Bone, Inflammation, and Inflammatory Bowel Disease

Current Osteoporosis Reports - Tập 9 - Trang 251-257 - 2011
Manasi Agrawal1, Shitij Arora2, Jianjun Li1, Rabin Rahmani1, Li Sun3, Adam F. Steinlauf4, Jeffrey I. Mechanick3, Mone Zaidi3
1Department of Gastroenterology, Maimonides Medical Center, Brooklyn, USA
2Department of Internal Medicine, Wyckoff Heights Medical Center, affiliate of Weill Cornell Medical College, Brooklyn, USA
3The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, USA
4Department of Gastroenterology, Mount Sinai School of Medicine, New York, USA

Tóm tắt

Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

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Current Osteoporosis Reports

Tập 9

251-257

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