Life-and-Death Decisions Influenced by Retinoids

Current Topics in Developmental Biology - Tập 35 - Trang 1-46 - 1997
Melissa B. Rogers1
1Departments of Biology, Pharmacology and Institute for Biomolecular Science University of South Florida Tampa, Florida 33620–5150

Tài liệu tham khảo

Abbott, 1988, Retinoic acid alters EGF receptor expression during palatogenesis, Development, 102, 853, 10.1242/dev.102.4.853 Achkar, 1996, 4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors, Proc. Natl. Acad. Sci. U.S.A., 93, 4879, 10.1073/pnas.93.10.4879 Alexandrow, 1995, Transforming growth factor beta and cell cycle regulation, Cancer Res., 55, 1452 Amos, 1990, Retinoid-sensitive cells and cell lines, Meth. Enzymol., 190, 217, 10.1016/0076-6879(90)90026-W Andreasson, 1995, Induction of beta-A activin expression by synaptic activity and during neocortical development, Neuroscience, 69, 781, 10.1016/0306-4522(95)00245-E Ang, 1996, Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression, J. Biol. Chem., 271, 9526, 10.1074/jbc.271.16.9526 Apfel, 1992, A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects, Proc. Natl. Acad. Sci. U.S.A., 89, 7129, 10.1073/pnas.89.15.7129 Argiles, 1989, Retinoic acid affects the cell cycle and increases total protein content in epithelial cells, Kidney Int., 36, 954, 10.1038/ki.1989.287 Armstrong, 1994, General and reproductive toxicology of retinoids, 545 Ballock, 1994, Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta, J. Cell Physiol., 159, 340, 10.1002/jcp.1041590217 Banavali, 1993, The serial study of c-myc expression in bone marrow biopsy specimens during treatment for acute myelogenous leukaemia, Eur. J. Cancer, 29, 1162, 10.1016/S0959-8049(05)80308-9 Bandara, 1991, Adenovirus Ela prevents the retinoblastoma gene product from complexing with a cellular transcription factor, Nature, 351, 494, 10.1038/351494a0 Barettino, 1993, Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR, EMBO J., 12, 1343, 10.1002/j.1460-2075.1993.tb05779.x Bävik, 1996, Developmental abnormalities in cultured mouse embryos deprived of retinoic acid by inhibition of yolk-sac retinol binding protein synthesis, Proc. Natl. Acad. Sci. U.S.A., 93, 3110, 10.1073/pnas.93.7.3110 Beato, 1995, Steroid hormone receptors: Many actors in search of a plot, Cell, 83, 851, 10.1016/0092-8674(95)90201-5 Benedetti, 1996, Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase, Blood, 87, 1939, 10.1182/blood.V87.5.1939.1939 Bérard, 1996, Lung tumors in mice expressing an antisense RARb2 transgene, FASEB J., 10, 1091, 10.1096/fasebj.10.9.8801172 Bernards, 1989, Structure and expression of the murine reti-noblastoma gene and characterization of its encoded protein, Proc. Natl. Acad. Sci. U.S.A., 86, 6474, 10.1073/pnas.86.17.6474 Bissonnette, 1995, 9-Cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation, Mol. Cell. Biol., 15, 5576, 10.1128/MCB.15.10.5576 Blumberg, 1996, Novel retinoic acid receptor ligands in Xenopus embryos, Proc. Natl. Acad. Sci. U.S.A., 93, 4873, 10.1073/pnas.93.10.4873 Bocco, 1993, Rb may act as a transcriptional co-activator in undifferentiated F9 cells, Oncogene, 8, 2977 Boudreau, 1996, Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle, Proc. Natl. Acad. Sci. U.S.A., 93, 3509, 10.1073/pnas.93.8.3509 Boylan, 1995, Targeted disruption of retinoic acid receptor a (RARa) and RARg results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism, Mol. Cell. Biol, 15, 843, 10.1128/MCB.15.2.843 Brooks, 1996, Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor– and retinoid X receptor-selective retinoic acid analogs, Blood, 87, 227 Brunner, 1995, Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas, Nature, 373, 441, 10.1038/373441a0 Buck, 1991, Differences in the action and metabolism between retinol and retinoic acid in B lymphocytes, J. Cell Biol., 115, 851, 10.1083/jcb.115.3.851 Burger, 1994, Lineage-specific regulation of cell cycle gene expression in differentiating myeloid cells, J. Cell Sci., 107, 2047, 10.1242/jcs.107.7.2047 Carpenter, 1990, The epidermal growth factor family, 69 Chambon, 1996, A decade of molecular biology of retinoic acid receptors, FASEB J., 10, 940, 10.1096/fasebj.10.9.8801176 Chang, 1995, The PML gene encodes a phosophoprotein associated with the nuclear matrix, Blood, 85, 3646, 10.1182/blood.V85.12.3646.bloodjournal85123646 Chen, 