CHEK2 mutations in primary glioblastomas

Y Ino JS Silver L Blazejewski R Nishikawa M Matsutani A Deimling Particlevon DN Louis (1999) ArticleTitleCommon regions of deletion on chromosome 22q12.3-q13.1 and 22q13.2 in human astrocytomas appear related to malignancy grade J Neuropathol Exp Neurol 58 881–885 Occurrence Handle10446812 K Hoang-Xuan P Merel F Vega J-P Hugot P Cornu J-Y Delattre M Poisson G Thomas O Delattre (1995) ArticleTitleAnalysis of the NF2 tumor-suppressor gene and of chromosome 22 deletions in gliomas Int J Cancer 60 478–481 Occurrence Handle7829260 S Matsuoka M Huang SJ Elledge (1998) ArticleTitleLinkage of ATM to cell cycle regulation by the Chk2 protein kinase Science 282 1893–1897 Occurrence Handle10.1126/science.282.5395.1893 Occurrence Handle9836640 S Matsuoka G Rotman A Ogawa Y Shiloh K Tamai SJ Elledge (2000) ArticleTitleAtaxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro Proc Natl Acad Sci USA 97 10389–10394 Occurrence Handle10.1073/pnas.190030497 Occurrence Handle10973490 NH Chehab A Malikzay M Appel TD Halazonetis (2000) ArticleTitleChk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53 Genes Dev 14 278–288 Occurrence Handle10673500 JS Lee KM Collins AL Brown CH Lee JH Chung (2000) ArticleTitlehCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response Nature 404 201–204 Occurrence Handle10.1038/35004614 Occurrence Handle10724175 J Falck N Mailand RG Syljuasen J Bartek J Lukas (2001) ArticleTitleThe ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis Nature 410 842–847 Occurrence Handle10.1038/35071124 Occurrence Handle11298456 DW Bell JM Varley TE Szydlo DH Kang DC Wahrer KE Shannon M Lubratovich SJ Verselis KJ Isselbacher JF Fraumeni JM Birch FP Li JE Garber DA Haber (1999) ArticleTitleHeterozygous germ line hCHK2 mutations in Li-fraumeni syndrome Science 286 2528–2531 Occurrence Handle10.1126/science.286.5449.2528 Occurrence Handle10617473 SB Lee SH Kim DW Bell DC Wahrer TA Schiripo MM Jorczak DC Sgroi JE Garber FP Li KE Nichols JM Varley AK Godwin KM Shannon E Harlow DA Haber (2001) ArticleTitleDestabilization of CHK2 by a missense mutation associated with Li-Fraumeni syndrome Cancer Res 61 8062–8067 Occurrence Handle11719428 P Vahteristo A Tamminen P Karvinen H Eerola C Eklund LA Aaltonen C Blomqvist K Aittomaki H Nevanlinna (2001) ArticleTitlep53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition Cancer Res 61 5718–5722 Occurrence Handle11479205 M Allinen P Huusko S Mantyniemi V Launonen R Winqvist (2001) ArticleTitleMutation analysis of the CHEK 2 gene in families with hereditary breast cancer Br J Cancer 85 209–212 Occurrence Handle10.1054/bjoc.2001.1858 Occurrence Handle11461078 H Meijers-Heijboer A Ouweland Particlevan den J Klijn M Wasielewski A Snoo Particlede R Oldenburg A Hollestelle M Houben E Crepin M Veghel-Plandsoen Particlevan F Elstrodt C Duijn Particlevan C Bartels C Meijers M Schutte L McGuffog D Thompson DF Easton N Sodha S Seal R Barfoot J Mangion J Chang-Claude D Eccels R Eeles DG Evans R Houlston V Murday S Narod T Peretz J Peto C Phealan HX Zhang C Szabo P Devilee D Goldgar PA Futreal KL Nathanson BL Weber N Rahman MR Sratton (2002) ArticleTitleLow-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations Nat Genet 31 55–59 Occurrence Handle10.1038/ng879 Occurrence Handle11967536 P Vahteristo J Bartkova H Eerola K Syrjakoski S Ojala O Kilpivaara A Tamminen J Kononen K Aittomaki P Heikkila K Holli C Blomqvist J Bartek OP Kallioniemi H Nevanlinna (2002) ArticleTitleA CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer Am J Hum Genet 71 432–438 Occurrence Handle10.1086/341943 Occurrence Handle12094328 M Schutte S Seal R Barfoot H Meijers-Heijboer M Wasielewski DG Evans D Eccles C Meijers F Lohman J Klijn A Ouweland Particlevan den Consortium TheBreastCancer Linkage PA Futreal KL Nathanson BL Weber DF Easton MR Stratton N Rahman (2003) ArticleTitleVariants inCHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility Am J Hum Genet 72 1023–1028 Occurrence Handle10.1086/373965 Occurrence Handle12610780 H Meijers-Heijboer J Wijnen H Vasen M Wasielewski A Wagner A Hollestelle F Elstrodt R VanDen Bos A De Snoo A Tjon G Fat C