Sciences and Technologies (DISTEBA), University of Salento, Lecce, Italy
30German Cancer Consortium (DKTK), Heidelberg, Germany
31German cancer Research Center (DKFZ), Heidelberg, Germany
32Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany
33Department of Pharmacology and Toxicology and Medicine Virginia Commonwealth University Richmond VA USA
34Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
35Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA
36Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA
37Department of Cell Biology, Harvard Medical School, Boston, MA, USA
38Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark
39Molecular Cancer Research Group Institute of Medical Biology University of Tromsø – The Arctic University of Norway Tromsø Norway
40Department of Anatomy, Cell and Developmental Biology Eotvos Lorand University Budapest Hungary
41Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary
42Department of Radiation Oncology Perlmutter Cancer Center NYU Langone Medical Center New York NY USA
43Max F. Perutz Laboratories Department of Biochemistry and Cell Biology Vienna Biocenter University of Vienna Vienna Austria
44Signalling Programme, Babraham Institute, Cambridge, UK
45Centre for Cancer Biology University of South Australia Adelaide SA Australia
46Center for Autophagy Research Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA
47Howard Hughes Medical Institute (HHMI) Dallas TX USA
48Centro de Investigación en Red de Cáncer Oviedo Spain
49Department de Bioquímica y Biología Molecular Facultad de Medicina Instituto Universitario de Oncología (IUOPA) Universidad de Oviedo Oviedo Spain
50BioTechMed Graz, Graz, Austria
51Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria
52Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
53Department of Biology Queens College Queens NY USA
54Graduate Center, City University of New York, New York, NY, USA
55Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan
56Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zurich, Switzerland
57Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
58Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Campus Vienna BioCentre, Vienna, Austria
59National Institute for Infectious Diseases L. Spallanzani IRCCS, Rome, Italy
60Department of Cell Biology, University Medical Center Groningen; University of Groningen, Groningen, The Netherlands
61Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
62Cancer Research UK Beatson Institute, Glasgow, UK
63Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
64Department of Biology, University of Padova, Padova, Italy
65Venetian Institute of Molecular Medicine, Padova, Italy
66Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK
67MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
68Institute of Pharmacology, University of Bern, Bern, Switzerland
69Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
70Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece
71Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece
72Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK
73Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan
74Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
75Ludwig Cancer Center Harvard Medical School Boston MA USA
76Department of Neurology Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA
77Department of Women’s and Children’s Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

Tóm tắt

AbstractOver the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy‐related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy‐related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

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