The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Alzheimer's & Dementia - Tập 7 - Trang 263-269 - 2011
Guy M. McKhann1,2, David S. Knopman3, Howard Chertkow4,5, Bradley T. Hyman6, Clifford R. Jack7, Claudia H. Kawas8,9,10, William E. Klunk11, Walter J. Koroshetz12, Jennifer J. Manly13,14,15, Richard Mayeux13,14,15, Richard C. Mohs16, John C. Morris17, Martin N. Rossor18, Philip Scheltens19, Maria C. Carrillo20, Bill Thies20, Sandra Weintraub21,22, Creighton H. Phelps23
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA
3Department of Neurology, Mayo Clinic, Rochester, MN, USA
4Department of Neurology, McGill University School of Medicine, Montreal, QC, Canada
5Bloomfield Centre for Research in Aging, Lady Davis Institute, Montreal, QC, Canada
6Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
7Department of Radiology, Mayo Clinic, Rochester, MN, USA
8Department of Neurology, University of California, Irvine, CA, USA
9Department of Neurobiology and Behavior, University of California, Irvine, CA, USA
10Alzheimer Disease Research Center, University of California, Irvine, CA, USA
11Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
12National Institute of Neurological Disorders and Stroke, Bethesda, MD USA
13Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
14Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA
15Department of Neurology, Columbia University Medical Center, New York, NY, USA
16Eli Lilly and Company, Indianapolis, IN, USA
17Department of Neurology, Washington University School of Medicine, St. Louis, Mo. USA
18Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom
19Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
20Alzheimer's Association Chicago IL USA
21Department of Psychiatry, Northwestern Feinberg School of Medicine, Chicago, IL, USA
22Department of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL, USA
23Alzheimer's Disease Centers Program, National Institute on Aging, Bethesda, MD, USA

Tóm tắt

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available. We present criteria for all‐cause dementia and for AD dementia. We retained the general framework of probable AD dementia from the 1984 criteria. On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the term possible AD dementia, but redefined it in a manner more focused than before. Biomarker evidence was also integrated into the diagnostic formulations for probable and possible AD dementia for use in research settings. The core clinical criteria for AD dementia will continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the pathophysiological specificity of the diagnosis of AD dementia. Much work lies ahead for validating the biomarker diagnosis of AD dementia.

Tài liệu tham khảo

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