Self-medication of migraine and tension-type headache: summary of the evidence-based recommendations of the Deutsche Migräne und Kopfschmerzgesellschaft (DMKG), the Deutsche Gesellschaft für Neurologie (DGN), the Österreichische Kopfschmerzgesellschaft (ÖKSG) and the Schweizerische Kopfwehgesellschaft (SKG)
Tóm tắt
The current evidence-based guideline on self-medication in migraine and tension-type headache of the German, Austrian and Swiss headache societies and the German Society of Neurology is addressed to physicians engaged in primary care as well as pharmacists and patients. The guideline is especially concerned with the description of the methodology used, the selection process of the literature used and which evidence the recommendations are based upon. The following recommendations about self-medication in migraine attacks can be made: The efficacy of the fixed-dose combination of acetaminophen, acetylsalicylic acid and caffeine and the monotherapies with ibuprofen or naratriptan or acetaminophen or phenazone are scientifically proven and recommended as first-line therapy. None of the substances used in self-medication in migraine prophylaxis can be seen as effective. Concerning the self-medication in tension-type headache, the following therapies can be recommended as first-line therapy: the fixed-dose combination of acetaminophen, acetylsalicylic acid and caffeine as well as the fixed combination of acetaminophen and caffeine as well as the monotherapies with ibuprofen or acetylsalicylic acid or diclofenac. The four scientific societies hope that this guideline will help to improve the treatment of headaches which largely is initiated by the patients themselves without any consultation with their physicians.
Tài liệu tham khảo
Haag G, Evers S, May A, Neu IS, Vivell W, Ziegler A (2004) Selbstmedikation bei Migräne und Kopfschmerz vom Spannungstyp. Evidenzbasierte Empfehlungen der Deutschen Migräne- und Kopfschmerzgesellschaft (DMKG) [Self medication in migraine and tension-type headache—evidence-based treatment recommendations of the German Migraine and Headache Society]. Nervenheilkunde 23:415–430
Headache Classification Subcommittee of the International Headache Society (2004) The International Classification of Headache Disorders, 2nd edition (ICHD-II). Cephalalgia 24:S9–S160
Bellomo R, Bagshaw SM (2006) Evidence-based medicine: classifying the evidence from clinical trials—the need to consider other dimensions. Critical Care 10:232. doi:10.1186/cc5045, 17029653
Chou R (2008) Using evidence in pain practice. Pain Med 9:518–541, 18346062
Grimshaw J, Eccles M, Russell I (1995) Developing clinically valid practice guidelines. J Eval Clin Pract 1:37–48, 9238556, 1:STN:280:DyaK2szotFahtg%3D%3D
Lundh A, Gøtzsche PC (2008) Recommendations by cochrane review groups for assessment of the risk of bias in studies. BMC Med Res Methodol 8:22. doi:10.1186/1471-2288-8-22, 18426565
Sackett DL, Straus SE, Richardson WS, Rosenberg W, Haynes RB (2000) Evidence-based medicine—how to practice and teach EBM. Churchill Livingstone, Edinburgh
Thomas J, Harden A (2008) Methods for the thematic synthesis of qualitative research in systematic reviews. BMC Med Res Methodol 8:45. doi:10.1186/1471-2288-8-45, 18616818
McDonald S, Antes G, Galandi D, Gøtzsche P, Hammarquist C, Haugh M, Jensen KL, Kleijnen J, Loep M, Pistotti V, Rüther A (2002) The contribution of handsearching European general health care journals to the Cochrane Controlled Trials Register. Eval Health Prof 25:65–75, 11868446
Bickley SR, Harrison JE (2003) How to … find the evidence. J Orthodontics 30:72–78, 1:STN:280:DC%2BD3s7jtVansQ%3D%3D
Shekelle PG, Morton SC, Suttorp MJ, Buscemi N, Friesen C (2005) Challenges in systematic reviews of complementary and alternative medicine topics. Ann Intern Med 142:1042–1047, 15968028
