Eg5 steps it up!

Springer Science and Business Media LLC - Tập 1 - Trang 1-8 - 2006
Megan T Valentine1, Polly M Fordyce2, Steven M Block1,3
1Department of Biological Sciences, Stanford University, Stanford, USA
2Department of Physics, Stanford University, Stanford, USA
3Department of Applied Physics, Stanford University, Stanford, USA

Tóm tắt

Understanding how molecular motors generate force and move microtubules in mitosis is essential to understanding the physical mechanism of cell division. Recent measurements have shown that one mitotic kinesin superfamily member, Eg5, is mechanically processive and capable of crosslinking and sliding microtubules in vitro. In this review, we highlight recent work that explores how Eg5 functions under load, with an emphasis on the nanomechanical properties of single enzymes.

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Springer Science and Business Media LLC

Tập 1

1-8

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