Leisure‐time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study

Alzheimer's & Dementia - Tập 15 - Trang 273-281 - 2019
Priya Palta1, A. Richey Sharrett2, Jennifer A. Deal2, Kelly R. Evenson1, Kelley Pettee Gabriel3,4, Aaron R. Folsom5, Alden L. Gross2, B. Gwen Windham6, David Knopman7, Thomas H. Mosley6, Gerardo Heiss1
1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
2Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
3Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Austin, TX, USA
4Department of Women's Health, University of Texas at Austin, Dell Medical School, Austin, TX, USA
5Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
6Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
7Department of Neurology, Mayo Clinic, Rochester, MN, USA

Tóm tắt

AbstractIntroductionWe tested the hypotheses that higher levels of and persistence of midlife leisure‐time physical activity (LTPA) are associated long‐term with lower cognitive decline and less incident dementia.MethodsA total of 10,705 participants (mean age: 60 years) had LTPA (no, low, middle, or high) measured in 1987‐1989 and 1993‐1995. LTPA was assessed in relation to incident dementia and 14‐year change in general cognitive performance.ResultsOver a median follow‐up of 17.4 years, 1063 dementia cases were observed. Compared with no LTPA, high LTPA in midlife was associated with lower incidence of dementia (hazard ratio [95% confidence interval], 0.71 [0.61, 0.86]) and lower declines in general cognitive performance (−0.07 standard deviation difference [−0.12 to −0.04]). These associations were stronger when measured against persistence of midlife LTPA over 6 years.DiscussionLTPA is a readily modifiable factor associated inversely with long‐term dementia incidence and cognitive decline.

Tài liệu tham khảo

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Alzheimer's & Dementia

Tập 15

273-281

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