Tissue tolerance: a distinct concept to control acute GVHD severity

Blazar, 2012, Advances in graft-versus-host disease biology and therapy, Nat Rev Immunol, 12, 443, 10.1038/nri3212 Soares, 2014, Tissue damage control in disease tolerance, Trends Immunol, 35, 483, 10.1016/j.it.2014.08.001 Ayres, 2012, Tolerance of infections, Annu Rev Immunol, 30, 271, 10.1146/annurev-immunol-020711-075030 Medzhitov, 2012, Disease tolerance as a defense strategy, Science, 335, 936, 10.1126/science.1214935 Schneider, 2008, Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases, Nat Rev Immunol, 8, 889, 10.1038/nri2432 Caldwell, 1958, Tolerance to cereal leaf rusts, Science, 128, 714, 10.1126/science.128.3326.714 Schafer, 1971, Tolerance to plant disease, Annu Rev Phytopathol, 9, 235, 10.1146/annurev.py.09.090171.001315 Kover, 2002, Genetic variation for disease resistance and tolerance among Arabidopsis thaliana accessions, Proc Natl Acad Sci USA, 99, 11270, 10.1073/pnas.102288999 Schwachtje, 2006, SNF1-related kinases allow plants to tolerate herbivory by allocating carbon to roots, Proc Natl Acad Sci USA, 103, 12935, 10.1073/pnas.0602316103 Richardson, 2010, An essential role for XBP-1 in host protection against immune activation in C. elegans, Nature, 463, 1092, 10.1038/nature08762 Dionne, 2006, Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila, Curr Biol, 16, 1977, 10.1016/j.cub.2006.08.052 Van der Sluis, 2006, Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection, Gastroenterology, 131, 117, 10.1053/j.gastro.2006.04.020 Velcich, 2002, Colorectal cancer in mice genetically deficient in the mucin Muc2, Science, 295, 1726, 10.1126/science.1069094 Ferreira, 2008, A central role for free heme in the pathogenesis of severe malaria: the missing link?, J Mol Med (Berl), 86, 1097, 10.1007/s00109-008-0368-5 Herbert, 2004, Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology, Immunity, 20, 623, 10.1016/S1074-7613(04)00107-4 Wambua, 2006, The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya, PLoS Med, 3, e158, 10.1371/journal.pmed.0030158 Mathieu Wang Lynch, 2008, Accommodation in organ transplantation, Curr Opin Organ Transplant, 13, 165, 10.1097/MOT.0b013e3282f6391e Lynch, 2010, Accommodation in renal transplantation: unanswered questions, Curr Opin Organ Transplant, 15, 481, 10.1097/MOT.0b013e32833b9c25 Matzinger, 2007, Friendly and dangerous signals: is the tissue in control?, Nat Immunol, 8, 11, 10.1038/ni0107-11 Matzinger, 2011, Tissue-based class control: the other side of tolerance, Nat Rev Immunol, 11, 221, 10.1038/nri2940 Ramsay, 1982, A randomized study of the prevention of acute graft-versus-host disease, N Engl J Med, 306, 392, 10.1056/NEJM198202183060703 Weisdorf, 1990, Treatment of moderate/severe acute graft-versus-host disease after allogeneic bone marrow transplantation: an analysis of clinical risk features and outcome, Blood, 75, 1024, 10.1182/blood.V75.4.1024.1024 Martin, 1991, A retrospective analysis of therapy for acute graft-versus-host disease: secondary treatment, Blood, 77, 1821, 10.1182/blood.V77.8.1821.1821 Chao, 1993, Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease, N Engl J Med, 329, 1225, 10.1056/NEJM199310213291703 Hings, 1994, Treatment of moderate and severe acute GVHD after allogeneic bone marrow transplantation, Transplantation, 58, 437, 10.1097/00007890-199408270-00008 Przepiorka, 1996, Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after matched unrelated donor marrow transplantation, Blood, 88, 4383, 10.1182/blood.V88.11.4383.4383 MacMillan, 2002, Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: comparison of grading systems, Biol Blood Marrow Transplant, 8, 387, 10.1053/bbmt.2002.v8.pm12171485 Lee, 2004, Effect of up-front daclizumab when combined with steroids for the treatment of acute graft-versus-host disease: results of a randomized trial, Blood, 104, 1559, 10.1182/blood-2004-03-0854 Levine, 2008, Etanercept plus methylprednisolone as initial therapy for acute graft-versus-host disease, Blood, 111, 2470, 10.1182/blood-2007-09-112987 Chang, 2016, Controlled, randomized, open-label trial of risk-stratified corticosteroid prevention of acute graft-versus-host disease after haploidentical transplantation, J Clin Oncol, 34, 1855, 10.1200/JCO.2015.63.8817 Gooley, 2010, Reduced mortality after allogeneic hematopoietic-cell transplantation, N Engl J Med, 363, 2091, 10.1056/NEJMoa1004383 van Bekkum, 1974, Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora, J Natl Cancer Inst, 52, 401, 10.1093/jnci/52.2.401 Eriguchi, 2012, Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins, Blood, 120, 223, 10.1182/blood-2011-12-401166 Jenq, 2012, Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation, J Exp Med, 209, 903, 10.1084/jem.20112408 Shono, 2016, Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice, Sci Transl Med, 8, 339ra71, 10.1126/scitranslmed.aaf2311 Maloy, 2011, Intestinal homeostasis and its breakdown in inflammatory bowel disease, Nature, 474, 298, 10.1038/nature10208 Kabat, 2014, Modulation of immune development and function by intestinal microbiota, Trends Immunol, 35, 507, 10.1016/j.it.2014.07.010 Rooks, 2016, Gut microbiota, metabolites and host immunity, Nat Rev Immunol, 16, 341, 10.1038/nri.2016.42 Mathewson, 2016, Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease, Nat Immunol, 17, 505, 10.1038/ni.3400 Furusawa, 2013, Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells, Nature, 504, 446, 10.1038/nature12721 Toubai, 2015, NLRP6 in host target tissues exacerbates graft-versus-host disease [abstract], Blood, 126, 148, 10.1182/blood.V126.23.148.148 Yang, 2004, Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse, J Immunol, 172, 4151, 10.4049/jimmunol.172.7.4151 Panoskaltsis-Mortari, 1998, Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice, Blood, 92, 3960, 10.1182/blood.V92.10.3960.422k29_3960_3967 Krijanovski, 1999, Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease, Blood, 94, 825, 10.1182/blood.V94.2.825 Vanclée, 2005, Keratinocyte growth factor ameliorates acute graft-versus-host disease in a novel nonmyeloablative haploidentical transplantation model, Bone Marrow Transplant, 36, 907, 10.1038/sj.bmt.1705157 Takashima, 2011, The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells, J Exp Med, 208, 285, 10.1084/jem.20101559 Hanash, 2012, Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease, Immunity, 37, 339, 10.1016/j.immuni.2012.05.028 Ratanatharathorn, 1998, Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation, Blood, 92, 2303 Little, 2010, The coevolution of virulence: tolerance in perspective, PLoS Pathog, 6, e1001006, 10.1371/journal.ppat.1001006