GVHD prevents NK-cell–dependent leukemia and virus-specific innate immunity

Shlomchik, 2007, Graft-versus-host disease, Nat Rev Immunol, 7, 340, 10.1038/nri2000 Ferrara, 2009, Graft-versus-host disease, Lancet, 373, 1550, 10.1016/S0140-6736(09)60237-3 Huntington, 2007, Developmental pathways that generate natural-killer-cell diversity in mice and humans, Nat Rev Immunol, 7, 703, 10.1038/nri2154 Sun, 2011, NK cell development, homeostasis and function: parallels with CD8+ T cells, Nat Rev Immunol, 11, 645, 10.1038/nri3044 Huntington, 2014, The unconventional expression of IL-15 and its role in NK cell homeostasis, Immunol Cell Biol, 92, 210, 10.1038/icb.2014.1 Huntington, 2007, NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation, J Immunol, 178, 4764, 10.4049/jimmunol.178.8.4764 Hayakawa, 2006, CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity, J Immunol, 176, 1517, 10.4049/jimmunol.176.3.1517 Lanier, 2005, NK cell recognition, Annu Rev Immunol, 23, 225, 10.1146/annurev.immunol.23.021704.115526 Andoniou, 2008, Killers and beyond: NK-cell-mediated control of immune responses, Eur J Immunol, 38, 2938, 10.1002/eji.200838882 Degli-Esposti, 2005, Close encounters of different kinds: dendritic cells and NK cells take centre stage, Nat Rev Immunol, 5, 112, 10.1038/nri1549 Olson, 2010, NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects, Blood, 115, 4293, 10.1182/blood-2009-05-222190 Miller, 2013, Therapeutic applications: natural killer cells in the clinic, Hematology Am Soc Hematol Educ Program, 247 Cooke, 1996, An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin, Blood, 88, 3230, 10.1182/blood.V88.8.3230.bloodjournal8883230 Schuster, 2014, TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity, Immunity, 41, 646, 10.1016/j.immuni.2014.09.013 Henden, 2015, Cytokines in graft-versus-host disease, J Immunol, 194, 4604, 10.4049/jimmunol.1500117 Hill, 1997, Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines, Blood, 90, 3204, 10.1182/blood.V90.8.3204 Kasaian, 2002, IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity, Immunity, 16, 559, 10.1016/S1074-7613(02)00295-9 Brady, 2004, IL-21 induces the functional maturation of murine NK cells, J Immunol, 172, 2048, 10.4049/jimmunol.172.4.2048 Liu, 2006, Autoreactive T cells mediate NK cell degeneration in autoimmune disease, J Immunol, 176, 5247, 10.4049/jimmunol.176.9.5247 Viel, 2016, TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway, Sci Signal, 9, ra19, 10.1126/scisignal.aad1884 Lodolce, 1998, IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation, Immunity, 9, 669, 10.1016/S1074-7613(00)80664-0 Koyama, 2015, Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease, J Exp Med, 212, 1303, 10.1084/jem.20150329 Burkett, 2004, Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis, J Exp Med, 200, 825, 10.1084/jem.20041389 Cooper, 2002, In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells, Blood, 100, 3633, 10.1182/blood-2001-12-0293 Varelias, 2015, Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation, Blood, 125, 2435, 10.1182/blood-2014-07-590232 Robb, 2012, Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation, Blood, 119, 5898, 10.1182/blood-2011-12-396119 Kuballa, 2012, Autophagy and the immune system, Annu Rev Immunol, 30, 611, 10.1146/annurev-immunol-020711-074948 O’Sullivan, 2015, BNIP3- and BNIP3L-mediated mitophagy promotes the generation of natural killer cell memory, Immunity, 43, 331, 10.1016/j.immuni.2015.07.012 Sathe, 2014, Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells, Nat Commun, 5, 4539, 10.1038/ncomms5539 Hercend, 1986, Characterization of natural killer cells with antileukemia activity following allogeneic bone marrow transplantation, Blood, 67, 722, 10.1182/blood.V67.3.722.bloodjournal673722 Eissens, 2010, CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A, Leukemia, 24, 583, 10.1038/leu.2009.269 Zhao, 2011, Conflicting impact of alloreactive