Berger VW, Christophi CA (2003) Randomization technique, allocation concealment, masking, and susceptibility of trials to selection bias. J Mod Appl Stat Methods 2:80–86
European Agency for the Evaluation of Medicinal Products (EMEA) (1998) ICH Topic E 9 Statistical Principles for Clinical Trials. Step 5. Note for guidance on statistical principles for clinical trials. CPMP/ICH/363/96, Sep 1998
Juhl RP (1998) Prescription to over-the-counter switch: a regulatory perspective. Clin Therap 20(Suppl C):C111–C117
Berger VW, Weinstein S (2004) Ensuring the comparability of comparison groups: is randomization enough? Control Clin Trials 25:515–524, 15465620
Delgado-Rodriguez M, Llorca J (2004) Bias. J Epidemiol Community Health 58:635–641, 15252064
Hamunen K, Kalso E (2005) A systematic review of trial methodology, using the placebo groups of randomized controlled trials in paediatric postoperative pain. Pain 116:146–158, 15936888
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12, 8721797, 1:STN:280:DyaK28zgvVCmug%3D%3D
Kendall JM (2003) Designing a research project: randomised controlled trials and their principles. Emerg Med J 20:164–168, 12642531, 1:STN:280:DC%2BD3s7isl2nsw%3D%3D
Reeves BC (2003) Principles of research: limitations of non-randomized studies. Surgery 21:129–133
Schulz KF, Grimes DA (2005) Multiplicity in randomised trials I: endpoints and treatments. Lancet 365:1591–1595, 15866314
Macedo A, Farré M, Baños JE (2006) A meta-analysis of the placebo response in acute migraine and how this response may be influenced by some of the characteristics of clinical trials. Eur J Clin Pharmacol 62:161–172, 16402240
Deeks JJ, Altman DG (1998) Inadequate reporting of controlled trials as short reports. Lancet 352:1908, 9863796, 1:STN:280:DyaK1M%2FnvFGjsg%3D%3D
Rosmarakis ES, Soteriades ES, Vergidis PI, Kasiakou SK, Falagas ME (2005) From conference abstract to full paper: differences between data presented in conferences and journals. FASEB J 19:673–680, 15857882, 1:CAS:528:DC%2BD2MXktVKmu74%3D
Evans M, Pollock A (1985) A score system for evaluating random control clinical trials of prophylaxis of abdominal surgical wound infection. Br J Surg 72:256–260, 3986472, 1:STN:280:DyaL2M7nsFOksw%3D%3D
Snow V, Weiss K, Wall EM, Mottur-Pilson C (2002) Pharmacologic management of acute attacks of migraine and prevention of migraine headache. Ann Intern Med 137:840–849, 12435222, 1:CAS:528:DC%2BD38Xptlajur0%3D
Silberstein SD, Rosenberg J (2000) Multispeciality consensus on diagnosis and treatment of headache. Neurology 54:1553, 10762491, 1:STN:280:DC%2BD3c3islymtw%3D%3D
Berman NG, Parker RA (2002) Meta-analysis: Neither quick nor easy. BMC Medical Res Methodol 2:(10)1–9
Kjaergard LL, Villumsen J, Gluud C (2001) Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 135:982–989, 11730399, 1:STN:280:DC%2BD3MnovVygsg%3D%3D
European Agency for the Evaluation of Medicinal Products (EMEA): points to consider on switching between superiority and non-inferiority. London, CPMP/EWP/482/99, July 2000
European Medicines Agency (EMEA): guideline on the choice of the non-inferiority margin. London, EMEA/CPMP/EWP/2158/99, July 2005
Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B, Lipton RB (2009) Headache classification by history has only limited predictive value for headache episodes treated in controlled trials with OTC analgesics. Cephalalgia 29:188–193, 18823361
Bigal ME, Bordini CA, Speciali JG (2002) Efficacy of three drugs in the treatment of migrainous aura: a randomized placebo-controlled study. Arqu Neuro-psiquiatr 60(2-B):406–409
