Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Nature Medicine - Tập 24 Số 5 - Trang 563-571 - 2018
Joseph A. Fraietta1, Simon F. Lacey1, Elena J. Orlando2, Iulian Pruteanu-Malinici2, Mercy Gohil3, Stefan Lundh3, Alina C. Boesteanu3, Yan Wang3, Roddy S. O’Connor3, Wei‐Ting Hwang4, Edward Pequignot3, David E Ambrose3, Changfeng Zhang3, Nicholas S. Wilcox3, Felipe Bedoya3, Corin L. Dorfmeier3, Chen Fang3, Lifeng Tian3, Harit Parakandi3, Minnal Gupta3, Regina M. Young3, F. Brad Johnson1, Irina Kulikovskaya3, Li Liu3, Jun Xu3, Sadik H. Kassim2, Megan M. Davis3, Bruce L. Levine3, Noelle V. Frey3, Don L. Siegel3, Alexander C. Huang5, E. John Wherry5, Hans Bitter2, Jennifer L. Brogdon2, David L. Porter6, Carl H. June5, J. Joseph Melenhorst5
1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA USA
2Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
3Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA
4Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA
5Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA
6Division of Hematology-Oncology, Department of Internal Medicine, University of Pennsylvania, Philadelphia, PA, USA

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