Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Collins, 2011, Scientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health, Anderson W, Dhansay MA, Phillips A, et al. Grand challenges in global mental health, Nature, 475, 27, 10.1038/475027a

Karr, 2011, Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan: a review, Nutr Neurosci, 14, 216, 10.1179/1476830511Y.0000000012

Féart, 2009, Adherence to a Mediterranean diet, cognitive decline, and risk of dementia, JAMA, 302, 638, 10.1001/jama.2009.1146

Valls-Pedret, 2015, Mediterranean diet and age-related cognitive decline: a randomized clinical trial, JAMA Intern Med, 175, 1094, 10.1001/jamainternmed.2015.1668

Luchtman, 2013, Cognitive enhancement by omega-3 fatty acids from child-hood to old age: findings from animal and clinical studies, Neuropharmacology, 64, 550, 10.1016/j.neuropharm.2012.07.019

Huang, 2010, Omega-3 fatty acids, cognitive decline, and Alzheimer’s disease: a critical review and evaluation of the literature, J Alzheimers Dis, 21, 673, 10.3233/JAD-2010-090934

Joffre, 2014, n-3 LCPUFA improves cognition: the young, the old and the sick, Prostaglandins Leukot Essent Fatty Acids, 91, 1, 10.1016/j.plefa.2014.05.001

Albanese, 2009, Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study, Am J Clin Nutr, 90, 392, 10.3945/ajcn.2009.27580

Barberger-Gateau, 2007, Dietary patterns and risk of dementia: the Three-City cohort study, Neurology, 69, 1921, 10.1212/01.wnl.0000278116.37320.52

Kalmijn, 1997, Dietary fat intake and the risk of incident dementia in the Rotterdam study, Ann Neurol, 42, 776, 10.1002/ana.410420514

Morris, 2003, Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease, Arch Neurol, 60, 940, 10.1001/archneur.60.7.940

Devore, 2009, Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk, Am J Clin Nutr, 90, 170, 10.3945/ajcn.2008.27037

Huang, 2005, Benefits of fatty fish on dementia risk are stronger for those without APOE ε4, Neurology, 65, 1409, 10.1212/01.wnl.0000183148.34197.2e

Lin, 2012, A meta-analytic review of polyunsaturated fatty acid compositions in dementia, J Clin Psychiatry, 73, 1245, 10.4088/JCP.11r07546

Mazereeuw, 2012, Effects of ω-3 fatty acids on cognitive performance: a meta-analysis, Neurobiol Aging, 33, 1482, 10.1016/j.neurobiolaging.2011.12.014

Sydenham, 2012, Omega 3 fatty acid for the prevention of cognitive decline and dementia, Cochrane Database Syst Rev, 6, CD005379

Wu, 2015, Omega-3 fatty acids intake and risks of dementia and Alzheimer’s disease: a meta-analysis, Neurosci Biobehav Rev, 48, 1, 10.1016/j.neubiorev.2014.11.008

Bishop, 2010, Neural mechanisms of ageing and cognitive decline, Nature, 464, 529, 10.1038/nature08983

Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, BMJ, 339, b2535, 10.1136/bmj.b2535

Wells, 2013

Zhang, 1998, What’s the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes, JAMA, 280, 1690, 10.1001/jama.280.19.1690

Orsini, 2006, Generalized least squares for trend estimation of summarized dose-response data, Stata J, 6, 40, 10.1177/1536867X0600600103

Orsini, 2012, Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software, Am J Epidemiol, 175, 66, 10.1093/aje/kwr265

Chen, 2003, Dietary intakes of fat and risk of Parkinson’s disease, Am J Epidemiol, 157, 1007, 10.1093/aje/kwg073

He, 2004, Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies, Circulation, 109, 2705, 10.1161/01.CIR.0000132503.19410.6B

Global Organization for EPA and DHA Omega-3s (GOED). Global recommendations for EPA and DHA intake [Internet]. [cited 2014 Apr 16]. GOED, Salt Lake City, UT, USA Available from: http://www.goedomega3.com/index.php/files/download/304

Jackson, 2010, Extending DerSimonian and Laird’s methodology to perform multivariate random effects meta-analyses, Stat Med, 29, 1282, 10.1002/sim.3602