Bomhof M, Paz J, Legg N, Allen C, Vandormael K, Patel K (1999) Comparison of rizatriptan 10 mg vs. naratriptan 2.5 mg in migraine. Eur Neurol 42:173–179, 10529545, 1:CAS:528:DyaK1MXnvVGgs7k%3D
Danesch U, Rittinghausen R (2003) Safety of a patented special butterbur root extract for migraine prevention. Headache 43:76–78, 12864764
Diener HC, Rahlfs VW, Danesch U (2004) The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol 51:89–97, 14752215, 1:STN:280:DC%2BD2c7htFWmug%3D%3D
Diener HC, Bussone G, de Liano H, Eikermann A, Englert R, Floeter T, Gallai V, Göbel H, Hartung E, Jimenez MD, Lange R, Manzoni GC, Mueller-Schwefe G, Nappi G, Pinessi L, Prat J, Puca FM, Titus F, Voelker M (2004) EMSASI Study Group. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks. Cephalalgia 24:947–954, 15482357, 1:STN:280:DC%2BD2crht1Ciuw%3D%3D
Diener HC, Eikermann A, Gessner U, Göbel H, Haag G, Lange R, May A, Müller-Schwefe G, Voelker M (2004) Efficacy of 1,000 mg effervescent acetylsalicylic acid and sumatriptan in treating associated migraine symptoms. Eur Neurol 52:50–56, 15240983, 1:CAS:528:DC%2BD2cXmsV2itrw%3D
Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B (2005) The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 25:776–787, 16162254, 1:STN:280:DC%2BD2MvptFGqtg%3D%3D
Garcia-Ramos G, MacGregor EA, Hilliard B, Bordini CA, Leston J, Hettiarachchi J (2003) Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. Cephalalgia 23:869–876, 14616928, 1:STN:280:DC%2BD3srlsFegug%3D%3D
Göbel H, Heinze A, Dworschak M, Heinze-Kuhn K, Stolze H (2004) Oleum menthae piperitae in der Akuttherapie von Migräne und Kopfschmerz vom Spannungstyp. Z Phytother 25:129–139
Göbel H, Heinze A, Niederberger U, Witt T, Zumbroich V (2004) Efficacy of phenazone in the treatment of acute migraine attacks: a double-blind, placebo-controlled, randomized study. Cephalalgia 24:888–893, 15377321
Goldstein J, Silberstein SD, Saper JR, Elkind AH, Smith TR, Gallagher RM, Battikha JP, Hoffman H, Baggish J (2005) Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. Headache 45:973–982, 16109110
Goldstein J, Silberstein SD, Saper JR, Ryan RE, Lipton RB (2006) Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 46:444–453, 16618262
Grigorova NA, Leshchenko OK (2003) Current aspects of the treatment of migraine. Likarska Sprava 5–6:80–85
Haas DC, Sheehe PR (2004) Dextroamphetamine pilot crossover trials and n of 1 trials in patients with chronic tension-type and migraine headache. Headache 44:1029–1037, 15546268
Havanka H, Dahlöf C, Pop PH, Diener HC, Winter P, Whitehouse H, Hassani H (2000) Efficacy of naratriptan tablets in the acute treatment of migraine: a dose-ranging study. Naratriptan S2WB2004 Study Group. Clin Therap 22:970–980, 1:CAS:528:DC%2BD3cXmsFSqtLw%3D
Klassen A, Elkind A, Asgharnejad M, Webster C, Laurenza A (1997) Naratriptan is effective and well tolerated in the acute treatment of migraine. Results of a double-blind, placebo-controlled, parallel-group study. Naratriptan S2WA3001 Study Group. Headache 37:640–645, 9439085, 1:STN:280:DyaK1c7gt1SksA%3D%3D
Kubitzek F, Ziegler G, Gold ML, Liu JMH, Ionescu E (2003) Low-dose diclofenac potassium in the treatment of episodic tension-type headache. Eur J Pain 7:155–162, 12600797, 1:CAS:528:DC%2BD3sXhsFGgtLo%3D
Lewis DW, Kellstein D, Dahl G, Burke B, Frank LM, Toor S, Northam RS, White LW, Lawson L (2002) Children’s ibuprofen suspension for the acute treatment of pediatric migraine. Headache 42:780–786, 12390641
Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A (2004) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 63:2240–2244, 15623680, 1:STN:280:DC%2BD2cnkslWjsw%3D%3D
Lipton RB, Goldstein J, Baggish JS, Yataco AR, Sorrentino JV, Quiring JN (2005) Aspirin is efficacious for the treatment of acute migraine. Headache 45:283–292, 15836564
