Carolina Gutiérrez‐Repiso1,2, Carmen Hernández‐García1,2, José Manuel García‐Almeida1,2, Diego Bellido3, Gracia María Martín‐Núñez1,2, Lidia Sánchez‐Alcoholado1,2, Daniel Castellano‐Castillo1,2, Ignacio Sajoux4, Francisco J. Tinahones1,2, Isabel Moreno‐Indias1,2
1Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición CIBERobn Madrid 28029 Spain
2Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria Instituto de Investigación Biomédica de Málaga (IBIMA) Universidad de Málaga Málaga 29010 Spain
3División de Endocrinología Complejo Hospitalario Universitario de Ferrol Universidad de La Coruña Ferrol 15405 Spain
4Medical Department Pronokal Pronokal Group Barcelona 08009 Spain
Tóm tắt
ScopeLittle is known about the changes that a very‐low‐calorie ketogenic diet (VLCKD) produces in gut microbiota or the effect of synbiotics during the diet. The aim of this study is to evaluate changes in gut microbiota produced by a VLCKD and synbiotic supplementation.Methods and resultsA randomized, single‐blind, parallel‐design trial is conducted in 33 obese patients who follow a weight‐loss program (PnK‐Method) that include a VLCKD followed by a low‐calorie diet (LCD). Subjects are randomly allocated to three groups: one supplemented with synbiotics, a second group supplemented with a placebo during the VLCKD and synbiotics during the LCD phase, and a control group given a placebo.Although symbiotic administration do not produce an effect on microbial diversity, an increase in short‐chain fatty aciding producing bacteria and anti‐inflammatory mediator signals such as Odoribacter and Lachnospira is shown. The administration of Bifidobacterium animalis subsp. lactis and prebiotics fiber during the LCD is significantly associated with the percentage of weight loss and change in glucose, C‐reactive protein and lipopolysaccharide‐binding protein.ConclusionsVLCKD produces important changes in gut microbiota. The administration of synbiotics during VLCKD can improve weight loss through the amelioration of inflammation, which may be mediated by the gut microbiota.