Higgins, 2003, Measuring inconsistency in meta-analyses, BMJ, 327, 557, 10.1136/bmj.327.7414.557

González, 2010, The relationship between dietary lipids and cognitive performance in an elderly population, Int J Food Sci Nutr, 61, 217, 10.3109/09637480903348098

Kesse-Guyot, 2011, SU.VI.MAX 2 Research Group. Thirteen-year prospective study between fish consumption, long-chain n-3 fatty acids intakes and cognitive function, J Nutr Health Aging, 15, 115, 10.1007/s12603-011-0023-7

Nurk, 2007, Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study, Am J Clin Nutr, 86, 1470, 10.1093/ajcn/86.5.1470

Roberts, 2010, Vegetables, unsaturated fats, moderate alcohol intake, and mild cognitive impairment, Dement Geriatr Cogn Disord, 29, 413, 10.1159/000305099

Ammann, 2013, ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA, Neurology, 81, 1484, 10.1212/WNL.0b013e3182a9584c

Beydoun, 2008, n-3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study, Public Health Nutr, 11, 17, 10.1017/S1368980007000080

Cherubini, 2007, Low plasma N-3 fatty acids and dementia in older persons: the InCHIANTI study, J Gerontol A Biol Sci Med Sci, 62, 1120, 10.1093/gerona/62.10.1120

Okereke, 2012, Dietary fat types and 4-year cognitive change in community-dwelling older women, Ann Neurol, 72, 124, 10.1002/ana.23593

Solfrizzi, 1999, High monounsaturated fatty acids intake protects against age-related cognitive decline, Neurology, 52, 1563, 10.1212/WNL.52.8.1563

Velho, 2008, Dietary intake adequacy and cognitive function in free-living active elderly: a cross-sectional and short-term prospective study, Clin Nutr, 27, 77, 10.1016/j.clnu.2007.10.011

Wang, 2008, Nutritional biomarkers in Alzheimer’s disease: the association between carotenoids, n-3 fatty acids, and dementia severity, J Alzheimers Dis, 13, 31, 10.3233/JAD-2008-13103

Whalley, 2008, n-3 Fatty acid erythrocyte membrane content, APOE ε4, and cognitive variation: an observational follow-up study in late adulthood, Am J Clin Nutr, 87, 449, 10.1093/ajcn/87.2.449

Zhang, 2005, Dietary fat intake is associated with psychosocial and cognitive functioning of school-aged children in the United States, J Nutr, 135, 1967, 10.1093/jn/135.8.1967

Gao, 2011, Omega-3 polyunsaturated fatty acid supplements and cognitive decline: Singapore Longitudinal Aging Studies, J Nutr Health Aging, 15, 32, 10.1007/s12603-011-0010-z

Laurin, 2003, Omega-3 fatty acids and risk of cognitive impairment and dementia, J Alzheimers Dis, 5, 315, 10.3233/JAD-2003-5407

Beydoun, 2007, Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study, Am J Clin Nutr, 85, 1103, 10.1093/ajcn/85.4.1103

de Lau, 2005, Dietary fatty acids and the risk of Parkinson disease: the Rotterdam Study, Neurology, 64, 2040, 10.1212/01.WNL.0000166038.67153.9F

Engelhart, 2002, Diet and risk of dementia: does fat matter? The Rotterdam Study, Neurology, 59, 1915, 10.1212/01.WNL.0000038345.77753.46

Eskelinen, 2008, Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study, Int J Geriatr Psychiatry, 23, 741, 10.1002/gps.1969

Heude, 2003, Cognitive decline and fatty acid composition of erythrocyte membranes—the EVA Study, Am J Clin Nutr, 77, 803, 10.1093/ajcn/77.4.803

Kalmijn, 1997, Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men, Am J Epidemiol, 145, 33, 10.1093/oxfordjournals.aje.a009029

Kim, 2010, Erythrocyte α-linolenic acid is associated with the risk for mild dementia in Korean elderly, Nutr Res, 30, 756, 10.1016/j.nutres.2010.10.005

Kröger, 2009, Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging, Am J Clin Nutr, 90, 184, 10.3945/ajcn.2008.26987

Laitinen, 2006, Fat intake at midlife and risk of dementia and Alzheimer’s disease: a population-based study, Dement Geriatr Cogn Disord, 22, 99, 10.1159/000093478