1993, The erbA oncogene represses the actions of both retinoid X and retinoid A receptors but does so by distinct mechanisms, Mol. Cell Biol., 13, 5970, 10.1128/MCB.13.10.5970 Chen, 1995, RAR-specific agonist/antagonists which dissociate transactivation and API transrepression inhibit anchorage-independent cell proliferation, EMBO J., 14, 1187, 10.1002/j.1460-2075.1995.tb07102.x Chen, 1994, Prevention of spinal neural tube defects in the curly tail mouse mutant by a specific effect of retinoic acid, Dev. Dynamics, 199, 93, 10.1002/aja.1001990203 Chen, 1995, Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma, Development, 121, 681, 10.1242/dev.121.3.681 Choi, 1990, TCP-beta and retinoic acid: Regulators of growth and modifiers of differentiation in human epidermal cells, Cell Regul., 1, 791, 10.1091/mbc.1.11.791 Chomienne, 1996, Retinoid differentiation therapy in promyelo-cytic leukemia, FASEB J., 10, 1025, 10.1096/fasebj.10.9.8801163 Clarke, 1991, Direct transcriptional regulation of the progesterone receptor by retinoic acid diminishes progestin responsiveness in the breast cancer cell line T-47D, J. Biol. Chem., 266, 18969, 10.1016/S0021-9258(18)55158-9 Clifford, 1996, RXRa-null F9 embryonal carcinoma cells are resistant to the differentiation, anti-proliferative and apoptotic effects of retinoids, EMBO J., 15, 4142, 10.1002/j.1460-2075.1996.tb00789.x Colbert, 1995, Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord, Dev. Dynamics, 204, 1, 10.1002/aja.1002040102 Coucouvanis, 1995, Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo, Cell, 83, 279, 10.1016/0092-8674(95)90169-8 Creech Kraft, 1995, Xenopus laevis: A model system for the study of embryonic retinoid metabolism II. Embryonic metabolism of all-trans-3,4-didehydroretinol to all-trans-3,4-didehydroretinoic acid, Drug Metab. Dispos., 23, 83 Cui, 1996, Regulation of T-cell death genes: Selective inhibition of FasL- but not Fas-mediated function, Cell. Immunol., 167, 276, 10.1006/cimm.1996.0036 Cunningham, 1994, From gastrulation to neurulation: Transition in retinoic acid sensitivity identifies distinct stages of neural patterning in the rat, Dev. Dynamics, 200, 227, 10.1002/aja.1002000305 Damm, 1993, Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants, Proc. Natl. Acad. Sci. U.S.A., 90, 2989, 10.1073/pnas.90.7.2989 Davies, 1992, Retinoid-regulated expression of transglutaminases: Links to the biochemistry of programmed cell death, 249 Dawson, 1994, The synthetic chemistry of retinoids, 5 DeGregori, 1995, Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes, Mol. Cell Biol., 15, 4215, 10.1128/MCB.15.8.4215 Delia, 1992, Bcl-2 proto-oncogene expression in normal and neoplastic human my-eloid cells, Blood, 79, 1291, 10.1182/blood.V79.5.1291.1291 Desbois, 1991, A novel mechanism of action for v-Erb-A: Abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors, Cell, 67, 731, 10.1016/0092-8674(91)90068-A Dhein, 1995, Autocrine T-cell suicide mediated by APO-1 (Fas/CD95), Nature, 373, 438, 10.1038/373438a0 Dollé, 1989, Differential expression of genes encoding α, β, and γ retinoic acid receptors and CRABP in the developing limbs of the mouse, Nature, 342, 702, 10.1038/342702a0 Dollé, 1990, Retinoic acid receptors and cellular retinoid binding proteins I. A systematic study of their differential pattern of transcription during mouse organogenesis, Development, 110, 1133, 10.1242/dev.110.4.1133 Dony, 1985, Post-transcriptional control of myc and p53 expression during differentiation of the embryonal carcinoma cell line F9, Nature, 317, 636, 10.1038/317636a0 Duester, 1991, Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: Implications for regulation of retinoic acid synthesis, Mol Cell Biol., 11, 1638, 10.1128/MCB.11.3.1638 Dupin, 1995, Retinoic acid promotes the differentiation of adrenergic cells and melanocytes in quail neural crest cultures, Dev. Biol., 168, 529, 10.1006/dbio.1995.1100 Dyck, 1994, A novel macro-molecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein, Cell, 76, 333, 10.1016/0092-8674(94)90340-9 Epstein, 1991, Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3, Cell, 67, 767, 10.1016/0092-8674(91)90071-6 Evan, 1993, The role of c-myc in cell growth, Curr. Opin. Genet. Dev., 3, 44, 10.1016/S0959-437X(05)80339-9 Evan, 1992, Induction of apoptosis in fibroblasts by c-myc protein, Cell, 