Glycosphingolipids in microdomain formation and their spatial organization

FEBS Letters - Tập 584 - Trang 1634-1641 - 2010
Garima Gupta1, Avadhesha Surolia1,2
1Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India
2National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India

Tóm tắt

Plasma membranes regulate the influx and efflux of molecules across themselves and are also responsible for primary signal transduction between cells or within the same cell. Presence of lateral heterogeneity and the ability of reorganization are essential requirements for effective functioning of biomembranes. Lipid rafts are small, heterogeneous, dynamic domains enriched in glycosphingolipids, sphingomyelin and cholesterol, and profoundly influence membrane organization. Glycosphingolipids are inclined towards formation of liquid‐ordered phases in membranes, both with and without cholesterol; they are therefore prime players in domain formation. Here, we discuss the role of glycosphingolipids in microdomain formation and their spatial organization within these rafts.


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FEBS Letters

Tập 584

1634-1641

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