Association of Nuclear Factor‐Erythroid 2‐Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase‐1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients

Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Angélica Saraí Jiménez‐Osorio1, Susana González-Reyes1, Wylly Ramsés García‐Niño1, Hortensia Moreno-Macías2, Martha Eunice Rodríguez-Arellano3, Gilberto Vargas‐Alarcón4, Joaquı́n Zúñiga5, Rodrigo Barquera6, José Pedraza-Chaverrı́1
1Department of Biology, National Autonomous University of Mexico (UNAM), 04510 Mexico City DF, Mexico
2Economy Department, Autonomous Metropolitan University-Iztapalapa, 09340 Mexico City, DF, Mexico
3Research Department, Regional Hospital “Lic. Adolfo López Mateos”, ISSSTE, 01030 Mexico City, DF, Mexico
4Molecular Biology Department, National Institute of Cardiology “Ignacio Chávez”, 14080 Mexico City, DF, Mexico
5Department of Immunology, National Institute of Respiratory Diseases “Ismael Cosío Villegas”, 14080 Mexico City, DF, Mexico
6Molecular Genetics Laboratory, National School of Anthropology and History, 14030 Mexico City, DF, Mexico

Tóm tắt

The nuclear factor‐erythroid 2‐ (NF‐E2‐) related factor 2 (Nrf2) is abated and its ability to reduce oxidative stress is impaired in type 2 diabetes and obesity. Thus, the aim of this study was to explore if polymorphisms in Nrf2 and target genes are associated with diabetes and obesity in Mexican mestizo subjects. The rs1800566 of NAD(P)H:quinone oxidoreductase 1 (NQO1) gene, rs7211 of thioredoxin interacting protein (TXNIP) gene, rs2071749 of heme oxygenase‐1 (HMOX1) gene, and the rs6721961 and the rs2364723 from Nrf2 gene were genotyped in 627 diabetic subjects and 1020 controls. The results showed that the rs7211 polymorphism is a protective factor against obesity in nondiabetic subjects (CC + CT versus TT, OR = 0.40, P = 0.005) and in women (CC versus CT + TT, OR = 0.7, P = 0.016). TT carriers had lower high‐density lipoprotein cholesterol levels and lower body mass index. The rs2071749 was positively associated with obesity (AA versus AG + GG, OR = 1.25, P = 0.026). Finally, the rs6721961 was negatively associated with diabetes in men (CC versus CA + AA, OR = 0.62, P = 0.003). AA carriers showed lower glucose concentrations. No association was found for rs1800566 and rs2364723 polymorphisms. In conclusion, the presence of Nrf2 and related genes polymorphisms are associated with diabetes and obesity in Mexican patients.

Từ khóa


Tài liệu tham khảo

International Diabetes Federation, 2015, Diabetes Atlas

10.2337/dc11-0447

10.1016/j.exger.2015.02.010

10.1046/j.1365-2362.1998.0280s2014.x

10.1016/j.bbagen.2011.03.014

10.1055/s-0028-1088302

10.3390/ijms160716483

10.3390/ijms151120290

10.1074/jbc.m109.093955

10.1155/2013/286524

Shimoyama Y., 2014, Polymorphisms of Nrf2, an antioxidative gene, are associated with blood pressure in Japanese, Nagoya Journal of Medical Science, 76, 113

10.1152/physiolgenomics.00178.2013

10.1016/s0076-6879(04)82008-1

10.1007/s00228-015-1915-y

10.1016/j.cca.2010.02.071

10.1016/j.ymgme.2009.01.012

10.1007/s11010-011-1098-5

10.1371/journal.pone.0123313

10.1097/MD.0000000000001825

10.1089/gtmb.2010.0103

10.4049/jimmunol.164.12.6287

10.1124/mol.112.081133

10.1111/j.1464-5491.2007.02109.x

10.1016/j.atherosclerosis.2011.12.009

10.1093/nar/17.20.8390

10.1371/journal.pone.0074442

10.1016/S0379-0738(00)00422-9

10.1007/s00414-004-0505-9

10.1007/s00414-004-0488-6

10.1002/ajhb.20787

10.2337/db10-1164

10.1155/2013/184598

10.1002/oby.20929

10.1016/j.abb.2014.12.012

10.1016/j.bbrc.2005.12.195

10.4093/kdj.2009.33.1.24

10.1210/jc.2011-0101

10.1186/1471-2350-12-117

10.7150/ijms.8590

Thông tin
Thông tin xuất bản

Oxidative Medicine and Cellular Longevity

Tập 2016 Số 1

Thông tin tác giả