Obesity and incidence of lung cancer: A meta‐analysis

International Journal of Cancer - Tập 132 Số 5 - Trang 1162-1169 - 2013
Yang Yang1, Jia‐Yi Dong2, Ke‐kang Sun1, Lin Zhuang1, Jun Cheng1, Lili Wang3, Yang Jiao1,4
1Laboratory of Tumor Radiobiology, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, People's Republic of China
2Department of Nutrition and Food Hygiene, School of Public Health, Medical College of Soochow University, Suzhou, People's Republic of China
3Department of Radiotherapy, the First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China
4Tel.: 86-512-6588-0050,

Tóm tắt

AbstractTo date, the relationship between obesity and the incidence of lung cancer remains unclear and inconclusive. Thus, we conducted a meta‐analysis of published studies to provide a quantitative evaluation of this association. Relevant studies were identified through PubMed and EMBASE databases from 1966 to December 2011, as well as through the reference lists of retrieved articles. A total of 31 articles were included in this meta‐analysis. Overall, excess body weight (body mass index, BMI ≥ 25 kg/m2) was inversely associated with lung cancer incidence (relative risk, RR = 0.79; 95% confidence interval, CI: 0.73–0.85) compared with normal weight (BMI = 18.5‐24.9 kg/m2). The association did not change with stratification by sex, study population, study design, and BMI measurement method. However, when stratified by smoking status, the inverse association between excess body weight and lung cancer incidence in current (RR = 0.63, 95% CI: 0.57–0.70) and former (RR = 0.73, 95% CI: 0.58–0.91) smokers was strengthened. In non‐smokers, the association was also statistically significant (RR = 0.83, 95% CI: 0.70–0.98), although the link was weakened to some extent. The stratified analyses also showed that excess body weight was inversely associated with squamous cell carcinoma (RR = 0.68, 95% CI: 0.58–0.80) and adenocarcinoma (RR = 0.79, 95% CI: 0.65–0.96). No statistically significant link was found between excess body weight and small cell carcinoma (RR = 0.99, 95% CI: 0.66–1.48). The results of this meta‐analysis indicate that overweight and obesity are protective factors against lung cancer, especially in current and former smokers.

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Thông tin xuất bản

International Journal of Cancer

Tập 132 Số 5

1162-1169

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