63, 119, 10.1016/0092-8674(92)90123-T Evan, 1996, Integrated control of cell proliferation and apoptosis by oncogenes, 109 Fanjul, 1994, A new class of retinoids with selective inhibition of AP-1 inhibits proliferation, Nature, 372, 107, 10.1038/372107a0 Farrow, 1996, New members of the Bcl-2 family and their protein partners, Curr. Opin. Genet. Dev., 6, 45, 10.1016/S0959-437X(96)90009-X Feldman, 1995, Requirement of FGF-4 for postimplantation mouse development, Science, 267, 246, 10.1126/science.7809630 Ferrari, 1992, Abundance of the primary transcript and its processed product of growth related genes in normal and leukemic cells during proliferation and differentiation, Cancer Res., 52, 11 Field, 1996, E2F-1 functions in mice to promote apoptosis and suppress proliferation, Cell, 85, 549, 10.1016/S0092-8674(00)81255-6 Fisher, 1996, Molecular mechanisms of retinoid actions in skin, FASEB J., 10, 1002, 10.1096/fasebj.10.9.8801161 Fisher, 1996, Molecular basis of sun-induced premature skin aging and retinoid antagonism, Nature, 379, 335, 10.1038/379335a0 Forman, 1995, Unique response pathways are established by allosteric interactions among nuclear hormone receptors, Cell, 81, 541, 10.1016/0092-8674(95)90075-6 Formelli, 1996, Bioactivities of N-(4-hydroxyphenyl) retinamide and retinoyl b-glucuronide, FASEB J., 10, 1014, 10.1096/fasebj.10.9.8801162 Francis, 1994, Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb, Development, 120, 209, 10.1242/dev.120.1.209 Gaetano, 1991, Retinoic acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation, Cell Growth Differ., 2, 487 Galaktionov, 1996, Cdc25 cell-cycle phosphatase as a target of c-myc, Nature, 382, 511, 10.1038/382511a0 Gale, 1996, Late effects of retinoic acid on neural crest and aspects of rhombomere identity, Development, 122, 783, 10.1242/dev.122.3.783 Gamow, 1970, The cell life cycle during early embryogenesis of the mouse, Exp. Cell Res., 59, 117, 10.1016/0014-4827(70)90630-0 Gañan, 1996, Role of TGFbs and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod, Development, 122, 2349, 10.1242/dev.122.8.2349 Gentile, 1992, Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: Effects on cellular morphology and adhesion, J. Cell Biol., 119, 463, 10.1083/jcb.119.2.463 Gianni, 1996, AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells, Blood, 87, 1520, 10.1182/blood.V87.4.1520.bloodjournal8741520 Click, 1989, Retinoic acid induces transforming growth factor-beta2 in cultured keratinocytes and mouse epidermis, Cell Reg., 1, 87, 10.1091/mbc.1.1.87 Glozak, 1996, Specific induction of apoptosis in P19 embryonal carcinoma cells by retinoic acid and BMP2 or BMP4, Dev. Biol., 458, 10.1006/dbio.1996.0275 Goodyer, 1995, Repression of the retinoic acid receptor-alpha gene by the Wilms' tumor suppressor gene product, wtl, Oncogene, 10, 1125 Graham, 1994, The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest, Nature, 372, 684, 10.1038/372684a0 Griswold, 1989, Function of vitamin A in normal and synchronized semeniferous tubules, Ann. N.Y. Acad. Sci., 564, 154, 10.1111/j.1749-6632.1989.tb25895.x Grunt, 1992, Comparative analysis of the effects of dimethyl sulfoxide and retinoic acid on the antigenic pattern of human ovarian adenocarcinoma cells, J. Cell Sci., 103, 501, 10.1242/jcs.103.2.501 Gucev, 1996, Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells, Cancer Res., 56, 1545 Gudas, 1994, Cellular biology and biochemistry of the retinoids, 443 HaasKogan, 1995, Inhibition of apoptosis by the retinoblastoma gene product, EMBO J., 14, 461, 10.1002/j.1460-2075.1995.tb07022.x Han, 1996, Highly specific cytochrome P450-like enzymes for all-transretinoic acid in T47D human breast cancer cells, J. Clinical Endocrin. Metab., 81, 2069 Harvey, 1992, Insulin-like growth factor-1 stimulates growth of mouse preimplantation embryos in vitro, Molec. Reproduc. Dev., 31, 195, 10.1002/mrd.1080310306 Hashimoto, 1992, Follistatin is a developmentally regulated cytokine in neural differentiation, J. Biol. Chem., 267, 7203, 10.1016/S0021-9258(18)42503-3 Henion, 1994, Retinoic acid selectively promotes the survival and proliferation of neurogenic precursors in cultured neural crest cell populations, Dev. Biol., 16, 243, 10.1006/dbio.1994.1024 Hermann, 1993, V-erbA requires auxiliary proteins for dominant negative activity, Oncogene, 8, 55 Heyman, 