Lo EH, Dalkara T, Moskowitz MA: Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 2003, 4: 399-415. 10.1038/nrn1106.
Donnan GA, Fisher M, Macleod M, Davis SM: Stroke. Lancet. 2008, 371: 1612-1623. 10.1016/S0140-6736(08)60694-7.
American Heart Association: Heart Disease and Stroke Statistics - 2005 Update. 2005, Dallas, Texas: American Heart Association
Muir KW, Tyrrell P, Sattar N, Warburton E: Inflammation and ischaemic stroke. Curr Opin Neurol. 2007, 20: 334-342. 10.1097/WCO.0b013e32813ba151.
Dirnagl U, Iadecola C, Moskowitz MA: Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999, 22: 391-397. 10.1016/S0166-2236(99)01401-0.
Furlan AJ, Katzan IL, Caplan LR: Thrombolytic therapy in acute ischemic stroke. Curr Treat Options Cardiovasc Med. 2003, 5: 171-180. 10.1007/s11936-003-0001-4.
O'Collins VE, Macleod MR, Donnan GA, Horky LL, Worp van der BH, Howells DW: 1,026 experimental treatments in acute stroke. Ann Neurol. 2006, 59: 467-477. 10.1002/ana.20741.
De la Ossa NP, Davalos A: Neuroprotection in cerebral infarction: the opportunity of new studies. Cerebrovasc Dis. 2007, 24: 153-156. 10.1159/000107391.
Hossman K: Thresholds of ischemic injury. Cerebrovascular Disease: Pathophysiology Diagnosis and Management. Edited by: Ginsberg MD, Bogousslavsky J. 1988, Malden, UK: Blackwell Science, 193-204.
Hossmann KA: Periinfarct depolarizations. Cerebrovasc Brain Metab Rev. 1996, 8: 195-208.
Singhal AB: Oxygen therapy in stroke: past, present, and future. Int J Stroke. 2006, 1: 191-200. 10.1111/j.1747-4949.2006.00058.x.
Singhal AB, Benner T, Roccatagliata L, Koroshetz WJ, Schaefer PW, Lo EH, Buonanno FS, Gonzalez RG, Sorensen AG: A Pilot Study of Normobaric Oxygen Therapy in Acute Ischemic Stroke. Stroke. 2005, 36: 797-802. 10.1161/01.STR.0000158914.66827.2e.
Coyle JT, Puttfarcken P: Oxidative stress, glutamate, and neurodegenerative disorders. Science. 1993, 262: 689-695. 10.1126/science.7901908.
Cuzzocrea S, Riley DP, Caputi AP, Salvemini D: Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev. 2001, 53: 135-159.
Yamagata K, Ichinose S, Miyashita A, Tagami M: Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat. Neuroscience. 2008, 153: 428-435. 10.1016/j.neuroscience.2008.02.028.
Ozkan OV, Yuzbasioglu MF, Ciralik H, Kurutas EB, Yonden Z, Aydin M, Bulbuloglu E, Semerci E, Goksu M, Atli Y, Bakan V, Duran N: Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats. Tohoku J Exp Med. 2009, 218: 251-258. 10.1620/tjem.218.251.
Nguyen T, Nioi P, Pickett CB: The nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 2009, 284: 13291-13295. 10.1074/jbc.R900010200.
Johnson JA, Johnson DA, Kraft AD, Calkins MJ, Jakel RJ: The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. Ann N Y Acad Sci. 2008, 1147: 61-69.
Shih AY, Li P, Murphy TH: A small molecule inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci. 2005, 25: 10321-10335. 10.1523/JNEUROSCI.4014-05.2005.
Wong Ch, Crack PJ: Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injur. Curr Med Chem. 2008, 15: 1-14. 10.2174/092986708783330665.
Yilmaz G, Granger DN: Cell adhesion molecules and ischemic stroke. Neurol Res. 2008, 30: 783-93. 10.1179/174313208X341085.
D'Ambrosio AL, Pinsky DJ, Connolly ES: The role of the complement cascade in ischemia/reperfusion injury: implications for neuroprotection. Mol Med. 2001, 7: 367-382.
Arumugam TV, Woodruff TM, Lathia JD, Selvaraj PK, Mattson MP, Taylor SM: Neuroprotection in stroke by complement inhibition and immunoglobulin therapy. Neuroscience. 2009, 158: 1074-1089. 10.1016/j.neuroscience.2008.07.015.