MacGregor EA, Dowson A, Davies PT (2002) Mouth-dispersible aspirin in the treatment of migraine: a placebo-controlled study. Headache 42:249–255, 12010380
Massiou H, Jamin C, Hinzelin G, Bidaut-Mazel C (2005) The French Naramig Collaborative Study Group. Efficacy of oral Naratriptan in the treatment of menstrually related migraine. Eur J Neurol 12:774–781, 16190915, 1:STN:280:DC%2BD2MrhvVGhtA%3D%3D
Mathew NT, Asgharnejad M, Peykamian M, Laurenza A, Naratriptan is effective, well tolerated in the acute treatment of migraine (1997) Results of a double-blind, placebo-controlled, crossover study. The Naratriptan S2WA3003 Study Group. Neurology 49:1485–1490, 9409334, 1:CAS:528:DyaK1cXitVChuw%3D%3D
Migliardi JR, Armellino JJ, Friedman M, Gillings DB, Beaver WT (1994) Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 56:576–586, 7955822, 1:STN:280:DyaK2M%2FktlymtA%3D%3D
Misra UK, Jose M, Kalita J (2004) Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial. Postgrad Med J 80:720–723, 15579612, 1:CAS:528:DC%2BD2MXktlGqsA%3D%3D
Philipp M (1977) Therapy of migraine. Clinical experience with Migraeflux, a new migraine drug. Fortschr Med 95:107–110, 832830, 1:STN:280:DyaE2s%2Fpt1KitQ%3D%3D
Pothmann R, Danesch U (2005) Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Headache 45:196–203, 15836592
Saper J, Dahlöf C, So Y, Tfelt-Hansen P, Malbecq W, Loeys T, Barraclough E, Klipfel M, Lines C, Visser H, Reines S, Yuen E (2006) Rofecoxib Protocol 162 Study Group. Rofecoxib in the acute treatment of migraine: a randomized controlled clinical trial. Headache 46:264–275, 16492236
Stark S, Spierings EL, McNeal S, Putnam GP, Bolden-Watson CP, O’Quinn S (2000) Naratriptan efficacy in migraineurs who respond poorly to oral sumatriptan. Headache 40:513–520, 10940089, 1:STN:280:DC%2BD3M%2Fls1ahtA%3D%3D
Steiner TJ, Lange R (1998) Ketoprofen (25 mg) in the symptomatic treatment of episodic tension-type headache: double-blind placebo-controlled comparison with acetaminophen (1,000 mg). Cephalalgia 18:38–43, 9601623, 1:STN:280:DyaK1c3mtl2huw%3D%3D
Steiner TJ, Lange R, Voelker M (2003) Aspirin in episodic tension-type headache: placebo-controlled dose-ranging comparison with paracetamol. Cephalalgia 23:59–66, 12534583, 1:STN:280:DC%2BD3s%2FmvFensg%3D%3D
Suthisisang C, Poolsup N, Kittikulsuth W, Pudchakan P, Wiwatpanich P (2007) Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother 41:1782–1791, 17878396, 1:CAS:528:DC%2BD2sXhtlGrtb7P
Wang F, Van Den Eeden SK, Ackerson LM, Salk SE, Reince RH, Elin RJ (2003) Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 43:601–610, 12786918
Zukerman E, Negro MHS, Nothen MR (1990) Comparative study on the efficacy and tolerability of different formulations for Tonopan versus placebo in migraine. Rev Bras Neurol 26:57–60
Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Gøtzsche PC, Lang T, for the CONSORT group (2002) The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 134:663–694
Chan AW, Hrobjartsson A, Haahr MT, Gøtzsche PC, Altman DG (2004) Empirical evidence for selective reporting of outcomes in randomized trials—comparison of protocols to published articles. JAMA 291:2457–2465, 15161896, 1:CAS:528:DC%2BD2cXksVegsL4%3D
García-Berthou E, Alcaraz C (2004) Incongruence between test statistics and P values in medical papers. BMC Med Res Methodol 4:13. doi:10.1186/1471-2288-4-13, 15169550
Gracely E (2008) So, why do I have to correct for multiple comparisons? Concepts and commentary on Turk et al. Pain 139:481–482, 18838224
Turk DC, Dworkin RH, McDermott MP et al (2008) Analyzing multiple endpoints in clinical trials of pain treatments: IMMPACT recommendations. Pain 139:485–493, 18706763
Driscoll P, Lecky F, Crosby M (2000) An introduction to everyday statistics. Part 1. J Accid Emerg Med 17:205–211, 10819386, 1:STN:280:DC%2BD3czpt1Whug%3D%3D
