Biosynthesis of Plant Isoprenoids: Perspectives for Microbial Engineering

Annual Review of Plant Biology - Tập 60 Số 1 - Trang 335-355 - 2009
James Kirby1, Jay D. Keasling2,3,4,5
1California Institute of Quantitative Biomedical Research, University of California, Berkeley, California 94720, USA.
2California Institute of Quantitative Biomedical Research, University of California, Berkeley, California 94720;
3Departments of Chemical Engineering and Bioengineering, University of California, Berkeley, California 94720;
4Joint BioEnergy Institute, Emeryville, California 94608
5Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720

Tóm tắt

Isoprenoids are a large and highly diverse group of natural products with many functions in plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl diphosphate precursors through the action of terpene synthases and terpene-modifying enzymes such as cytochrome P450 monooxygenases. Many isoprenoids have important applications in areas such as human health and nutrition, and much effort has been directed toward their production in microbial hosts. However, many hurdles must be overcome in the elucidation and functional microbial expression of the genes responsible for biosynthesis of an isoprenoid of interest. Here, we review investigations into isoprenoid function and gene discovery in plants as well as the latest advances in isoprenoid pathway engineering in both plant and microbial hosts.

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Annual Review of Plant Biology

Tập 60 Số 1

335-355

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