1992, 9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor, Cell, 68, 397, 10.1016/0092-8674(92)90479-V Hill, 1995, Transcriptional regulation by extracellular signals: Mechanisms and specificity, Cell, 80, 199, 10.1016/0092-8674(95)90403-4 Hofmann, 1994, Retinoids in development, 387 Hogan, 1996, Bone morphogenetic proteins: multifunctional regulators of vertebrate development, Genes Dev., 10, 1580, 10.1101/gad.10.13.1580 Horn, 1996, RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells, FASEB J, 10, 1071, 10.1096/fasebj.10.9.8801169 Hu, 1990, Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor a, α, β, and γ mRNAs in F9 teratocarcinoma cells, Mol. Cell. Biol., 10, 391, 10.1128/MCB.10.1.391 Huang, 1988, Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia, Blood, 72, 567, 10.1182/blood.V72.2.567.567 Informatics, 1996 Ishida, 1995, A direct role of transcription factor E2F in c-myc gene expression during granulocytic and macrophage-like differentiation of HL60 cells, Cell Growth Differ., 6, 229 Ito, 1995, Role of retinoic acid in mouse neural crest cell development in vitro, Dev. Dynamics, 204, 211, 10.1002/aja.1002040212 Jiang, 1994, Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53, Oncogene, 9, 3397 Ju, 1995, Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation, Nature, 373, 444, 10.1038/373444a0 Kalemkerian, 1994, All-trans- retinoic acid alters myc gene expression and inhibits in vitro progression in small cell lung cancer, Cell Growth Differ., 5, 55 Kamei, 1996, A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors, Cell, 85, 402, 10.1016/S0092-8674(00)81118-6 Kapron-Bras, 1985, Reduction in the frequency of neural tube defects in splotch mice by retinoic acid, Teratology, 32, 87, 10.1002/tera.1420320112 Kapron-Bras, 1988, Interaction between the splotch mutation and retinoic acid in mouse neural tube defects in vitro, Teratology, 38, 165, 10.1002/tera.1420380209 Kastner, 1995, Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life?, Cell, 83, 859, 10.1016/0092-8674(95)90202-3 Kim, 1995, Retinoid refractoriness occurs during lung carcinogenesis despite functional retinoid receptors, Cancer Res., 55, 5603 Kochhar, 1977, “Chemical surgery” as an approach to study morphogenetic events in embryonic mouse limb, Dev. Biol., 61, 388, 10.1016/0012-1606(77)90310-4 Koken, 1994, The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion, EMBO J., 13, 1073, 10.1002/j.1460-2075.1994.tb06356.x Kranenburg, 1995, Differentiation of P19 EC ceils leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile, Oncogene, 10, 87 Kreidberg, 1993, WT-1 is required for early kidney development, Cell, 74, 679, 10.1016/0092-8674(93)90515-R Kroemer, 1995, The biochemistry of programmed cell death, FASEB J., 9, 1277, 10.1096/fasebj.9.13.7557017 Krupitza, 1995, Retinoic acid induced death of ovarian carcinoma cells correlates with c-myc stimulation, Int. J. Cancer, 61, 649, 10.1002/ijc.2910610511 La Thangue, 1987, An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells, Cell, 49, 507, 10.1016/0092-8674(87)90453-3 Lammer, 1985, Retinoic Acid Embryopathy, N. Engl. J. Med., 313, 837, 10.1056/NEJM198510033131401 Lampron, 1995, Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal, Development, 121, 539, 10.1242/dev.121.2.539 Larsson, 1994, Expression of mad, mxil, max and c-myc during induced differentiation of hematopoietic cells: Opposite regulation of mad and c-myc, Oncogene, 9, 1247 Leblanc, 1995, 9-Cis retinoic acid signaling: changing partners causes some excitement, Genes Dev., 9, 1811, 10.1101/gad.9.15.1811 Lee, 1995, Unimpaired thymic and peripheral T cell death lacking the nuclear receptor NGF1-B (Nur77), Science, 269, 532, 10.1126/science.7624775 Lee, 1995, Cellular aging and transformation suppression: A role for retinoic acid receptor beta 2, Exp. Cell Res., 218, 296, 10.1006/excr.1995.1158 Lee, 1995, Retinoic acid stage dependently alters the migration pattern and identity of hindbrain neural crest cells, Development, 121, 825, 10.1242/dev.121.3.825 Leonard, 1995, Anteriorization of CRABP-I expression by retinoic acid in the developing mouse central nervous system and its relationship to leratogenesis, Dev. Biol., 168, 514, 10.1006/dbio.1995.1099 Li, 1996, Inhibition of tumor promoter induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element, Cancer Res., 