Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection

Blood - Tập 106 - Trang 3366-3369 - 2005
Galit Alter1, Nickolas Teigen1, Benjamin T. Davis1, Marylyn M. Addo1, Todd J. Suscovich1, Michael T. Waring1, Hendrik Streeck1, Mary N. Johnston1, Kyle D. Staller1, M. Tauheed Zaman1, Xu G. Yu1, Mathias Lichterfeld1, Nesli Basgoz1, Eric S. Rosenberg1, Marcus Altfeld1
1From the Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA.

Tóm tắt

AbstractNatural killer (NK) cells are critical in the first-line defense against viral infections. Chronic HIV-1 infection leads to a perturbation in the NK cell compartment, yet the kinetics of this deregulation and the functional consequences are unclear. Here, we characterized changes in the NK cell compartment longitudinally by multiparameter flow cytometry, starting in acute HIV-1 infection. Acute HIV-1 infection was associated with elevated NK cell numbers, with an expansion of CD3negCD56dimCD16pos NK cells and an early depletion of CD3negCD56brightCD16neg NK cells. Ongoing viral replication resulted in a depletion of CD3negCD56dimCD16pos NK cells with a paralleled increase in functionally anergic CD3negCD56negCD16pos NK cells, accompanied by reduced functional activity, as measured by CD107a expression and cytokine secretion. Taken together, these studies demonstrate a sequential impairment of NK cell function with persistent viral replication resulting from a progressive deregulation of NK cell subsets with distinct functional properties.

Tài liệu tham khảo

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Blood

Tập 106

3366-3369

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