Primary structure of rat chromogranin A and distribution of its mRNA

FEBS Letters - Tập 227 - Trang 115-121 - 1988
Anna Iacangelo1, Hiroto Okayama2, Lee E. Eiden1
1Unit on Molecular and Cellular Neurobiology, NIMH, Bethesda, MD 20892, USA
2Laboratory of Cell Biology, NIMH, Bethesda, MD 20892, USA

Tóm tắt

The primary structure of rat chromogranin A has been deduced from a rat adrenal cDNA clone. A comparison of rat and bovine chromogranin A reveals several similar features: clusters of polyglutamic acid, similar amino acid composition, position of seven of 10 pairs of basic amino acids, identical placement of the only two cysteine residues, a highly conserved N‐ and C‐terminus, and a sequence homologous to porcine pancreastatin 1–49 [(1986) Nature 324, 476–478]. Unique features of rat chromogranin A are an eicosaglutamine sequence and two potential N‐linked glycosylation sites. Chromogranin A mRNA is detectable in adrenal medulla, anterior pituitary, cerebral cortex, and hippocampus, as well as tumor cell lines derived from pancreas, pituitary, and adrenal medulla.

Tài liệu tham khảo

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FEBS Letters

Tập 227

115-121

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