Postsurgical adjuvant or metastatic renal cell carcinoma therapy models reveal potent antitumor activity of metronomic oral topotecan with pazopanib

Christopher Jedeszko1, Marta Pàez‐Ribes1, Teresa Di Desidero2, Shan Man1, Christina R. Lee1, Ping Xu1, Georg A. Bjarnason3, Guido Bocci2, Robert S. Kerbel1,4
1Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
2Divisione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Pisa 56126, Italy.
3Sunnybrook Odette Cancer Centre, Toronto, Ontario M4N 3M5, Canada.
4Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 2J7, Canada.

Tóm tắt

The combination of metronomic topotecan and pazopanib has potent antitumor effects in models of primary and metastatic renal cancer.

Từ khóa


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