The super elongation complex (SEC) and MLL in development and disease

Genes and Development - Tập 25 Số 7 - Trang 661-672 - 2011
Edward R. Smith1, Chengqi Lin2, Ali Shilatifard2
1Stowers Institute for Medical Research, Kansas City, Missouri, 64110, USA.
2Stowers Institute for Medical Research,

Tóm tắt

Transcriptional regulation at the level of elongation is vital for the control of gene expression and metazoan development. The mixed lineage leukemia (MLL) protein and its Drosophila homolog, Trithorax, which exist within COMPASS (complex of proteins associated with Set1)-like complexes, are master regulators of development. They are required for proper homeotic gene expression, in part through methylation of histone H3 on Lys 4. In humans, the MLL gene is involved in a large number of chromosomal translocations that create chimeric proteins, fusing the N terminus of MLL to several proteins that share little sequence similarity. Several frequent translocation partners of MLL were found recently to coexist in a super elongation complex (SEC) that includes known transcription elongation factors such as eleven-nineteen lysine-rich leukemia (ELL) and P-TEFb. Importantly, the SEC is required for HOX gene expression in leukemic cells, suggesting that chromosomal translocations involving MLL could lead to the overexpression of HOX and other genes through the involvement of the SEC. Here, we review the normal developmental roles of MLL and the SEC, and how MLL fusion proteins can mediate leukemogenesis.

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Tài liệu tham khảo

10.1016/S0960-9822(02)01399-4

10.1038/nature06145

10.1128/MCB.02366-05

10.1038/377557a0

10.1126/science.7660129

10.1387/ijdb.082664za

10.1038/onc.2008.443

10.1073/pnas.0705053104

10.1126/science.1173976

10.1182/blood-2009-06-229542

10.1074/jbc.C109.087981

10.1128/MCB.00769-07

10.1101/gad.1834709

2007, PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex, J Biol Chem, 282, 20385

10.1126/science.1162228

10.1038/nsmb1116

10.1016/j.cell.2007.08.019

10.1186/gb-2005-6-8-227

10.1016/j.cell.2005.04.031

10.1038/nsmb1128

10.1073/pnas.94.17.9006

10.1016/j.ydbio.2009.08.017

10.1073/pnas.152193699

10.1182/blood-2002-10-3221

10.1002/pro.404

10.1038/ng0596-105

10.1093/emboj/20.21.6104

10.1074/jbc.C400487200

10.1101/gad.1643208

1986, RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells, Mol Cell Biol, 6, 3984

10.1074/jbc.M809158200

10.1016/0092-8674(92)90603-A

10.1038/ng0596-109

10.1016/j.cell.2007.05.042

10.1016/j.molcel.2010.04.013

1996, Opening of an RNA polymerase II promoter occurs in two distinct steps and requires the basal transcription factors IIE and IIH, EMBO J, 15, 1666, 10.1002/j.1460-2075.1996.tb00512.x

10.1073/pnas.0707292104

10.1128/MCB.23.1.186-194.2003

10.1016/S1097-2765(04)00081-4

10.1007/BF00271751

10.1016/j.molcel.2005.06.027

10.1016/j.ydbio.2009.08.009

10.1038/330489a0

10.1101/gad.201901

10.1074/jbc.C200023200

10.1101/gad.6.11.2201

Kumar AR , Yao Q , Li Q , Sam TA , Kersey JH . 2010. t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL. Leuk Res doi: 10.1016/j.leukres.2010.08.011.

10.1038/nature06192

10.1016/0092-8674(89)90290-0

10.1128/MCB.01356-07

10.1074/jbc.M609809200

10.1016/j.cell.2007.09.046

10.1126/science.1149042

10.1074/jbc.M110.109801

10.1016/j.cell.2010.08.011

10.1016/j.molcel.2009.07.031

10.1016/j.molcel.2010.01.026

10.1101/gad.1544207

10.1091/mbc.E06-11-1060

1992, Control of formation of two distinct classes of RNA polymerase II elongation complexes, Mol Cell Biol, 12, 2078

10.1074/jbc.270.21.12335

10.1038/leu.2009.33

10.1074/jbc.M005175200

10.1073/pnas.231473398

10.1038/nrc2915

10.1038/ng.2007.21

10.1126/science.1181421

10.1016/j.molcel.2007.12.031

1998, A genetic screen to identify components of the sina signaling pathway in Drosophila eye development, Genetics, 148, 277, 10.1093/genetics/148.1.277

10.1128/MCB.01859-07

10.1016/S0092-8674(00)80903-4

10.1074/jbc.C800164200

10.1016/j.molcel.2006.06.014

2000, A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein, Genetics, 154, 695, 10.1093/genetics/154.2.695

10.1016/0968-0004(96)10045-1

10.1016/S0092-8674(88)91087-2

10.1146/annurev.genet.32.1.495

10.1038/nsmb1119

10.1038/nrm1981

10.1371/journal.pbio.1000013

10.1371/journal.pgen.1000805

1998, Factors regulating the transcriptional elongation activity of RNA polymerase II, FASEB J, 12, 1437, 10.1096/fasebj.12.14.1437

10.1146/annurev.biochem.75.103004.142422

10.1016/j.ceb.2008.03.019

10.1126/science.271.5257.1873

10.1146/annurev.biochem.72.121801.161551

10.1101/gad.1235904

10.1128/MCB.01504-07

10.1073/pnas.0804379105

10.1016/j.molcel.2010.04.012

10.1074/jbc.M806900200

10.1038/nsmb1131

2001, A screen for modifiers of decapentaplegic mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt's Lymphoma family of transcription factors in Drosophila melanogaster, Genetics, 157, 717, 10.1093/genetics/157.2.717

10.1038/nsmb.1397

10.1101/gad.1449406

2001, Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian, Development, 128, 801, 10.1242/dev.128.5.801

10.1101/gad.1516207

10.1073/pnas.0507425103

10.1016/j.ccr.2009.12.034

10.1073/pnas.91.25.12110

10.1016/0092-8674(92)90602-9

10.1016/j.jmb.2006.04.050

10.1038/nsmb0709-678

10.1016/j.ydbio.2006.10.027

10.1016/j.cell.2007.08.016

10.1101/gad.12.3.343

10.1074/jbc.M806936200

10.1128/MCB.00924-09

10.1074/jbc.M109.046250

10.1016/j.cell.2009.06.049

1984, Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae, Genetics, 107, 179, 10.1093/genetics/107.2.179

2001, Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth, Development, 128, 791, 10.1242/dev.128.5.791

10.1128/MCB.00976-08

10.1016/j.cell.2005.03.036

10.1016/S0092-8674(00)80713-8

10.1074/jbc.274.50.35668

10.1016/j.molcel.2005.06.029

10.3109/10409238.2010.512001

10.1038/emboj.2008.249

10.1016/j.ccr.2008.05.003

10.1182/blood-2002-04-1015

10.1128/MCB.24.13.5639-5649.2004

10.1038/378505a0

10.1038/ng.2007.26

10.1128/MCB.00324-10

10.1128/MMBR.00011-06

10.1128/MCB.26.7.2728-2735.2006

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Genes and Development

Tập 25 Số 7

661-672

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