Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy

Löffler, 2000, A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes., Blood, 95, 2098, 10.1182/blood.V95.6.2098 Bargou, 2008, Tumor regression in cancer patients by very low doses of a T cell-engaging antibody., Science, 321, 974, 10.1126/science.1158545 Topp Topp Topp, 2012, Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL., Blood, 120, 5185, 10.1182/blood-2012-07-441030 Klinger, 2012, Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab., Blood, 119, 6226, 10.1182/blood-2012-01-400515 Tang, 2008, Early diagnostic and prognostic significance of a specific Th1/Th2 cytokine pattern in children with haemophagocytic syndrome., Br J Haematol, 143, 84, 10.1111/j.1365-2141.2008.07298.x Xu Kalos, 2011, T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia., Sci Transl Med, 3, 95ra73, 10.1126/scitranslmed.3002842 Porter, 2011, Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia., N Engl J Med, 365, 725, 10.1056/NEJMoa1103849 Grupp, 2013, Chimeric antigen receptor-modified T cells for acute lymphoid leukemia., N Engl J Med, 368, 1509, 10.1056/NEJMoa1215134 Allen, 2008, Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis., Pediatr Blood Cancer, 50, 1227, 10.1002/pbc.21423 Switala, 2012, Serum ferritin is a cost-effective laboratory marker for hemophagocytic lymphohistiocytosis in the developing world., J Pediatr Hematol Oncol, 34, e89, 10.1097/MPH.0b013e31824227b9 Olin, 2008, Successful use of the anti-CD25 antibody daclizumab in an adult patient with hemophagocytic lymphohistiocytosis., Am J Hematol, 83, 747, 10.1002/ajh.21236 Tamura, 2008, Increased serum monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, and interleukin-8 concentrations in hemophagocytic lymphohistiocytosis., Pediatr Blood Cancer, 51, 662, 10.1002/pbc.21660 Gore Risma, 2012, Hemophagocytic lymphohistiocytosis: updates and evolving concepts., Curr Opin Pediatr, 24, 9, 10.1097/MOP.0b013e32834ec9c1 Zhizhuo, 2012, Screening the PRF1, UNC13D, STX11, SH2D1A, XIAP, and ITK gene mutations in Chinese children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis., Pediatr Blood Cancer, 58, 410, 10.1002/pbc.23216 Zhang, 2011, Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH., Blood, 118, 5794, 10.1182/blood-2011-07-370148 Trizzino, 2008, Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis due to perforin mutations., J Med Genet, 45, 15, 10.1136/jmg.2007.052670