Moher D, Dulberg CS, Wells GA (1994) Statistical power, sample size, and their reporting in randomized controlled trials. JAMA 272:122–124, 8015121, 1:STN:280:DyaK2c3osFemtQ%3D%3D
Halpern SD, Karlawish JHT, Berlin JA (2002) The continuing unethical conduct of underpowered clinical trials. JAMA 288:358–362, 12117401
Gardner MJ, Altman DG (1986) Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J 292:746–750, 1:STN:280:DyaL287mtVOjug%3D%3D
Gehr BT, Weiss C, Porzsolt F (2006) The fading of reported effectiveness. A meta-analysis of randomised controlled trials. BMC Med Res Methodol 6:25. doi:10.1186/1471-2288-6-25
Pray WS (2006) Nonprescription medications and self care. Ethical, scientific, and educational concerns with unproven medications. Am J Pharm Educ 70(141):1–13
Farinelli I, Martelletti P (2007) Aspirin and tension-type headache. J Headache Pain 8:49–55, 17192817, 1:CAS:528:DC%2BD2sXjtVSqt7s%3D
Martelletti P, Farinelli I, Coloprisco G, Patacchioli FR (2007) Role of NSAIDs in acute treatment of headache. Drug Dev Res 68:276–281, 1:CAS:528:DC%2BD1cXhtFaqt7s%3D
Tfelt-Hansen P, Bjarnason NH, Dahlöf C, Derry S, Loder E, Massiou H, Task force on adverse events in migraine trials of the subcommittee on clinical trial of the International Headache Society (2008) Evaluation and registration of adverse events in clinical drug trials in migraine. Cephalalgia 28:683–688, 18498392, 1:STN:280:DC%2BD1cznvVartA%3D%3D
Evers S, May A, Fritsche G, Kropp P, Lampl C, Limmroth V, Malzacher V, Sandor P, Straube A, Diener HC (2008) Akuttherapie und Prophylaxe der Migräne—Leitlinie der Deutschen Migräne-und Kopfschmerzgesellschaft und der Deutschen Gesellschaft für Neurologie. Nervenheilkunde 27:933–949
Diener HC, Lampl C, Reimitz P, Voelker M (2006) Aspirin in the treatment of acute migraine attacks. Expert Rev Neurotherap 6:563–573, 1:CAS:528:DC%2BD28XkvFKhtL4%3D
Pageler L, Diener HC, Pfaffenrath V, Peil H, Aicher B (2009) Clinical relevance of efficacy endpoints in OTC trials. Headache 49:646–654, 19472440
Bergmann JF (2003) Self-medication: from European regulatory directives to therapeutic strategy. Fundam Clin Pharmacol 17:275–280, 12803567, 1:CAS:528:DC%2BD3sXltFamurY%3D
Grossman M, Schmidramsl H (2000) An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther 38:430–435
Packman B, Packman E, Doyle G, Cooper S, Ashraf E, Koronkiewicz K, Jayawardena S (2000) Solubilized ibuprofen: evaluation of onset, relief, and safety of a novel formulation in the treatment of episodic tension-type headache. Headache 40:561–567, 10940094, 1:STN:280:DC%2BD3M%2Fls1agsw%3D%3D
Hofmann R (2008) More to be said on “Triptans vs other drugs for acute migraine. Are there differences in efficacy?”. Headache 49:312–313, 18783444
Glasser SP, Salas M, Delzell E (2007) Importance and challenges of studying marketed drugs: what is a phase IV study? Common clinical research designs, registries, and self-reporting systems. J Clin Pharmacol 47:1074–1086, 17766697
Moore N, Van Ganse E, Le Parc JM, Wall R, Schneid H, Farhan M, Verirere F, Pelen F (1999) The PAIN study: paracetamol, aspirin and ibuprofen new tolerability study. Clin Drug Invest 18:89–98, 1:CAS:528:DyaK1MXlvVansrs%3D
Andrade SE, Martinez C, Walker AM (1998) Comparative safety evaluation of non-narcotic analgesics. J Clin Epidemiol 51:1357–1365, 10086830, 1:STN:280:DyaK1M7osVKgtg%3D%3D
Feleppa M, Apice G, D’Alessio A, Fucci S, Bigal ME (2008) Tolerability of acute migraine medications: influence of methods of assessment and relationship with headache attributes. Cephalalgia 28:1012–1016, 18727650, 1:STN:280:DC%2BD1cnjt1agsQ%3D%3D
McQuay H, Moore A (1998) An evidence-based resource for pain relief. Oxford University Press, Oxford
