Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia

Blood - Tập 126 - Trang 1033-1040 - 2015
Stefan O. Ciurea1, Mei-Jie Zhang2,3, Andrea A. Bacigalupo4, Asad Bashey5, Frederick R. Appelbaum6, Omar S. Aljitawi7, Philippe Armand8, Joseph H. Antin8, Junfang Chen2, Steven M. Devine9, Daniel H. Fowler10, Leo Luznik11, Ryotaro Nakamura12, Paul V. O'Donnell6, Miguel-Angel Perales13, Sai Ravi Pingali1, David L. Porter14, Marcie R. Riches15, Olle T.H. Ringdén16, Vanderson Rocha17
1Department of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX;
2Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
3Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI
4Department of Hematology, IRCCS Azienda Ospedaliera Universitaria (AOU) San Martino—IST, Genoa, Italy;
5Department of Medicine, Northside Hospital, Atlanta, GA;
6Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
7Department of Medicine, University of Kansas Medical Center, Kansas City, KS
8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
9Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Arthur C. James Cancer Hospital, Columbus, OH;
10Experimental Transplantation and Immunobiology, Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD;
11Department of Medicine – Hematology, Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD;
12Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
13Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY;
14Hematology-Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA;
15Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;
16Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
17Churchill Hospital, Oxford, United Kingdom

Tóm tắt

Key Points Lower GVHD after haploidentical transplant with posttransplant cyclophosphamide compared with HLA-matched unrelated donor transplant. Comparable overall survival after haploidentical compared with matched unrelated donor transplant for AML.

Tài liệu tham khảo

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