Successful use of cyclosporine A in the treatment of refractory thrombotic thrombocytopenic purpura

British Journal of Haematology - Tập 100 Số 3 - Trang 597-599 - 1998
Hand1, Lawlor2, Yong2, Jeffrey Davis2
1Department of Pediatrics, University of British Columbia, British Columbia's Children's Hospital, Vancouver, Canada
2, University of British Columbia

Tóm tắt

Thrombotic thrombocytopenic purpura (TTP) is, in most cases, treatable with plasma exchange therapy (PLEX). Rarely, patients do not respond to PLEX or develop refractory disease despite an initial remission. In these cases, treatment options are limited and the response to established alternative therapies is often disappointing. We report the case of a paediatric patient with TTP who developed refractory disease after an initial response to PLEX. She was subsequently treated with cyclosporine A and showed an immediate and sustained response. CSA may be a safe and effective therapy for patients with refractory TTP and should be studied in randomized, prospective clinical trials.

Từ khóa


Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

British Journal of Haematology

Tập 100 Số 3

597-599

Thông tin tác giả