West RR (2000) Evidence based medicine overviews, bulletins, guidelines, and the new consensus. Postgrad Med J 76:383–389, 10878193, 1:STN:280:DC%2BD3cvit1Cmug%3D%3D
Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G (1991) Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 31:298–301, 1860787, 1:STN:280:DyaK3MzhslKmtw%3D%3D
Peikert A, Willimzig C, Kohne-Volland R (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 16:257–263, 8792038, 1:STN:280:DyaK28zosVWnsw%3D%3D
Pfaffenrath V, Wessely P, Meyer C, Isler H, Evers S, Grotemeyer KH, Taneri Z, Soyka D, Göbel H, Fischer M (1996) Magnesium in the prophylaxis of migraine. A double-blind, placebo-controlled study. Cephalalgia 16:436–440, 8902254, 1:STN:280:DyaK2s%2Flsl2htg%3D%3D
Hershey AD, Powers SW, Vockell AL, Lecates SL, Ellinor PL, Segers A, Burdine D, Manning P, Kabbouche MA (2007) Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache 47:73–80, 17355497
Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD (2002) Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia 22:137–141, 11972582, 1:STN:280:DC%2BD383lsVyisA%3D%3D
Sandor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J (2005) Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 64:713–715, 15728298, 1:CAS:528:DC%2BD2MXpsFyqtw%3D%3D
Maizels M, Blumenfeld A, Burchette R (2004) A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache 44:885–890, 15447697
Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhäupl KM, Arnold G (2004) High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol 11:475–477, 15257686, 1:STN:280:DC%2BD2czlsFWhuw%3D%3D
Schoenen J, Lenaerts M, Bastings E (1994) High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study. Cephalalgia 14:328–329, 7828189, 1:STN:280:DyaK2M7ivFWjsg%3D%3D
Schoenen J, Jacquy J, Lenaerts M (1998) Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 50:466–470, 9484373, 1:CAS:528:DyaK1cXhsl2jtbo%3D
Magis D, Ambrosini A, Sandor P, Jacquy J, Laloux P, Schoenen J (2007) A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache 47:52–57, 17355494
Pradalier A, Bakouche P, Baudesson G, Delage A, Cornaille-Lafage G, Launay JM, Biason P (2001) Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. Cephalalgia 21:818–822, 11737007, 1:STN:280:DC%2BD3MnpsVCitQ%3D%3D
Peres MFP, Zukerman E, da Cunha Tanuri F, Moreira FR, Cipolla-Neto J (2004) Melatonin, 3 mg, is effective for migraine prevention. Neurology 63:757, 15326268, 1:STN:280:DC%2BD2cvhvF2msA%3D%3D
Peres MF (2005) Melatonin, the pineal gland and their implications for headache disorders. Cephalalgia 25:403–411, 15910564, 1:STN:280:DC%2BD2M3mvVGisw%3D%3D
Peres MF, Masruha MR, Zukerman E, Moreira-Filho CA, Cavalheiro EA (2006) Potential therapeutic use of melatonin in migraine and other headache disorders. Exp Op Investig Drugs 15:367–375, 1:CAS:528:DC%2BD28XivVOmsb8%3D
Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B (2006) The fixed combination of acetylsalicylic acid, paracetamol, and caffeine (reply). Cephalalgia 26:1087–1090
Kellstein DE, Lipton RB, Geetha R, Koronkiewicz K, Evans FT, Stewart WF, Wilkes K, Furey SA, Subramanian T, Cooper SA (2000) Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study. Cephalalgia 20:233–243, 10999673, 1:STN:280:DC%2BD3cvkslWjsw%3D%3D
Lipton RB, Baggish S, Stewart WF, Codispoti JR, Fu M (2000) Efficacy and safety of acetaminophen in the treatment of migraine—results of a randomized, double-blind, placebo-controlled, population-based study. Arch Intern Med 160:3486–3492, 11112243, 1:CAS:528:DC%2BD3MXitFSqsw%3D%3D
Scher A, Lipton RN, Bigal M (2010) Response to ‘Comments on results of Scher et al. pertaining to nonprescription caffeine-containing combination analgesics’. Cephalalgia 30:1535–1536, 21108517