56, 483 Licht, 1995, Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11; 17), Blood, 85, 1083, 10.1182/blood.V85.4.1083.bloodjournal8541083 Licht, 1996, Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-a chimera generated in t(11:17)-associated acute promyelocytic leukemia, Oncogene, 12, 323 Liu, 1994, Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77, Nature, 367, 281, 10.1038/367281a0 Lockshin, 1996, The biology of cell death and its relationship to aging, 167 Lohnes, 1994, Function of the retinoic acid receptors (RARs) during development (I) Craniofacial and skeletal abnormalities in RAR double mutants, Development, 120, 2723, 10.1242/dev.120.10.2723 Lotan, 1996, Retinoids in cancer prevention, FASEB J., 10, 1031, 10.1096/fasebj.10.9.8801164 Lotan, 1995, Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation of isotretinoin, N. Engl. J. Med., 332, 1405, 10.1056/NEJM199505253322103 Lowe, 1992, Regulation of insulin-like growth factor I production in ra C6 glioma cells: Possible role as an autocrine/paracrine growth factor, Endocrinology, 130, 2683, 10.1210/endo.130.5.1572288 Lund, 1996, Two distinct phases of apoptosis in mammary gland involution: Proteinase-independent and -dependent pathways, Development, 122, 181, 10.1242/dev.122.1.181 Lyons, 1989, Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor β gene super family, Proc. Natl. Acad. Sci. USA, 86, 4554, 10.1073/pnas.86.12.4554 Mahmood, 1992, Interactions between retinoids and TGF betas in mouse morphogenesis, Development, 115, 67, 10.1242/dev.115.1.67 Martin, 1980, Teratocarcinomas and mammalian embryogenesis, Science, 209, 768, 10.1126/science.6250214 Martin, 1995, Insulin-like growth factor-binding protein-3 production by MCF-7 breast cancer cells: Stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol, Endocrinology, 136, 1219, 10.1210/endo.136.3.7532580 Meikrantz, 1996, Suppression of apoptosis by dominant-negative mutants of cyclin-dependent protein kinases, J. Biol. Chem., 271, 10205, 10.1074/jbc.271.17.10205 Mendelsohn, 1991, Developmental analysis of the retinoic acid-inducible RAR-b2 promoter in transgenic animals, Development, 113, 723, 10.1242/dev.113.3.723 Milligan, 1996, Programmed cell death during development of animals, 181 Moon, 1994, Retinoids and cancer in experimental animals, 573 Mordan, 1989, Inhibition by retinoids of platelet growth factor-dependent stimulation of DNA synthesis and celll division in density-arrested C3H 10T1/2 fibroblasts, Cancer Res., 49, 906 Morgan, 1995, Principles of CDK regulation, Nature, 374, 131, 10.1038/374131a0 Morriss-Kay, 1992, Morphogenesis-related changes in extracellular matrix induced by retinoic acid, 165 Morriss-Kay, 1996, Embryonic development and pattern formation, FASEB J., 10, 961, 10.1096/fasebj.10.9.8801178 Müller, 1984, Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes, Nature, 311, 438, 10.1038/311438a0 Murray, 1993 Nagpal, 1995, Separation of transactivation and AP1 antagonism functions of retinoic acid receptor alpha, J. Biol. Chem., 270, 923, 10.1074/jbc.270.2.923 Nagy, 1995, Activation of retinoid X receptors induces apoptosis in HL-60 cell lines, Mol. Cell Biol., 15, 3540, 10.1128/MCB.15.7.3540 Nagy, 1996, Identification and characterization of a versatile retinoid response element (retinoic acid receptor response element-retinoid X receptor response element) in the mouse tissue transglutaminase gene promoter, J. Biol. Chem., 271, 4355, 10.1074/jbc.271.8.4355 Nagy, 1996, Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human myeloid leukemia (HL-60) cells, Leukemia Res., 499, 10.1016/0145-2126(95)00118-2 Napoli, 1996, Retinoic acid biosynthesis and metabolism, FASEB J., 10, 993, 10.1096/fasebj.10.9.8801182 Naumovski, 1994, Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells, Blood, 83, 2261, 10.1182/blood.V83.8.2261.2261 Okazawa, 1996, Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells, J. Cell Biol., 132, 955, 10.1083/jcb.132.5.955 Oridate, 1996, Implication of retinoic acid receptor gamma in squamous differentiation and response to retinoic acid in head and neck SqCC/Y1 squamous carcinoma cells, Oncogene, 12, 2019 Pan, 1995, Suppression of collagenase gene expression by all-trans and 9-cis retinoic acid is ligand dependent and requires both RARs and RXRs, J. Cell. Biochem., 57, 575, 10.1002/jcb.240570402 Pandey, 