Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials

Whiting, 2011, IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030, Diabetes Res Clin Pract, 94, 311, 10.1016/j.diabres.2011.10.029 Guariguata, 2012, By the numbers: new estimates from the IDF Diabetes Atlas Update for 2012, Diabetes Res Clin Pract, 98, 524, 10.1016/j.diabres.2012.11.006 Chen, 2012, The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives, Nat Rev Endocrinol, 8, 228, 10.1038/nrendo.2011.183 Zimmet, 2001, Global and societal implications of the diabetes epidemic, Nature, 414, 782, 10.1038/414782a Makrilakis, 2010, Implementation and effectiveness of the first community lifestyle intervention programme to prevent Type 2 diabetes in Greece. The DE-PLAN study, Diabet Med, 27, 459, 10.1111/j.1464-5491.2010.02918.x Hamer, 2007, Intake of fruit, vegetables, and antioxidants and risk of type 2 diabetes: systematic review and meta-analysis, J Hypertens, 25, 2361, 10.1097/HJH.0b013e3282efc214 Colditz, 1992, Diet and risk of clinical diabetes in women, Am J Clin Nutr, 55, 1018, 10.1093/ajcn/55.5.1018 Meyer, 2000, Carbohydrates, dietary fiber, and incident type 2 diabetes in older women, Am J Clin Nutr, 71, 921, 10.1093/ajcn/71.4.921 Liu, 2004, A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women, Diabetes Care, 27, 2993, 10.2337/diacare.27.12.2993 Montonen, 2005, Food consumption and the incidence of type II diabetes mellitus, Eur J Clin Nutr, 59, 441, 10.1038/sj.ejcn.1602094 Muraki, 2013, Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies, BMJ, 347, f5001, 10.1136/bmj.f5001 Baur, 2006, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, 444, 337, 10.1038/nature05354 Lagouge, 2006, Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha, Cell, 127, 1109, 10.1016/j.cell.2006.11.013 Sun, 2007, SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B, Cell Metab, 6, 307, 10.1016/j.cmet.2007.08.014 Um, 2010, AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol, Diabetes, 59, 554, 10.2337/db09-0482 Barger, 2008, A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice, PLoS ONE, 3, e2264, 10.1371/journal.pone.0002264 Su, 2006, Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats, Am J Physiol Endocrinol Metab, 290, E1339, 10.1152/ajpendo.00487.2005 Szkudelski, 2011, Anti-diabetic effects of resveratrol, Ann N Y Acad Sci, 1215, 34, 10.1111/j.1749-6632.2010.05844.x Moher, 1998, Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses, Lancet, 352, 609, 10.1016/S0140-6736(98)01085-X Higgins, 2003, Measuring inconsistency in meta-analyses, BMJ, 327, 557, 10.1136/bmj.327.7414.557 Follmann, 1992, Variance imputation for overviews of clinical trials with continuous response, J Clin Epidemiol, 45, 769, 10.1016/0895-4356(92)90054-Q Dash, 2013, High-dose resveratrol treatment for 2 weeks inhibits intestinal and hepatic lipoprotein production in overweight/obese men, Arterioscler Thromb Vasc Biol, 33, 2895, 10.1161/ATVBAHA.113.302342 Poulsen, 2013, High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition, Diabetes, 62, 1186, 10.2337/db12-0975 Movahed, 2013, Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients, Evid Based Complement Alternat Med, 2013, 851267, 10.1155/2013/851267 Bhatt, 2012, Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus, Nutr Res, 32, 537, 10.1016/j.nutres.2012.06.003 Yoshino, 2012, Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance, Cell Metab, 16, 658, 10.1016/j.cmet.2012.09.015 Tome-Carneiro, 2012, One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease, Am J Cardiol, 110, 356, 10.1016/j.amjcard.2012.03.030 Tomé-Carneiro, 2012, Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial, Mol Nutr Food Res, 56, 810, 10.1002/mnfr.201100673 Magyar, 2012, Cardioprotection by resveratrol: a human clinical trial in patients with stable coronary artery disease, Clin Hemorheol Microcirc, 50, 179, 10.3233/CH-2011-1424 Brasnyó, 2011, Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients, Br J Nutr, 106, 383, 10.1017/S0007114511000316 Fujitaka, 2011, Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment, Nutr Res, 31, 842, 10.1016/j.nutres.2011.09.028 Timmers, 2011, Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans, Cell Metab, 14, 612, 10.1016/j.cmet.2011.10.002 Palsamy, 2010, Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats, J Cell Physiol, 224, 423, 10.1002/jcp.22138 Palsamy, 2008, Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats, Biomed Pharmacother, 62, 598, 10.1016/j.biopha.2008.06.037 Jiang, 2008, Sirtuins: novel targets for metabolic disease in drug development, Biochem Biophys Res Commun, 373, 341, 10.1016/j.bbrc.2008.06.048 Penumathsa, 2008, Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium, J Cell Mol Med, 12, 2350, 10.1111/j.1582-4934.2008.00251.x Chi, 2007, Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats, Life Sci, 80, 1713, 10.1016/j.lfs.2007.02.002 Ramadori, 2009, Central administration of resveratrol improves diet-induced diabetes, Endocrinology, 150, 5326, 10.1210/en.2009-0528 Szkudelski, 2006, Resveratrol inhibits insulin secretion from rat pancreatic islets, Eur J Pharmacol, 552, 176, 10.1016/j.ejphar.2006.09.046 Szkudelski, 2007, Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances, Am J Physiol Endocrinol Metab, 293, E901, 10.1152/ajpendo.00564.2006 Szkudelski, 2008, The insulin-suppressive effect of resveratrol—an in vitro and in vivo phenomenon, Life Sci, 82, 430, 10.1016/j.lfs.2007.12.008 Lee, 2009, Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway, Diabetes, 58, 344, 10.2337/db07-1795 Thirunavukkarasu, 2007, Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of nitric oxide, thioredoxin, and heme oxygenase, Free Radic Biol Med, 43, 720, 10.1016/j.freeradbiomed.2007.05.004 Kennedy, 2009, Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol, J Lipid Res, 50, 225, 10.1194/jlr.M800258-JLR200 Jeon, 2012, Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet, Diabetes, 61, 1444, 10.2337/db11-1498 Juan, 2002, The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful, J Nutr, 132, 257, 10.1093/jn/132.2.257 Punthakee, 2013, Role of the laboratory in diabetes diagnosis and screening—the 2013 CDA CPGs, Clin Biochem, 46, 707, 10.1016/j.clinbiochem.2013.04.019 2013, Diagnosis and classification of diabetes mellitus, Diabetes Care, 36, S67 Schulz, 2010, CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials, Ann Intern Med, 152, 726, 10.7326/0003-4819-152-11-201006010-00232