Abnormal white matter appearance on term FLAIR predicts neuro‐developmental outcome at 6 years old following preterm birth

International Journal of Developmental Neuroscience - Tập 25 - Trang 523-530 - 2007
Sachiko Iwata1,2,3, Osuke Iwata1,2,3, Alan Bainbridge4, Tomohiko Nakamura2, Hideki Kihara2, Eriko Hizume2, Masatoshi Sugiura2, Masanori Tamura2, Toyojiro Matsuishi1
1Department of Pediatrics and Child Health, Center for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011 Japan
2Division of Neonatology, Nagano Children's Hospital, Nagano, Japan
3Centre for Perinatal Brain Research, Institute for Women's Health, University College London, UK
4Department of Medical Physics and Bio-Engineering, University College London, UK

Tóm tắt

AbstractPreterm infants are at significant risk of neuro‐developmental disorders at school‐age. MRI is a potentially useful screening tool of such disorders. Using FLAIR imaging in the preterm infants at term, here we demonstrate that abnormal low‐intensity signal in the white matter predicts the neuro‐developmental outcome at 6 years.Study designClinical factors associated with white matter appearance on MRI obtained at term were investigated in 210 preterm infants.ResultsLow‐intensity signal on FLAIR imaging was commonly observed (69%) at <2 months corrected‐age. Its incidence correlated with corrected‐age at scan, maternal pyrexia and cystic periventricular leukomalacia. Low‐intensity signal on FLAIR significantly correlated with performance and full‐scale developmental quotients, whereas diffuse high‐intensity signal on T2‐weighted imaging correlated only with the full‐scale developmental quotient at 6 years (n = 75, WISC‐R). FLAIR imaging, but not T2‐weighted imaging, predicted mild neuro‐developmental delay.ConclusionsFLAIR appeared to detect subtle white matter injury related with neuro‐developmental disorders at school‐age, whereas T2‐weighted imaging seemed to identify relatively more severe injury. FLAIR is a potentially sensitive screening tool that is readily available and easily interpretable.

Tài liệu tham khảo

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International Journal of Developmental Neuroscience

Tập 25

523-530

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