MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

Blood - Tập 131 - Trang 2846-2855 - 2018
Hannah Major-Monfried1, Anne S. Renteria1, Attaphol Pawarode2, Pavan Reddy2, Francis Ayuk3, Ernst Holler4, Yvonne A. Efebera5, William J. Hogan6, Matthias Wölfl7, Muna Qayed8, Elizabeth O. Hexner9, Kitsada Wudhikarn10, Rainer Ordemann11, Rachel Young1, Jay Shah1, Matthew J. Hartwell1, Mohammed S. Chaudhry1, Mina Aziz1, Aaron Etra1, Gregory A. Yanik2
1Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY;
2Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI
3Department of Stem Cell Transplantation, University Medical Center, Hamburg-Eppendorf, Germany
4Blood and Marrow Transplantation Program, University of Regensburg, Regensburg, Germany
5Blood and Marrow Transplantation Program, Ohio State University, Columbus, OH
6Blood and Marrow Transplantation Program, Mayo Clinic, Rochester, MN
7Pediatric Blood and Marrow Transplantation Program, Children's Hospital, University of Würzburg, Würzburg, Germany
8Pediatric Blood and Marrow Transplantation Program, Aflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, GA
9Blood and Marrow Transplantation Program, University of Pennsylvania, Philadelphia, PA
10Blood and Marrow Transplantation Program, Chulalongkorn University, Bangkok, Thailand
11Medical Department 1, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Tóm tắt

Key Points

Biomarker scores generated after 1 week of steroid treatment of GVHD are prognostic. Biomarkers reflect prognosis better than early clinical response to GVHD treatment.


Tài liệu tham khảo

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