Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review

International Journal of Cosmetic Science - Tập 40 Số 2 - Trang 103-116 - 2018
Vivian Sáez1, Ingrid Dantas Luciano de Souza1, Cláudia R. E. Mansur1
1Institute of Macromolecules (IMA/UFRJ) Federal University of Rio de Janeiro Av. Horácio Macedo, 2030 Rio de Janeiro RJ 21941598 Brazil

Tóm tắt

AbstractThe antioxidative and photoprotective properties of vitamin E have caused it to be included as an active agent in various pharmaceutical and cosmetic products. However, its lipophilicity, chemical instability and poor skin penetration have limited the effectiveness of these formulations. For that reason, many attempts to include it in different drug delivery systems have been made. In recent decades, lipid nanoparticles have received special attention due to their advantages of compatibility with the skin, ability to enhance penetration of drugs in the stratum corneum, protection of the encapsulated substance against degradation induced by the external medium and control of drug release. This work reviews the current status of the encapsulation of vitamin E in lipid nanoparticles. We describe the most important methods for obtaining and characterizing lipid nanoparticles containing vitamin E (LNP‐VE), various techniques for the evaluation of vitamin E's properties after encapsulation, the mainin vitroandin vivostudies of the potential effectiveness or toxicity ofLNP‐VE, the formulations and stability studies of this delivery system, the commercial products based onLNP‐VEand the regulatory aspects related to lipid nanoparticles. Finally, we discuss the most relevant advantages of encapsulating vitamin E in such particles and critical aspects that still demand attention to enhance the potential of solid lipid nanoparticles to deliver vitamin E.

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Tài liệu tham khảo

Ravisankar P., 2015, The Comprehensive Review on Fat Soluble Vitamins, IOSR J. Pharm., 5, 12

10.1016/j.jconrel.2010.01.037

10.2174/1573412910666140630170055

10.1111/j.1524-4725.2005.31724

10.4103/2229-5178.185494

Montenegro L., 2014, Nanocarriers for skin delivery of cosmetic antioxidants, J. Pharm. Pharmacogn. Res., 2, 73, 10.56499/jppres14.033_2.4.73

10.14356/kona.2013015

10.4028/www.scientific.net/AMR.236-238.2207

10.1089/jop.1997.13.537

10.1016/j.carbpol.2010.07.002

10.1002/adem.201080047

10.3233/JAD-2005-7405

10.1016/j.foodchem.2015.05.005

10.1016/j.ijpharm.2014.02.034

10.1016/j.ejpb.2008.10.003

10.2478/acph-2014-0021

10.1016/j.ejpb.2017.04.008

10.1111/ics.12119

10.2174/157016311796799062

Shah M., 2017, Solid lipid nanoparticles (SLN) for oral drug delivery: An overview, J. Nanomed. Nanosci., 2017, 1

Ekambaram P., 2012, Solid lipid nanoparticles: a review, Sci. Revs. Chem. Commun., 2, 80

10.1016/j.ijpharm.2008.10.003

10.1016/j.addr.2007.04.012

10.4103/0975-7406.99016

Shylaja P., 2016, Preparation and characterization of alpha tocopherol loaded solid lipid nanoparticles by hot homogenization method, IJPPR Human., 7, 437

Nair H., 2015, Optimization of formulation parameters for preparation of docetaxel loaded nanostructured lipid carriers, Int. J. Pharm. Sci. Res., 6, 2846

10.15171/apb.2015.043

10.1016/j.ijpharm.2016.08.049

10.4028/www.scientific.net/KEM.675-676.77

10.1371/journal.pone.0171662

10.1080/02652048.2017.1284276

10.1016/j.crci.2013.12.007

10.2174/157016312799304552

10.3390/nano7060122

10.1016/j.nano.2015.09.004

10.3109/1061186X.2012.716845

10.1517/17425247.2012.673278

10.1016/j.ejpb.2005.11.004

10.1016/j.addr.2012.09.021

10.1166/jnn.2012.5690

Gupta D.R., 2016, Solubility enhancement by solid lipid nanoparticle, IJPPR Human., 7, 351

10.1016/j.ifset.2013.03.002

Patel K., 2015, Nanostructured lipid carrier—a novel drug delivery, J. Pharm. Sci. Bioscientific. Res., 5, 585

10.1080/026520499288690

10.1046/j.1467-2494.2001.00087.x

10.1016/j.ijbiomac.2005.05.003

10.1016/j.indcrop.2013.04.054

Oehlke K., 2011, Proceedings of the 11th International Congress on Engineering and Food, 121

10.1016/j.colsurfb.2009.03.032

Ma Q. Wang Y. Lin X. Luo D.andGu N.Preparation characterization and photoprotection of tocopherol loaded nanostructured lipid carriers. In:International Conference on Complex Medical Engineering ‐ CME 2007 pp.203–208. IEEE Beijing China (2007).

10.11113/mjfas.v13n3.596

Kim B.K., 2016, Nanostructured‐lipid carriers for the encapsulation of vitamin E, J Food Process Technol., 7, 63

Negretto C.M.U., 2013, Análise de transportador lipídico nanoestruturado contendo vitamina e através da espectrofotometria UV/VIS, Disciplinarum Scientia| Naturais e Tecnológicas., 14, 89

Soni K., 2016, Lipid nanoparticles: future of oral drug delivery and their current trends and regulatory issues, Int. J. Curr. Pharm. Rev. Res., 7, 1

Nair R., 2011, Recent advances in solid lipid nanoparticle based drug delivery systems, J. Biomed. Sci. Res., 3, 368

Dubey A., 2012, Nano Structured lipid carriers: A Novel Topical drug delivery system, Int. J. PharmTech. Res., 4, 705

Surender V., 2016, Solid lipid nanoparticles: a comprehensive review, J. Chem. Pharm. Res., 8, 102

10.1166/jbn.2007.049

10.1016/j.colsurfa.2013.04.016

Kaliamurthi S., 2016, Insight on solid lipid nanoparticles: characterization and application in diabetes mellitus, J. Crit. Rev., 3, 11

10.1111/j.1468-2494.2008.00433.x

Yadav N., 2013, Solid lipid nanoparticles ‐ A review, Int. J. App. Pharm., 5, 8

10.1517/17425247.2012.666967

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Thông tin xuất bản

International Journal of Cosmetic Science

Tập 40 Số 2

103-116

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