Molecular epidemiology of recent HIV‐1 infections in southern Poland

Journal of Medical Virology - Tập 84 Số 12 - Trang 1857-1868 - 2012
Joanna Smoleń‐Dzirba1, Magdalena Rosińska2, Piotr Kruszyński1, Jolanta Bratosiewicz‐Wąsik1, Janusz Janiec2, Marek Beniowski3, Monika Bociąga‐Jasik4, Elżbieta Jabłonowska5, Bartosz Szetela6, Kholoud Porter7, Tomasz J. Wąsik1
1Department and Institute of Microbiology and Virology, The School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice, Poland
2Department of Epidemiology, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland
3Department of Diagnostics and Therapy for AIDS, Specialistic Hospital in Chorzów, Chorzów, Poland
4Chair of Gastroenterology, Hepatology and Infectious Diseases, Department of Infectious Diseases of the Jagiellonian University, Collegium Medicum, Kraków, Poland
5Medical University of Lodz, Clinic of Infectious Diseases and Hepatology, Łódź, Poland
6Department and Clinic of Infectious Diseases, Wrocław Medical University, Hepatology and Acquired Immune Deficiencies, Wrocław, Poland
7Medical Research Council Clinical Trials Unit, London, UK

Tóm tắt

Abstract

The genetic diversity of human immunodeficiency virus type 1 (HIV‐1) offers an opportunity to track the development of the epidemic across different populations. Viral pol gene fragments from 55 individuals of Polish origin with recent HIV‐1 infection identified in 2008–2010 in four Polish cities were analyzed. Viral sequences were compared with sequences from 100 individuals (reference group) infected before 2004. Viral spread among groups with different HIV transmission categories was compared using a phylogenetic approach. The majority of sequences from individuals with recent infection were subtype B (93%) within which four transmission clusters (18% of samples) were detected. Samples from men infected through sex between men and from persons infected through injecting drugs were broadly separated (P < 0.0001), while samples from individuals infected by heterosexual contacts were dispersed uniformly within phylogenetic tree (P = 0.244) inferred from viral sequences derived from individuals infected recently and the reference group. The percentage of samples from persons infected by heterosexual contacts which clustered with samples from men infected through sex between men was not significantly higher for those with recent infection (47%), compared to the reference group (36%). In conclusion, men infected by sex between men and individuals infected through injecting drugs appear to form separate HIV transmission networks in Poland. The recent spread of HIV‐1 among persons infected with subtype B by heterosexual contacts appears to be linked to both these groups. J. Med. Virol. 84:1857–1868, 2012. © 2012 Wiley Periodicals, Inc.

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Journal of Medical Virology

Tập 84 Số 12

1857-1868

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