Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

American Association for the Advancement of Science (AAAS) - Tập 252 Số 5004 - Trang 443-446 - 1991
Elizabeth Finch1,2, Timothy J. Turner3, Stanley M. Goldin4
1Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
2Program in Neuroscience, Department of Neurobiology, Harvard Medical School, Boston, MA 02115
3Department of Physiology, Tufts University School of Medicine, Boston, MA 02111.
4Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115

Tóm tắt

Inositol 1,4,5-trisphosphate (IP 3 )-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium levels. The subsecond kinetics and regulation of IP 3 -induced calcium-45 release from synaptosome-derived microsomal vesicles were resolved by rapid superfusion. Extravesicular calcium acted as a coagonist, potentiating the transient IP 3 -induced release of calcium-45. Thus, rapid elevation of cytosolic calcium levels may trigger IP 3 -induced calcium release in vivo. Extravesicular calcium also produced a more slowly developing, reversible inhibition of IP 3 -induced calcium-45 release. Sequential positive and negative feedback regulation by calcium of IP 3 -induced calcium release may contribute to transients and oscillations of cytosolic-free calcium in vivo.

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American Association for the Advancement of Science (AAAS)

Tập 252 Số 5004

443-446

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