1995, Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse, J. Cell. Biochem., 58, 135, 10.1002/jcb.240580203 Pardee, 1989, G1 events and regulation of cell proliferation, Science, 246, 602, 10.1126/science.2683075 Park, 1994, Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes, Blood, 84, 440, 10.1182/blood.V84.2.440.440 Perez, 1993, PMLRAR homo-dimers: Distinct DNA binding properties and heteromeric interactions with RXR, EMBO J., 12, 3171, 10.1002/j.1460-2075.1993.tb05986.x Perlmann, 1995, A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1, Genes Dev., 9, 769, 10.1101/gad.9.7.769 Peters, 1996, The D-cyclins, their kinases and their inhibitors, 77 Peterson, 1996, “Natural” cancer prevention trial halted, Science, 271, 441, 10.1126/science.271.5248.441b Piacentini, 1994, Tissue transglutaminase in cells undergoing apoptosis, 143 Pijnappel, 1993, The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification, Nature, 366, 340, 10.1038/366340a0 Privalsky, 1992, Retinoid and thyroid hormone receptors: Ligand-regulated transcription factors as proto-oncogenes, Sem. Cell Biol., 3, 66, 10.1016/S1043-4682(10)80019-4 Qin, 1994, Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis, Proc. Natl. Acad. Sci., USA, 91, 10918, 10.1073/pnas.91.23.10918 Reichel, 1992, Regulation of E2F/cyclin A-containing complex upon retinoic acid-induced differentiation of teratocarcinoma cells, Gene Expr., 2, 259 Reichel, 1987, Developmental control of a promoter-specific factor that is also regulated by the E1 A gene product, Cell, 48, 501, 10.1016/0092-8674(87)90200-5 Roach, 1995, Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis, J. Cell Biol., 131, 483, 10.1083/jcb.131.2.483 Roberts, 1994, Cyclins, cdks, and cyclin kinase inhibitors, CSH Symp. Quant. Biol., LIX, 31, 10.1101/SQB.1994.059.01.006 Roberts, 1990, A novel epithelial cell from neonatal rat lung: Isolation and differentiated phenotype, Am. J. Physiol., 259, L415 Robertson, 1987 Robertson, 1992, Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand binding domain that confers dominant negative activity, Blood, 80, 1885, 10.1182/blood.V80.8.1885.1885 Rogers, 1996, Receptor-selective retinoids implicate RAR alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells, Cell Growth Diff., 7, 115 Rogers, 1992, Bone morphogenetic proteins-2 and 4 are involved in the retinoic acid-induced differentiation of embryonal carcinoma cells, Molec. Biol. Cell, 3, 189, 10.1091/mbc.3.2.189 Rosenstraus, 1982, Cell-cycle characteristics of undifferentiated and differentiating embryonal carcinoma cells, Dev. Biol., 89, 516, 10.1016/0012-1606(82)90340-2 Rossant, 1991, Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis, Genes Dev., 5, 1333, 10.1101/gad.5.8.1333 Roy, 1995, Mol. Cell Biol., 15, 6481, 10.1128/MCB.15.12.6481 Ruberte, 1991, Retinoic acid receptors and cellular retinoid binding proteins II. Their differential pattern of transcription during early morphogenesis in mouse embryos, Development, 111, 45, 10.1242/dev.111.1.45 Ruberte, 1992, Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis, Development, 115, 973, 10.1242/dev.115.4.973 Saunders, 1993, Inhibition of c-myc in breast and ovarian carcinoma cells by 1,25- dihydroxyvitamin D3, retinoic acid and dexamethasone, Anticancer Drugs, 4, 201, 10.1097/00001813-199304000-00012 Saunders, 1995, Alcohol inhibits neurite extension and increases N-myc and c-myc proteins, Alcohol, 12, 475, 10.1016/0741-8329(95)00034-O Savatier, 1994, Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts, Oncogene, 9, 809 Savatier, 1996, Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cy-clin-dependent kinase inhibitors in mouse embryonic stem cells, Oncogene, 12, 309 Schimmang, 1994, The mouse mutant Polydactyly Nagoya (Pdn) defines a novel allele of the zinc finger gene Gli3, Mamm. Genome, 5, 384, 10.1007/BF00356560 Schofield, 1991, Differentiation associated modulation of K-FGF expression in a human teratocarcinoma cell line and in primary germ cell tumors, FEBS Lett., 280, 8, 10.1016/0014-5793(91)80192-6 Schoorlemmer, 1991, Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells, Mech. Dev., 36, 75, 10.1016/0925-4773(91)90074-G Schubert, 1990, Activin is a nerve cell survival molecule, Nature, 344, 868, 10.1038/344868a0 Schüle, 1991, Retinoic acid is a negative regulator of AP-1 responsive