Signal Transduction by the TGF-β Superfamily

American Association for the Advancement of Science (AAAS) - Tập 296 Số 5573 - Trang 1646-1647 - 2002
Liliana Attisano1, Jeffrey L. Wrana2,3
1Department of Anatomy and Cell Biology
2Department of Medical Genetics and Microbiology, University of Toronto, Toronto M5S 1A8, Canada
3Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada. E-mail: [email protected] (L.A.) and [email protected] (J.L.W.)

Tóm tắt

Transforming growth factor–β (TGF-β) superfamily members regulate a plethora of developmental processes, and disruption of their activity has been implicated in a variety of human diseases ranging from cancer to chondrodysplasias and pulmonary hypertension. Intense investigations have revealed that SMAD proteins constitute the basic components of the core intracellular signaling cascade and that SMADs function by carrying signals from the cell surface directly to the nucleus. Recent insights have revealed how SMAD proteins themselves are regulated and how appropriate subcellular localization of SMADs and TGF-β transmembrane receptors is controlled. Current research efforts investigating the contribution of SMAD-independent pathways promise to reveal advances to enhance our understanding of the signaling cascade.

Từ khóa


Tài liệu tham khảo

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10.1016/S1097-2765(01)00382-3

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 296 Số 5573

1646-1647

Thông tin tác giả