Ekdahl CT, Kokaia Z, Lindvall O: Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience. 2009, 158: 1021-1029. 10.1016/j.neuroscience.2008.06.052.
Lucas SM, Rothwell NJ, Gibson RM: The role of inflammation in CNS injury and disease. Br J Pharmacol. 2006, 147 (Suppl 1): S232-40. 10.1038/sj.bjp.0706400.
Swanson RA, Ying W, Kauppinen TM: Astrocyte influences on ischemic neuronal death. Curr Mol Med. 2004, 4: 193-205. 10.2174/1566524043479185.
Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A: Pivotal role of cerebral interleukin-17-producing γδT cells in the delayed phase of ischemic brain injury. Nat Med. 2009, 15: 946-950. 10.1038/nm.1999.
Barone FC, Feuerstein GZ: Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab. 1999, 19: 819-34. 10.1097/00004647-199908000-00001.
Ferrarese C, Mascarucci P, Zoia C, Cavarretta R, Frigo M, Begni B, Sarinella F, Frattola L, De Simoni MG: Increased cytokine release from peripheral blood cells after acute stroke. J Cereb Blood Flow Metab. 1999, 19: 1004-9. 10.1097/00004647-199909000-00008.
Zhu Y, Yang GY, Ahlemeyer B, Pang L, Che XM, Culmsee C, Klumpp S, Krieglstein J: Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage. J Neurosci. 2002, 22: 3898-909.
Spera PA, Ellison JA, Feuerstein GZ, Barone FC: IL-10 reduces rat brain injury following focal stroke. Neurosci Lett. 1998, 251: 189-92. 10.1016/S0304-3940(98)00537-0.
Caso JR, Moro MA, Lorenzo P, Lizasoain I, Leza JC: Involvement of IL-1β in acute stress induced worsening of cerebral ischemia in rats. Eur Neuropsychopharmacol. 2007, 17: 600-607. 10.1016/j.euroneuro.2007.02.009.
Yamasaki Y, Matsuura N, Shozuhara H, Onodera H, Itoyama Y, Kogure K: Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke. 1995, 26: 676-680.
Boutin H, LeFeuvre RA, Horai R, Asano M, Iwakura Y, Rothwell NJ: Role of IL-1α and IL-1β in ischemic brain damage. J Neurosci. 2001, 21: 5528-5534.
Clark WM, Rinker LG, Lessov NS, Hazel K, Eckenstein F: Time course of IL-6 expression in experimental CNS ischemia. Neurol Res. 1999, 21: 287-292.
Acalovschi D, Wiest T, Hartmann M, Farahmi M, Mansmann U, Auffarth GU, Grau AJ, Green FR, Grond-Ginsbach C, Schwaninger M: Multiple levels of regulation of the interleukin-6 system in stroke. Stroke. 2003, 34: 1864-1870. 10.1161/01.STR.0000079815.38626.44.
Vila N, Castillo J, Davalos A, Chammoro A: Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke. 2001, 31: 2325-2329.
Clark WM, Rinker LG, Lessov NS, Hazel K, Hill JK, Stenzel-Poore M, Eckenstein F: Lack of interleukin-6 expression is not protective against focal central system ischemia. Stroke. 2001, 31: 1715-1720.
Chen WY, Chang MS: IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. J Immunol. 2009, 182: 5000-5012.
Gueorguieva I, Clark SR, McMahon CJ, Scarth S, Rothwell NJ, Tyrrell PJ, Hopkins SJ, Rowland M: Pharmacokinetic modeling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid hemorrhage. Br J Clin Pharmacol. 2008, 65: 317-325. 10.1111/j.1365-2125.2007.03026.x.
Tarkowski E, Rosengren L, Blomstrand C, Wikkelsö C, Jensen C, Ekholm S, Tarkowski A: Intrathecal release of pro- and anti-inflammatory cytokines during stroke. Clin Exp Immunol. 1997, 110: 492-499. 10.1046/j.1365-2249.1997.4621483.x.
Kim JS, Gautam SC, Chopp M, Zaloga C, Jones ML, Ward PA, Welch KMA: Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat. J Neuroimmunol. 1995, 56: 127-134. 10.1016/0165-5728(94)00138-E.