NK cells on transplantation outcomes after haploidentical transplantation: do the reconstitution kinetics of natural killer cells create these differences?, Biol Blood Marrow Transplant, 17, 1436, 10.1016/j.bbmt.2011.05.020 Nguyen, 2008, Involvement of mature donor T cells in the NK cell reconstitution after haploidentical hematopoietic stem-cell transplantation, Leukemia, 22, 344, 10.1038/sj.leu.2405041 Cooley, 2005, KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation, Blood, 106, 4370, 10.1182/blood-2005-04-1644 Foley, 2011, NK cell education after allogeneic transplantation: dissociation between recovery of cytokine-producing and cytotoxic functions, Blood, 118, 2784, 10.1182/blood-2011-04-347070 Ullah, 2016, Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation, Front Immunol, 7, 144, 10.3389/fimmu.2016.00144 Abrahamsen, 2005, Immune reconstitution after allogeneic stem cell transplantation: the impact of stem cell source and graft-versus-host disease, Haematologica, 90, 86 Kheav, 2014, Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation, Haematologica, 99, 1860, 10.3324/haematol.2014.108407 Pidala, 2014, Biologic markers of chronic GVHD, Bone Marrow Transplant, 49, 324, 10.1038/bmt.2013.97 Ljungman, 2011, Cytomegalovirus in hematopoietic stem cell transplant recipients, Hematol Oncol Clin North Am, 25, 151, 10.1016/j.hoc.2010.11.011 Ruggeri, 2002, Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants, Science, 295, 2097, 10.1126/science.1068440 Ruggeri, 2007, Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value, Blood, 110, 433, 10.1182/blood-2006-07-038687 Locatelli, 2009, Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference, Clin Immunol, 133, 171, 10.1016/j.clim.2009.04.009 Elmaagacli, 2011, Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients, Blood, 118, 1402, 10.1182/blood-2010-08-304121 Green, 2013, CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia, Blood, 122, 1316, 10.1182/blood-2013-02-487074 Hokland, 1988, Natural killer function following allogeneic bone marrow transplantation. Very early reemergence but strong dependence of cytomegalovirus infection, Transplantation, 45, 1080, 10.1097/00007890-198806000-00016 Cichocki, 2016, The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer, Curr Top Microbiol Immunol, 395, 225 Della Chiesa, 2014, Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C-/- umbilical cord blood, J Immunol, 192, 1471, 10.4049/jimmunol.1302053 Horowitz, 2015, Regulation of adaptive NK cells and CD8 T cells by HLA-C correlates with allogeneic hematopoietic cell transplantation and with cytomegalovirus reactivation, J Immunol, 195, 4524, 10.4049/jimmunol.1401990 Wang, 2016, FoxO1-mediated autophagy is required for NK cell development and innate immunity, Nat Commun, 7, 11023, 10.1038/ncomms11023 Velardi, 2012, Killer-cell immunoglobulin-like receptors reactivity and outcome of stem cell transplant, Curr Opin Hematol, 19, 319, 10.1097/MOH.0b013e32835423c3 Miller, 2007, Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT, Blood, 109, 5058, 10.1182/blood-2007-01-065383 Hsu, 2005, Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes, Blood, 105, 4878, 10.1182/blood-2004-12-4825 Cooley, 2009, Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia, Blood, 113, 726, 10.1182/blood-2008-07-171926 Miller, 2005, Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer, Blood, 105, 3051, 10.1182/blood-2004-07-2974 Gill, 2012, Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells, Blood, 119, 5758, 10.1182/blood-2012-03-415364 Blaser, 2005, Donor-derived IL-15 is critical for acute allogeneic graft-versus-host disease, Blood, 105, 894, 10.1182/blood-2004-05-1687 Roychowdhury, 2005, IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease, Blood, 106, 2433, 10.1182/blood-2005-04-1597 Shah, 2015, Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation, Blood, 125, 784, 10.1182/blood-2014-07-592881