Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

Violeta Romero1, Justyna Fert‐Bober2, Peter A. Nigrović3,4, Erika Darrah1, Uzma Haque1, David M. Lee4, Jennifer E. Van Eyk2, Antony Rosen5,1, Felipe Andrade1
1Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
2Division of Cardiology, Department of Medicine, Department of Biological Chemistry and the Johns Hopkins Bayview Proteomics Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
3Division of Immunology, Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
4Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
5Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

Tóm tắt

RA-associated hypercitrullination is specifically induced by immune-mediated membrane pore-forming pathways.

Từ khóa


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