Soriano S, Amaravadi L, Wang Y, Zhou H, Yu G, Tonra J, Fairchild-Huntress V, Fang Q, Dunmore J, Huszar D: Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury. J Neuroimmunol. 2002, 125: 59-65. 10.1016/S0165-5728(02)00033-4.
Hughes PM, Allegrini PR, Rudin M, Perry VH, Mir AK, Wiessner C: Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model. J Cereb Blood Flow Metab. 2002, 22: 308-17. 10.1097/00004647-200203000-00008.
Kumai Y, Ooboshi H, Takada J, Kamouchi M, Kitazono T, Egashira K, Ibayashi S, Iida M: Anti-monocyte chemoattractant protein-1 gene therapy protects against focal brain ischemia in hypertensive rats. J Cereb Blood Flow Metab. 2004, 24: 1359-1368. 10.1097/00004647-200412000-00005.
Dimitrijevic OB, Stamatovic SM, Keep RF, Andjelkovic AV: Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice. Stroke. 2007, 38: 1345-1353. 10.1161/01.STR.0000259709.16654.8f.
Zhang R, Chopp M, Zhang Z, Jiang N, Powers C: The expression of P- and E-selectins in three models of middle cerebral artery occlusion. Brain Res. 1998, 785: 207-214. 10.1016/S0006-8993(97)01343-7.
Lindsberg PJ, Carpén O, Paetau A, Karjalainen-Lindsberg ML, Kaste M: Endothelial ICAM-1 Expression Associated With Inflammatory Cell Response in Human Ischemic Stroke. Circulation. 1996, 94: 939-945.
Rallidis LS, Zolindaki MG, Vikelis M, Kaliva K, Papadopoulos C, Kremastinos DT: Elevated soluble intercellular adhesion molecule-1 levels are associated with poor short-term prognosis in middle-aged patients with acute ischaemic stroke. Int J Cardiol. 2009, 132: 216-220. 10.1016/j.ijcard.2007.11.031.
Zhang RL, Chopp M, Li Y: Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat. Neurology. 1994, 44: 1747-1751.
Goussev AV, Zhang Z, Anderson DC, Chopp M: P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat. J Neurosci. 1998, 161: 16-22.
Montaner J, Alvarez-Sabin J, Molina C, Angles A, Abilleira S, Arenillas J, Gonzalez MA, Monasterio J: Matrix metalloproteinase expression after human cardioembolic stroke: temporal profile and relation to neurological impairment. Stroke. 2001, 32: 1759-66. 10.1161/hs1201.99512.
Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH: Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001, 21: 7724-7732.
Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH: Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke. 2009, 40: 2836-2842. 10.1161/STROKEAHA.109.554824.
Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang X, Lo EH: Role of metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006, 12: 441-445. 10.1038/nm1387.
Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U: Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci. 2005, 6: 775-786. 10.1038/nrn1765.
Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R: Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 2009, 15: 192-199. 10.1038/nm.1927.
O'Garra A, Vieira P: Regulatory T cells and mechanisms of immune system control. Nat Med. 2004, 10: 801-805. 10.1038/nm0804-801.
Sharma MD, Baban B, Chandler P, Hou DY, Singh N, Yagita H, Azuma M, Blazar BR, Mellor AL, Munn DH: Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest. 2007, 117: 2570-2582. 10.1172/JCI31911.
O'Connor JC, Andre C, Wang Y, Lawson MA, Szegedi SS, Lestage J, Castanon N, Kelley KW, Dantzer R: Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J Neurosci. 2009, 29: 4200-9. 10.1523/JNEUROSCI.5032-08.2009.
Brown CE, Wong C, Murphy TH: Rapid morphologic plasticity of peri-infarct dendritic spines after focal ischemic stroke. Stroke. 2008, 39: 1286-1291. 10.1161/STROKEAHA.107.498238.
Calautti C, Baron J-C: Functional Neuroimaging Studies of Motor Recovery After Stroke in Adults: A Review. Stroke. 2003, 34: 1553-1566. 10.1161/01.STR.0000071761.36075.A6.
Eliassen JC, Boespflug EL, Lamy M, Allendorfer J, Chu WJ, Szaflarski JP: Brain-mapping techniques for evaluating poststroke recovery and rehabilitation: a review. Top Stroke Rehabil. 2008, 15: 427-450. 10.1310/tsr1505-427.
