Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids

Wiley - Tập 35 Số 3 - Trang 161-214 - 1990
Gregg Fields1, Richard L. Noble2
1Department of Pharmaceutical Chemistry, University of California, San Francisco
2Applied Biosystems. Inc., Foster City, Calgornia, USA

Tóm tắt

9‐Fluorenylmethoxycarbonyl (Fmoc) amino acids were first used for solid phase peptide synthesis a little more than a decade ago. Since that time, Fmoc solid phase peptide synthesis methodology has been greatly enhanced by the introduction of a variety of solid supports, linkages, and side chain protecting groups, as well as by increased understanding of solvation conditions. These advances have led to many impressive syntheses, such as those of biologically active and isotopically labeled peptides and small proteins. The great variety of conditions under which Fmoc solid phase peptide synthesis may be carried out represents a truly “orthogonal” scheme, and thus offers many unique opportunities for bioorganic chemistry.

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