Brekelmans S Jagmohan P Franken P Verkuijlen A VanDen Ouweland P Chapman C Tops G Moslein J Burn H Lynch J Klijn R Fodde M Schutte (2003) ArticleTitleThe CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype Am J Hum Genet 72 1308–1314 Occurrence Handle10.1086/375121 Occurrence Handle12690581 InstitutionalAuthorNameCHEK2 Breast Cancer Case-Control Consortium (2004) ArticleTitleCHEK2* 1100delC and susceptibility to breast cancer: a collaborative analysis involving 10860 breast cancer cases and 9065 controls from 10 studies Am J Hum Genet 74 1175–1182 O Kilpivaara P Vahteristo J Falck K Syrjakoski H Eerola D Easton J Bartkova J Lukas P Heikkila K Aittomaki K Holli C Blomqvist OP Kallioniemi J Bartek H Nevalinna (2004) ArticleTitleCHEK2 variant I157T may be associated with increased breast cancer risk Int J Cancer 111 543–547 Occurrence Handle10.1002/ijc.20299 Occurrence Handle15239132 X Dong L Wang K Taniguchi X Wang JM Cunningham SK McDonnell C Qian AF Marks SL Slager BJ Peterson DI Smith JC Cheville ML Blute SJ Jacobsen DJ Schaid DJ Tindall SN Thibodeau W Liu (2003) ArticleTitleMutations in CHEK2 associated with prostate cancer risk Am J Hum Genet 72 270–280 Occurrence Handle10.1086/346094 Occurrence Handle12533788 EH Seppala T Ikonen N Mononen V Autio A Rokman MP Matikainen TLJ Tammela J Schleutker (2003) ArticleTitleCHEK2 variants associate with hereditary prostate cancer Br J Cancer 89 1966–1970 Occurrence Handle10.1038/sj.bjc.6601425 Occurrence Handle14612911 N Haruki H Saito Y Tatematsu H Konishi T Harano A Masuda H Osada Y Fujii T Takahashi (2000) ArticleTitleHistological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer Cancer Res 60 4689–4692 Occurrence Handle10987268 CW Miller T Ikezoe U Krug WK Hofmann S Tavor V Vegesna K Tsukasaki S Takeuchi HP Koeffler (2002) ArticleTitleMutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors Genes Chromosomes Cancer 33 17–21 Occurrence Handle10.1002/gcc.1207 Occurrence Handle11746983 A Reddy M Yuille A Sullivan C Repellin A Bell JA Tidy DJ Evans PJ Farrell B Gusterson M Gasco T Crook (2002) ArticleTitleAnalysis of CHK2 in vulval neoplasia Br J Cancer 86 756–760 Occurrence Handle10.1038/sj.bjc.6600131 Occurrence Handle11875739 Y Ino DC Wahrer DW Bell DA Haber DN Louis (2000) ArticleTitleMutation analysis of the hCHK2 gene in primary human malignant gliomas Neurogenetics 3 45–46 Occurrence Handle11085597 P Kleihues WK Cavenee (Eds) (2000) Astrocytic Tumors. Pathology and Genetics of Tumors of the Nervous System IARC Press Lyon PK Sallinen SL Sallinen PT Helen IS Rantala E Rautiainen HJ Helin H Kalimo HK Haapasalo (2000) ArticleTitleGrading of diffusely infiltrating astrocytomas by quantitative histopathology, cell proliferation and image cytometric DNA analysis Comparison of 133 IssueIDtumours in the context of the WHO 1979 and WHO 1993 grading schemes. Neuropathol Appl Neurobiol 26 319–331 H Haapasalo J Isola P Sallinen H Kalimo H Helin I Ranatala (1994) ArticleTitleAberrant p53 expression in astrocytic neoplasms of the brain: association with proliferation Am J Pathol 142 1347–1351 M Tanner D Gancberg A Di Leo D Larsimont G Rouas MJ Piccart J Isola (2000) ArticleTitleChromogenic in situ hybridization: a practical alternative for fluorescence in situ hybridization to detect HER-2/neu oncogene amplification in archival breast cancer samples Am J Pathol 157 1467–1472 Occurrence Handle11073807 X Wu SR Webster J Chen (2001) ArticleTitleCharacterization of tumor-associated Chk2 mutations J Biol Chem 276 2971–2974 Occurrence Handle10.1074/jbc.M009727200 Occurrence Handle11053450 J Li BL Williams LF Haire M Goldberg E Wilker D Durocher MB Yaffe SP Jackson SJ Smerdon (2002) ArticleTitleStructural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2 Mol Cell 9 1045–1054 Occurrence Handle10.1016/S1097-2765(02)00527-0 Occurrence Handle12049740 RA Oldenburg K Kroeze-Jansema J Kraan H Morreau JGM Klijn N Hoogerbrugge MJL Ligtenberg CJ Asperen Particlevan HFA Vasen C Meijers H Meijers-Hejboer TH Bock Particlede CJ Cornelisse P Devilee (2003) ArticleTitleThe CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families Cancer Res 63 8153–8157 Occurrence Handle14678969