Macas J, Nern C, Plate KH, Momma S: Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain. J Neurosci. 2006, 26: 13114-13119. 10.1523/JNEUROSCI.4667-06.2006.
Minger SL, Ekonomou A, Carta EM, Chinoy A, Perry RH, Ballard CG: Endogenous neurogenesis in the human brain following cerebral infarction. Regen Med. 2007, 2: 69-74. 10.2217/17460751.2.1.69.
Yamashita T, Ninomiya M, Hernandez Acosta P, Garcia-Verdugo JM, Sunabori T, Sakaguchi M, Adachi K, Kojima T, Hirota Y, Kawase T, Araki N, Abe K, Okano H, Sawamoto K: Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J Neurosci. 2006, 26: 6627-6636. 10.1523/JNEUROSCI.0149-06.2006.
Emsley HC, Smith CJ, Georgiou RF, Vail A, Hopkins SJ, Rothwell NJ, Tyrrell PJ: Acute Stroke Investigators: A randomized phase II study of interleukin-1 receptor antagonist in acute stroke patients. J Neurol Neurosurg Psychiatry. 2005, 76: 1366-1372. 10.1136/jnnp.2004.054882.
Enlimomab Acute Stroke Trial Investigators: Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial. Neurology. 2001, 57: 1428-1434.
Bath PM, Iddenden R, Bath FJ, Orgogozo JM, Tirilazad International Steering Committee: Tirilazad for acute ischaemic stroke. The Cochrane Database Syst Rev. 2001, 4: CD002087-
Krams M, Lees KR, Hacke W, Grieve AP, Orgogozo JM, Ford GA, ASTIN Study Investigators: Acute stroke therapy by inhibition of neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischaemic stroke. Stroke. 2003, 34: 2543-2548. 10.1161/01.STR.0000092527.33910.89.
Lyden PD, Shuaib A, Lees KR, Davalos A, Davis SM, Diener HC, Grotta JC, Ashwood TJ, Hardemark HG, Svensson HH, Rodichok L, Wasiewski WW, Ahlberg G, CHANT Trial Investigators: Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT trial. Stroke. 2007, 38: 2262-2269. 10.1161/STROKEAHA.106.472746.
Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener HC, Ashwood T, Wasiewski WW, Emeribe U, SAINT II Trials Investigators: NXY-059 for treatment of acute ischemic stroke. N Engl J Med. 2007, 357: 562-571. 10.1056/NEJMoa070240.
van Breda EJ, Worp van der HB, van Gemert HM, Algra A, Kappelle LJ, van Gijn J, Koudstaal PJ, Dippel DW, PAIS investigators: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN 74418480]. BMC Cardiovasc Disord. 2005, 5: 24-10.1186/1471-2261-5-24.
Lampl Y, Boaz M, Gilad R, Lorberboym M, Dabby R, Rapoport A, Anca-Hershkowitz M, Sadeh M: Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology. 2007, 69: 1404-10. 10.1212/01.wnl.0000277487.04281.db.
Liu X, Xia J, Wang L, Song Y, Yang J, Yan Y, Ren H, Zhao G: Efficacy and safety of ginsenoside-Rd for acute ischaemic stroke a randomized, double-blind, placebo-controlled, phase II multicenter trial. Eur J Neurol. 2009, 5: 569-75. 10.1111/j.1468-1331.2009.02534.x.
The Edaravone Acute Brain Infarction Study Group: Effect of a novel free radical scavenger, Edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis. 2003, 15: 222-229. 10.1159/000069318.
Pettigrew LC, Kasner SE, Albers GW, Gorman M, Grotta JC, Sherman DG, Funakoshi Y, Ishibashi H, Arundic Acid (ONO-2506) Stroke Study Group: Safety and tolerability of arundic acid in acute ischemic stroke. J Neurol Sci. 2006, 251: 50-6. 10.1016/j.jns.2006.09.001.
Shah IM, Macrae M, Di Napoli M: Neuroinflammation and neuroprotective strategies in acute ischaemic stroke - from bench to bedside. Curr Mol Med. 2009, 9: 336-354. 10.2174/156652409787847236.