Lopez, 2011, High dietary and plasma levels of the omega-3 fatty acid docosahexaenoic acid are associated with decreased dementia risk: the Rancho Bernardo Study, J Nutr Health Aging, 15, 25, 10.1007/s12603-011-0009-5

Miyake, 2010, Dietary fat intake and risk of Parkinson’s disease: a case-control study in Japan, J Neurol Sci, 288, 117, 10.1016/j.jns.2009.09.021

Roberts, 2010, Polyunsaturated fatty acids and reduced odds of MCI: the Mayo Clinic Study of Aging, J Alzheimers Dis, 21, 853, 10.3233/JAD-2010-091597

Samieri, 2008, Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk, Am J Clin Nutr, 88, 714, 10.1093/ajcn/88.3.714

Solfrizzi, 2006, Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging, Exp Gerontol, 41, 619, 10.1016/j.exger.2006.03.017

Schaefer, 2006, Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study, Arch Neurol, 63, 1545, 10.1001/archneur.63.11.1545

Jiao, 2014, Effect of n-3 PUFA supplementation on cognitive function throughout the life span from infancy to old age: a systematic review and meta-analysis of randomized controlled trials, Am J Clin Nutr, 100, 1422, 10.3945/ajcn.114.095315

Mohajeri, 2015, Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer-type dementia, Nutrition, 31, 261, 10.1016/j.nut.2014.06.016

Bateman, 2012, Clinical and biomarker changes in dominantly inherited Alzheimer’s disease, N Engl J Med, 367, 795, 10.1056/NEJMoa1202753

Bazan, 2011, Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer’s, and other neurodegenerative diseases, Annu Rev Nutr, 31, 321, 10.1146/annurev.nutr.012809.104635

Chan, 2013, Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990-2010: a systematic review and analysis, Lancet, 381, 2016, 10.1016/S0140-6736(13)60221-4

Quinn, 2010, Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial, JAMA, 304, 1903, 10.1001/jama.2010.1510

Bégin, 2010, What is the link between docosahexaenoic acid, cognitive impairment, and Alzheimer’s disease in the elderly?

Amboni, 2015, Resting-state functional connectivity associated with mild cognitive impairment in Parkinson’s disease, J Neurol, 262, 425, 10.1007/s00415-014-7591-5

Pedersen, 2013, Prognosis of mild cognitive impairment in early Parkinson disease: the Norwegian ParkWest study, JAMA Neurol, 70, 580, 10.1001/jamaneurol.2013.2110

Dysken, 2014, Effect of vitamin E and memantine on functional decline in Alzheimer disease. The TEAM-AD VA Cooperative Randomized Trial, JAMA, 311, 33, 10.1001/jama.2013.282834

Sano, 1997, A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. The Alzheimer’s Disease Cooperative Study, N Engl J Med, 336, 1216, 10.1056/NEJM199704243361704

Gumpricht, 2014, Can ω-3 fatty acids and tocotrienol-rich vitamin E reduce symptoms of neurodevelopmental disorders?, Nutrition, 30, 733, 10.1016/j.nut.2013.11.001

Petersen, 2005, Vitamin E and donepezil for the treatment of mild cognitive impairment, N Engl J Med, 352, 2379, 10.1056/NEJMoa050151

Kang, 2006, A randomized trial of vitamin E supplementation and cognitive function in women, Arch Intern Med, 166, 2462, 10.1001/archinte.166.22.2462

Barberger-Gateau, 2011, Dietary omega 3 polyunsaturated fatty acids and Alzheimer’s disease: interaction with apolipoprotein E genotype, Curr Alzheimer Res, 8, 479, 10.2174/156720511796391926

Deary, 2002, Cognitive change and the APOE ε4 allele, Nature, 418, 932, 10.1038/418932a

Raber, 2000, Apolipoprotein E and cognitive performance, Nature, 404, 352, 10.1038/35006165

Nguyen, 2014, Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid, Nature, 509, 503, 10.1038/nature13241

Greenland, 1992, Methods for trend estimation from summarized dose-response data, with applications to meta-analysis, Am J Epidemiol, 135, 1301, 10.1093/oxfordjournals.aje.a116237