genes, Proc. Natl. Acad. Sci. USA, 88, 6092, 10.1073/pnas.88.14.6092 Schulze-Osthoff, 1994, The Fas/APO-1 receptor and its deadly ligand, Trends Cell Biol., 4, 421, 10.1016/0962-8924(94)90102-3 Schwaller, 1995, Posttranscriptional stabilization underlies p53-independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells, J. Clin. Invest., 95, 973, 10.1172/JCI117806 Schwartz, 1995, Cell Death, 459 Scita, 1996, Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells Blocks of this response by ras transformation, J. Biol. Chem., 271, 6502, 10.1074/jbc.271.11.6502 Scott, 1994, Enhanced expression of limb malformations and axial skeleton alterations in legless mutants by transplacental exposure to retinoic acid, Dev. Biol., 164, 277, 10.1006/dbio.1994.1198 Seewaldt, 1995, Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells, Cell Growth Differ., 6, 1077 Shan, 1994, Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis, Mol. Cell. Biol., 14, 8166, 10.1128/MCB.14.12.8166 Sheikh, 1993, Retinoid modulation of c-myc and max gene expression in human breast carcinoma, Anticancer Res., 13, 1387 Sheikh, 1995, N-4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoic receptor-independent pathways in human breast carcinoma, Carcinogenexis, 16, 2477, 10.1093/carcin/16.10.2477 Sherr, 1994, G1 phase progressions: Cycling on cue, Cell, 79, 551, 10.1016/0092-8674(94)90540-1 Sherr, 1995, Inhibitors of mammalian G1 cyclin-dependent kinases, Genes Dev., 9275, 1149, 10.1101/gad.9.10.1149 Shi, 1994, Premature p34cdc2 activation required for apoptosis, Science, 263, 1143, 10.1126/science.8108732 Slack, 1993, Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells, Oncogene, 8, 1585 Slack, 1995, Adenovirus 5 E1A-induced differentiation of P19 embryonal carcinoma cells requires binding to p300, Oncogene, 10, 19 Slack, 1995, Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins, J. Cell Biol., 129, 779, 10.1083/jcb.129.3.779 Smith-Thomas, 1987, Effects of isotretinoin on the behavior of neural crest cells in vitro, Dev. Biol., 123, 276, 10.1016/0012-1606(87)90449-0 Somay, 1992, Relationship of myc protein expression to the phenotype and to the growth potential of HOC-7 ovarian cancer cells, Br. J. Cancer, 66, 93, 10.1038/bjc.1992.223 Sporn, 1994, Introduction, 1 Stemple, 1992, Isolation of a stem cell for neurons and glia from the mammalian neural crest, Cell, 71, 973, 10.1016/0092-8674(92)90393-Q Suda, 1993, Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family, Cell, 75, 1169, 10.1016/0092-8674(93)90326-L Sulik, 1988, Teratogens and craniofacial malformations: Relationships to cell death, Development, 103, 213, 10.1242/dev.103.Supplement.213 Swisshelm, 1994, Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells, Cell Growth Differ., 5, 133 Sympson, 1994, Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression, J. Cell Biol., 125, 681, 10.1083/jcb.125.3.681 Tabin, 1995, The initiation of the limb bud: Growth factors, Hox genes, and retinoids, Cell, 80, 671, 10.1016/0092-8674(95)90343-7 Takatsuka, 1996, Retinoic acid metabolism and inhibition of cell proliferation: An unexpected liaison, Cancer Res, 56, 675 Talmage, 1994, Retinoic acid suppresses polyoma virus transformation by inhibiting transcription of the c-fos proto-oncogene, Oncogene, 9, 3557 Tamagawa, 1995, Effects of all-trans-retinoic acid on limb development in the genetic polydactyly mouse, J. Toxicol. Sci., 20, 383, 10.2131/jts.20.4_383 Taneja, 1996, Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies fr RARb2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts, Proc. Natl. Acad. Sci. USA, 93, 6197, 10.1073/pnas.93.12.6197 Tautz, 1992, Redundancies, development and the flow of information, Bioessays, 14, 263, 10.1002/bies.950140410 Thaller, 1990, Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud, Nature, 345, 815, 10.1038/345815a0 Thomas, 1996, Apoptosis and Cell Cycle Control Thorogood, 1982, Effects of vitamin A on the behavior of migratory neural crest cells in vitro, J. Cell Sci., 57, 331, 10.1242/jcs.57.1.331 Tickle, 1982, Local application of retinoic acid to the limb bond mimics the action of the polarizing region, Nature, 296, 564, 10.1038/296564a0 Trauth, 1989, Monoclonal antibody-mediated tumor regression by induction of apo-ptosis, Science, 245, 301, 10.1126/science.2787530 Tsai, 1992, A mutated retinoic acid