Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

Creagh EM, O'Neill LA: TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006, 27:352–357.

Bianchi ME: DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 2007, 81:1–5.

Piccinini AM, Midwood KS: DAMPening inflammation by modulating TLR signalling. Mediators Inflamm 2010.

Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, Hood LE, Aderem A: The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A 2005, 102:9577–9582.

Bowie A, O'Neill LA: The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J Leukoc Biol 2000, 67:508–514.

Frei R, Steinle J, Birchler T, Loeliger S, Roduit C, Steinhoff D, Seibl R, Buchner K, Seger R, Reith W, Lauener RP: MHC class II molecules enhance Toll-like receptor mediated innate immune responses. PLoS One 2010, 5:e8808.

Ransohoff RM, Brown MA: Innate immunity in the central nervous system. J Clin Invest 2012, 122:1164–1171.

Downes CE, Crack PJ: Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? Br J Pharmacol 2010, 160:1872–1888.

Simi A, Lerouet D, Pinteaux E, Brough D: Mechanisms of regulation for interleukin-1beta in neurodegenerative disease. Neuropharmacology 2007, 52:1563–1569.

Lehnardt S, Lachance C, Patrizi S, Lefebvre S, Follett PL, Jensen FE, Rosenberg PA, Volpe JJ, Vartanian T: The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 2002, 22:2478–2486.

Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA, Volpe JJ, Vartanian T: Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A 2003, 100:8514–8519.

Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R, Schwartz M: Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 2007, 9:1081–1088.

Acosta C, Davies A: Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons. J Neurosci Res 2008, 86:1077–1086.

Tu Z, Portillo JA, Howell S, Bu H, Subauste CS, Al-Ubaidi MR, Pearlman E, Lin F: Photoreceptor cells constitutively express functional TLR4. J Neuroimmunol 2011, 230:183–187.

Okun E, Griffioen KJ, Mattson MP: Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci 2011, 34:269–281.

Pinteaux E, Parker LC, Rothwell NJ, Luheshi GN: Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J Neurochem 2002, 83:754–763.

Nguyen L, Rothwell NJ, Pinteaux E, Boutin H: Contribution of interleukin-1 receptor accessory protein B to interleukin-1 actions in neuronal cells. Neurosignals 2011, 19:222–230.

Saini MG, Pinteaux E, Lee B, Bix GJ: Oxygen-glucose deprivation and interleukin-1alpha trigger the release of perlecan LG3 by cells of neurovascular unit. J Neurochem 2011, 119:760–771.

MacRedmond RE, Greene CM, Dorscheid DR, McElvaney NG, O'Neill SJ: Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Respir Res 2007, 8:84.

Lehnardt S: Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia 2010, 58:253–263.

Yoo KY, Yoo DY, Hwang IK, Park JH, Lee CH, Choi JH, Kwon SH, Her S, Lee YL, Won MH: Time-course alterations of Toll-like receptor 4 and NF-kappaB p65, and their co-expression in the gerbil hippocampal CA1 region after transient cerebral ischemia. Neurochem Res 2011, 36:2417–2426.

Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, Rossetti C, Molteni M, Casalgrandi M, Manfredi AA, Bianchi ME, Vezzani A: Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 2010, 16:413–419.

Johnson EA, Dao TL, Guignet MA, Geddes CE, Koemeter-Cox AI, Kan RK: Increased expression of the chemokines CXCL1 and MIP-1alpha by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats. J Neuroinflammation 2011, 8:41.

Chow FC, Marra CM, Cho TA: Cerebrovascular disease in central nervous system infections. Semin Neurol 2011, 31:286–306.

Qiu J, Nishimura M, Wang Y, Sims JR, Qiu S, Savitz SI, Salomone S, Moskowitz MA: Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab 2008, 28:927–938.

Zhang Z, Zhang ZY, Wu Y, Schluesener HJ: Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury. Neuroimmunomodulation 2012, 19:10–19.