A meta‐analysis of association studies between the 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR of dopamine transporter gene and attention deficit hyperactivity disorder

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 144B Số 4 - Trang 541-550 - 2007
Binrang Yang1,2, Raymond C. K. Chan2,3, Jing Jin4, Tao Li5,6, Pak C. Sham7,5, Ronald Y.L. Chen7
1Department of Sociology, Sun Yat-Sen University, Guangzhou, China
2Neuropsychology and Applied Cognitive Neuroscience Laboratory, Department of Psychology, Sun Yat-Sen University, Guangzhou, China
3Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, China
4School of Public Health, Sun Yat-sen University, Guangzhou, China
5Division of Psychological Medicine, MRC SGDP centre, Institute of Psychiatry, London, United Kingdom
6Psychiatric laboratory & Department of Psychiatry, West China Hospital, Sichuan University, Sichuan Chengdu, P.R. China
7Department of Psychiatry, The University of Hong Kong, China

Tóm tắt

AbstractThe association between the 10‐repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta‐analysis of the association between the 10‐repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3′‐untranslated region (UTR) of the DAT1 gene and ADHD. We pooled up 18 published transmission disequilibrium test (TDT) studies between the 40‐base pair VNTR polymorphism in the3′‐UTR of the DAT1 gene and ADHD. It included a total of 1,373 informative meioses, 7 haplotype‐based haplotype relative risk (HHRR) studies, and 6 case‐control‐based association studies. There were statistically significant evidences for heterogeneity of the odds ratio in TDT and HHRR studies (P < 0.10), but not in case‐control studies. The results of random effects model showed small but significant association between ADHD and the DAT1 gene in TDT studies (OR = 1.17, 95% CI = 1.05–1.30, chi‐square = 8.11, df = 1, P = 0.004), but not in HHRR and case‐control studies. The 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR the DAT1 gene has a small but significant role in the genetic susceptibility of ADHD. These meta‐analysis findings support the involvement of the dopamine system genes in ADHD liability variation. However, more work is required to further identify the functional allelic variants/mutations that are responsible for this association. © 2006 Wiley‐Liss, Inc.

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American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Tập 144B Số 4

541-550

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