Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms

Raghavan, 2010, Mitotic recombination in haematological malignancy., Adv Enzyme Regul, 50, 96, 10.1016/j.advenzreg.2009.10.030 Gupta, 2008, Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia., Genes Chromosomes Cancer, 47, 729, 10.1002/gcc.20573 Grand, 2009, Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms., Blood, 113, 6182, 10.1182/blood-2008-12-194548 Sanada, 2009, Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms., Nature, 460, 904, 10.1038/nature08240 Ernst, 2010, Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders., Nat Genet, 42, 722, 10.1038/ng.621 Nikoloski, 2010, Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes., Nat Genet, 42, 665, 10.1038/ng.620 Grossmann, 2011, Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with T.E.T2 and EZH2 being of high prognostic relevance., Leukemia, 25, 877, 10.1038/leu.2011.10 Bejar, 2011, Clinical effect of point mutations in myelodysplastic syndromes., N Engl J Med, 364, 2496, 10.1056/NEJMoa1013343 Guglielmelli, 2011, EZH2 mutational status predicts poor survival in myelofibrosis., Blood, 118, 5227, 10.1182/blood-2011-06-363424 Bracken, 2009, Polycomb group proteins: navigators of lineage pathways led astray in cancer., Nat Rev Cancer, 9, 773, 10.1038/nrc2736 Sauvageau, 2010, Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer., Cell Stem Cell, 7, 299, 10.1016/j.stem.2010.08.002 Peng, 2009, Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells., Cell, 139, 1290, 10.1016/j.cell.2009.12.002 Pasini, 2010, JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells., Nature, 464, 306, 10.1038/nature08788 Li, 2010, Jarid2 and PRC2, partners in regulating gene expression., Genes Dev, 24, 368, 10.1101/gad.1886410 Sparmann, 2006, Polycomb silencers control cell fate, development and cancer., Nat Rev Cancer, 6, 846, 10.1038/nrc1991 Varambally, 2008, Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer., Science, 322, 1695, 10.1126/science.1165395 Morin, 2010, Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin., Nat Genet, 42, 181, 10.1038/ng.518 Sneeringer, 2010, Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas., Proc Natl Acad Sci U S A, 107, 20980, 10.1073/pnas.1012525107 Yap, 2011, Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation., Blood, 117, 2451, 10.1182/blood-2010-11-321208 Stegelmann, 2010, High-resolution single-nucleotide polymorphism array-profiling in myeloproliferative neoplasms identifies novel genomic aberrations., Haematologica, 95, 666, 10.3324/haematol.2009.013623 White, 2007, Methylation-sensitive high-resolution melting-curve analysis of the SNRPN gene as a diagnostic screen for Prader-Willi and Angelman syndromes., Clin Chem, 53, 1960, 10.1373/clinchem.2007.093351 Margueron, 2008, Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms., Mol Cell, 32, 503, 10.1016/j.molcel.2008.11.004 Shen, 2008, EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency., Mol Cell, 32, 491, 10.1016/j.molcel.2008.10.016 Pasmant, 2010, NF1 microdeletions in neurofibromatosis type 1: from genotype to phenotype., Hum Mutat, 31, E1506, 10.1002/humu.21271 Langemeijer, 2009, Acquired mutations in T.E.T2 are common in myelodysplastic syndromes., Nat Genet, 41, 838, 10.1038/ng.391 Su, 2005, Polycomb group protein ezh2 controls actin polymerization and cell signaling., Cell, 121, 425, 10.1016/j.cell.2005.02.029 Reiter, 2009, Molecular basis of myelodysplastic/myeloproliferative neoplasms., Haematologica, 94, 1634, 10.3324/haematol.2009.014001 Bader, 1978, Neurofibromatosis and childhood leukemia., J Pediatr, 92, 925, 10.1016/S0022-3476(78)80362-X Balgobind, 2008, Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis., Blood, 111, 4322, 10.1182/blood-2007-06-095075 Parkin, 2010, NF1 inactivation in adult acute myelogenous leukemia., Clin Cancer Res, 16, 4135, 10.1158/1078-0432.CCR-09-2639 Le, 2004, Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder., Blood, 103, 4243, 10.1182/blood-2003-08-2650 Majewski, 2008, Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity., PLoS Biol, 6, e93, 10.1371/journal.pbio.0060093 Koontz, 2001, Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors., Proc Natl Acad Sci U S A, 98, 6348, 10.1073/pnas.101132598 Yamamoto, 2004, Polycomb group suppressor of zeste 12 links heterochromatin protein 1alpha and enhancer of zeste 2., J Biol Chem, 279, 401, 10.1074/jbc.M307344200 Tie, 1998, The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and colocalize at multiple chromosomal sites., Development, 125, 3483, 10.1242/dev.125.17.3483 Sanger Institute Catalog of Somatic Mutations in Cancer Accessed July 12, 2011 Available from: www.sanger.ac.uk/genetics/CGP/cosmic/ Lessard, 1999, Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation., Genes Dev, 13, 2691, 10.1101/gad.13.20.2691