Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene

Springer Science and Business Media LLC - Tập 7 - Trang 673-676 - 1996
S. Savary1, F. Denizot2, M. -F. Luciani1, M. -G. Mattei3, G. Chimini1
1Centre d’Immunologie INSERM-CNRS de Marseille Luminy, Parc Scientifique de Luminy, Marseille Cedex 9, France
2Centre de Séquençage, LCB-CNRS, Joseph Aiguier, France
3U406, Hôpital d’Enfants de la Timone, Centre de Génétique Médicale, Marseille Cedex 5, France

Tóm tắt

Pigmentation of Drosophila eyes requires the concerted action of several genes, most of which have been cloned and characterized. Three of them, white, brown, and scarlet, have been directly implicated in the import of pigment precursors into the cells. These three genes encode similar proteins, belonging to the evolutionary conserved family of ATP Binding Cassette transporters. The identification of a novel mouse gene, ABC8, closely related to white is reported here, together with an analysis of its expression profile and its comparative mapping in mouse and human genome.

Tài liệu tham khảo

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