Sensitivity of thermoacidophilic archaebacteria to α‐sarcin

FEBS Letters - Tập 171 - Trang 63-66 - 1984
J.L. Sanz1, R. Amils1
1Centro de Biologia Molecular, CSIC and UAM, Canto Blanco, Madrid 34, Spain

Tóm tắt

The protein synthesis machinery of Sulfolobus solfataricus, a thermoacidophilic archaebacterium, is insensitive to most of the known antibiotics that interfere with elongation. α‐Sarcin, a cytotoxic protein, inhibits protein synthesis on eukaryotic systems by cleaving a specific sequence of the large rRNA. α‐Sarcin is capable of inhibiting protein synthesis on S. solfataricus producing a fragment under conditions similar to those which produce it in yeast ribosomes. This result suggests the presence on S. solfataricus of the sequence necessary for the enzymatic hydrolysis promoted by α‐sarcin.

Tài liệu tham khảo

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FEBS Letters

Tập 171

63-66

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