receptor-a exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line, Genes Dev., 6, 2258, 10.1101/gad.6.12a.2258 van den Eijnden-van Raaij, 1992, Differential expression of inhibin subunits and follistatin, but not of activin receptor type II, during early murine embryonic development, Dev. Biol., 154, 356, 10.1016/0012-1606(92)90074-Q van der Leede, 1995, Retinoic acid receptor alpha I isoform is induced by estradiol and confers retinoic acid sensitivity in human breast cancer cells, Mol. Cell Endocrinol., 109, 77, 10.1016/0303-7207(95)03487-R Velcich, 1989, Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells, Oncogene Res., 5, 31 Verma, 1979, Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion, Cancer Res., 39, 419 Vogan, 1993, The splotch-delayed (Spd) mouse mutant carries a point mutation within the paired box of the Pax-3 gene, Genomics, 17, 364, 10.1006/geno.1993.1333 Weinberg, 1995, The retinoblastoma protein and cell cycle control, Cell, 81, 323, 10.1016/0092-8674(95)90385-2 Weis, 1994, Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells, Cell, 76, 345, 10.1016/0092-8674(94)90341-7 Whyte, 1996, The retinoblastoma family of proteins, 77 Wilcken, 1996, Differential effects of retinoids and antiestrogenes on cell cycle progression and cell cycle regulatory genes in human breast cancer cells, Cell Growth Diff., 7, 65 Wiley, 1995, Epidermal growth factor receptor function in early mammalian development, BioEssays, 17, 839, 10.1002/bies.950171005 Wolf, 1996, A History of Vitamin A and Retinoids, FASEB J., 10, 1102, 10.1096/fasebj.10.9.8801174 Wood, 1994, Exposure to retinoic acid before or after the onset of somitogenesis reveals separate effects on rhombomeric segmentation and 3′ HoxB gene expression domains, Development, 120, 2279, 10.1242/dev.120.8.2279 Woronicz, 1994, Requirement for the orphan steroid receptor Nur77 in apoptosis of T cell hybridomas, Nature, 367, 277, 10.1038/367277a0 Wu, 1994, p53 and E2F-1 expression leads to 5-phase entry and p53-mediated apoptosis, Proc. Natl. Acad. Sci. USA, 91, 3602, 10.1073/pnas.91.9.3602 Yamaguchi-Iwai, 1990, Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes, Proc. Natl. Acad. Sci. USA, 87, 8670, 10.1073/pnas.87.21.8670 Yamasaki, 1996, Tumor induction and tissue atrophy in mice lacking E2F-1, Cell, 85, 537, 10.1016/S0092-8674(00)81254-4 Yang, 1992, Characterization of the mucin differentiation in human lung adenocarcinoma cell lines, Am. J. Respir. Cell Mol. Blol., 7, 161, 10.1165/ajrcmb/7.2.161 Yang, 1993, 9-Cis-retinoic acid inhibits activation-driven T-cell apoptosis: Implications for retinoid X receptor involvement in thymocyte development, Proc. Natl. Acad. Sci. USA, 90, 6170, 10.1073/pnas.90.13.6170 Yang, 1995, Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells, Proc. Natl. Acad. Sci. USA, 92, 3051, 10.1073/pnas.92.7.3051 Yang, 1995, Efficient inhibition of activation-induced Fas ligand up-regulation and T cell apoptosis by retinoids requires occupancy of both retinoid X receptors and retinoic acid receptors, J. Biol. Chem., 270, 18672, 10.1074/jbc.270.31.18672 Yen, 1992, Coupled down-regulation of the RB retinoblastoma and c-myc genes antecedes cell differentiation: Possible role of RB as a “status quo” gene, Eur. J. Cell Biol., 57, 210 Zakeri, 1993, Delayed internucleosomal DNA fragmentation in programmed cell death, FASEB J., 7, 470, 10.1096/fasebj.7.5.8462789 Zauli, 1995, All-trans retinoic acid shows multiple effects on the survival, proliferation and differentiation of human fetal CD34+ haemopoietic progenitor cells, Br. J. Haematol., 90, 274, 10.1111/j.1365-2141.1995.tb05147.x Zelent, 1994, Translocation of the RAR alpha locus to the PML or PLZF gene in acute promyelocytic leukaemia, Br. J. Haematol., 86, 451, 10.1111/j.1365-2141.1994.tb04773.x Zhang, 1992, Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid, Nature, 358, 587, 10.1038/358587a0 Zhang, 1995, Evidence for the involvement of retinoic acid receptor RAR alpha-dependent signaling pathway in the induction of tissue transglutaminase and apoptosis by retinoids, J. Biol. Chem., 270, 6022, 10.1074/jbc.270.11.6022 Zhang, 1995, p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation, Cancer Res., 55, 668 Zou, 1996, Requirement for BMP signaling in interdigital apoptosis and scale formation, Science, 272, 738, 10.1126/science.272.5262.738